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Coagulation factor viia Side Effects

Not all side effects for coagulation factor viia may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to coagulation factor viia: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by coagulation factor viia. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking coagulation factor viia, check with your doctor or nurse immediately:

More common
  • Bleeding problems
  • fever
  • high blood pressure
  • joint or muscle pain or stiffness
Less common or rare
  • Bloating or swelling of the face, hands, lower legs, or feet
  • bluish color of the hands or feet
  • blurred vision
  • changes in facial color
  • chest pain
  • chills
  • cold sweats
  • confusion
  • continuing thirst
  • cough
  • dizziness
  • excessive sweating
  • faintness
  • fast heartbeat
  • hives, itching, or skin rash
  • large flat blue or purplish patches on the skin
  • lightheadedness when getting up suddenly from a lying or sitting position
  • persistent bleeding or oozing from puncture sites or mucous membranes (bowel, mouth, nose, or urinary bladder)
  • puffiness or swelling of the eyelids or around the eyes
  • shakiness
  • slow or irregular heartbeat (less than 50 beats per minute)
  • slurred speech
  • sneezing
  • sore throat
  • sudden decrease in the amount of urine
  • swelling of the face, fingers, feet, or lower legs
  • troubled breathing, tightness in the chest
  • unusual tiredness or weakness
  • unusual weight gain

Some of the side effects that can occur with coagulation factor viia may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common or rare
  • Burning or stinging at the injection site
  • drowsiness
  • feeling of warmth
  • headache
  • nausea or vomiting
  • pinpoint red or purple spots on the skin
  • redness of the face, neck, arms and occasionally, upper chest

For Healthcare Professionals

Applies to coagulation factor viia: intravenous powder for injection


Hematologic side effects have included hemorrhage, decreased plasma fibrogen, coagulation disorders, increased fibrinolysis, decreased prothrombin, disseminated intravascular coagulation, thrombophlebitis, arterial thrombosis, and deep vein thrombosis.[Ref]


Cardiovascular side effects have included edema, hypertension, hypotension, myocardial infarction, angina pectoris, and bradycardia.[Ref]


General side effects have included pain and fever.[Ref]

Nervous system

Nervous system side effects have included headache, intracranial hemorrhage, cerebral infarction, cerebral ischemia, and subdural hematoma.[Ref]


Hypersensitivity side effects have included isolated cases of hypersensitivity reactions including anaphylactic reactions.[Ref]


Respiratory side effects have included pulmonary embolism and pneumonia.[Ref]


Local side effects have included injection site reaction.[Ref]


Gastrointestinal side effects have included nausea and vomiting.[Ref]


Dermatologic side effects have included rash, pruritus, and purpura.[Ref]


Musculoskeletal side effects have included arthralgia and hemarthrosis.[Ref]


Renal side effects have included abnormal renal function.[Ref]


1. "Product Information. NovoSeven (coagulation factor VIIa)" Novo Nordisk Pharmaceuticals, Princeton, NJ.

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