Ciloxan Side Effects

Generic name: ciprofloxacin ophthalmic

Please note - some side effects for Ciloxan may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Ciloxan - for the consumer

Ciloxan Drops

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Ciloxan Drops:

Bad taste in the mouth; bloodshot eyes; crusting of eyelids; eye burning or discomfort; feeling of something in the eye; itching; sensitivity to light.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); eyelid swelling; irritation; vision changes; white crystals in the eye.

Ciloxan Ointment

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Ciloxan Ointment:

Bloodshot eyes; blurred vision; burning or discomfort; crusting of eyelids; dry eyes; feeling of something in the eye; sensitivity to light.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); eyelid swelling; irritation; vision changes.

For the professional

Ciloxan

The following adverse reactions (incidences) were reported in 2% of the patients in clinical studies for Ciloxan (ciprofloxacin hydrochloride ophthalmic ointment) : discomfort, keratopathy. Other reactions associated with ciprofloxacin therapy occurring in less than 1% of patients included allergic reactions, blurred vision, corneal staining, decreased visual acuity, dry eye, edema, epitheliopathy, eye pain, foreign body sensation, hyperemia, irritation, keratoconjunctivitis, lid erythema, lid margin hyperemia, photophobia, pruritus, and tearing.

Systemic adverse reactions related to ciprofloxacin therapy occurred at an incidence below 1% and included dermatitis, nausea and taste perversion.

Ciloxan Ophthalmic solution

The most frequently reported drug related adverse reaction was local burning or discomfort. In corneal ulcer studies with frequent administration of the drug, white crystalline precipitates were seen in approximately 17% of patients. Other reactions occurring in less than 10% of patients included lid margin crusting, crystals/scales, foreign body sensation, itching, conjunctival hyperemia and a bad taste following instillation. Additional events occurring in less than 1% of patients included corneal staining, keratopathy/keratitis, allergic reactions, lid edema, tearing, photophobia, corneal infiltrates, nausea and decreased vision.

By body system

Ocular side effects

Ocular side effects have most frequently included local burning or discomfort. In addition, white crystalline precipitates formed in the corneal defect of 17% of patients using ciprofloxacin ophthalmic solution and 13% of patients using ciprofloxacin ophthalmic ointment for corneal ulcers. Lid margin crusting, crystal or scale formation in the eye, foreign body sensation, itching, corneal hyperemia, and a bad taste following instillation of the medication has occurred in less than 10% of patients. Less than 1% of patients reported corneal staining, keratopathy, keratitis, allergic reactions, lid edema, tearing, photophobia, corneal infiltrates, decreased vision, blurred vision, dry eye, epitheliopathy, eye pain or eye irritation.

Older patients (>50 years) have a greater risk of developing a corneal precipitate, possibly due to dryer eyes or alkaline eye surfaces. The precipitate does not appear to affect ciprofloxacin's antimicrobial efficacy but may prolong epithelial healing in patients with keratitis.

Hypersensitivity side effects

Hypersensitivity has been reported in less than 1% of patients.

Dermatologic side effects

Dermatologic side effects have included dermatitis (<1%).

Gastrointestinal side effects

Gastrointestinal side effects have included nausea (<1%).

Psychiatric side effects

Psychiatric side effects have included a case of acute psychosis (visual and auditory hallucinations, irrational speech, and behavioral disturbances) following ocular administration. The symptoms resolved upon discontinuation.

Nervous system side effects

Nervous system side effects have included dizziness and lightheadedness following ocular administration.

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