coagulation factor VIIa

Generic Name: coagulation factor VIIa (injection) (koe AG yoo LAY shun FAK tor)
Brand Name: NovoSeven RT, NovoSeven RTwith MixPro, NovoSeven

What is coagulation factor VIIa?

Coagulation factor VIIa is a man-made protein similar to a natural protein in the body that helps the blood to clot.

Coagulation factor VIIa is used to treat or prevent bleeding in people with hemophilia A or hemophilia B, or factor VII deficiency.

Coagulation factor VIIa may also be used for purposes not listed in this medication guide.

What is the most important information I should know about coagulation factor VIIa?

If possible before you receive coagulation factor VIIa, tell your doctor about all your medical conditions and allergies. Also make sure your doctor knows if you are pregnant or breast-feeding.

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Call your doctor at once if you have sudden numbness or weakness, sudden cough or headache, pain or swelling in one or both legs, chest pain, or problems with vision, speech, or balance.

What should I discuss with my healthcare provider before receiving coagulation factor VIIa?

You should not receive coagulation factor VIIa if you are allergic to it.

If possible before you receive coagulation factor VIIa, tell your doctor if you have:

  • coronary artery disease (hardening of the arteries);

  • a history of stroke or heart attack;

  • a severe injury or infection;

  • liver disease; or

  • if you are allergic to mouse, hamster, or cow proteins.

In an emergency situation it may not be possible to tell your caregivers about your health conditions. Make sure any doctor caring for you afterward knows you have received this medicine.

FDA pregnancy category C. It is not known whether coagulation factor VIIa will harm an unborn baby. Tell your doctor if you are pregnant.

It is not known whether coagulation factor VIIa passes into breast milk or if it could harm a nursing baby. You should not breast-feed while receiving this medicine.

In an emergency situation it may not be possible to tell your caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you have received this medication.

How is coagulation factor VIIa given?

Coagulation factor VIIa is injected into a vein through an IV. A healthcare provider will give you this injection.

You may need frequent medical tests to help your doctor determine how long to treat you with coagulation factor VIIa.

Wear a medical alert tag or carry an ID card stating that you have a bleeding disorder in case of emergency. Any medical care provider who treats you should know that you are using coagulation factor VIIa.

What happens if I miss a dose?

Because you will receive coagulation factor VIIa in a clinical setting, you are not likely to miss a dose.

What happens if I overdose?

Because you will receive coagulation factor VIIa in a clinical setting, you are not likely to miss a dose.

What should I avoid after receiving coagulation factor VIIa?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Coagulation factor VIIa side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • sudden numbness or weakness, especially on one side of the body;

  • sudden severe headache, confusion, problems with vision, speech, or balance;

  • chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;

  • pain, swelling, warmth, or redness in one or both legs;

  • fever;

  • little or no urinating;

  • a feeling that you might pass out; or

  • any bleeding that will not stop.

Common side effects may include:

  • mild headache;

  • joint pain;

  • nausea, vomiting;

  • swelling;

  • mild itching or rash; or

  • pain, redness, swelling, or irritation where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Coagulation factor VIIa dosing information

Usual Adult Dose for Hemophilia A:

Treatment of bleeding episodes in hemophilia A or B with inhibitors:
90 micrograms/kg by intravenous bolus injection every 2 hours until hemostasis is achieved. Post-hemostatic dosing every 3 to 6 hours for severe bleeds.

Prevention of bleeding in surgical interventions or invasive procedures in hemophilia A or B with inhibitors:
90 micrograms/kg by intravenous injection immediately before surgery and every 2 hours during surgery. Post-surgical dosing: For minor procedures, dosing every 2 hours for 48 hours and then every 2 to 6 hours, and for major procedures every 2 hours for the first 5 days and then every 4 hours, until healing has occurred.

Acquired hemophilia - bleeding episodes or surgery:
70 to 90 micrograms/kg by intravenous bolus injection every 2 to 3 hours until hemostasis is achieved.

Usual Adult Dose for Hemophilia B:

Treatment of bleeding episodes in hemophilia A or B with inhibitors:
90 micrograms/kg by intravenous bolus injection every 2 hours until hemostasis is achieved. Post-hemostatic dosing every 3 to 6 hours for severe bleeds.

Prevention of bleeding in surgical interventions or invasive procedures in hemophilia A or B with inhibitors:
90 micrograms/kg by intravenous injection immediately before surgery and every 2 hours during surgery. Post-surgical dosing: For minor procedures, dosing every 2 hours for 48 hours and then every 2 to 6 hours, and for major procedures every 2 hours for the first 5 days and then every 4 hours, until healing has occurred.

Acquired hemophilia - bleeding episodes or surgery:
70 to 90 micrograms/kg by intravenous bolus injection every 2 to 3 hours until hemostasis is achieved.

Usual Adult Dose for Factor VII Deficiency:

Congenital FVII Deficiency - Bleeding Episodes or Surgery:
15 to 30 micrograms/kg every 4 to 6 hours until hemostasis is achieved.

What other drugs will affect coagulation factor VIIa?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with coagulation factor VIIa, especially medications to treat or prevent bleeding episodes, such as:

  • anti-inhibitor coagulant complex; or

  • factor ix complex.

This list is not complete. Other drugs may interact with coagulation factor VIIa, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about coagulation factor VIIa.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 1.10. Revision Date: 2013-06-28, 3:32:10 PM.

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