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Ciloxan Side Effects

Generic Name: ciprofloxacin ophthalmic

Note: This page contains information about the side effects of ciprofloxacin ophthalmic. Some of the dosage forms included on this document may not apply to the brand name Ciloxan.

Not all side effects for Ciloxan may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to ciprofloxacin ophthalmic: ophthalmic ointment, ophthalmic solution

In addition to its needed effects, some unwanted effects may be caused by ciprofloxacin ophthalmic (the active ingredient contained in Ciloxan). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking ciprofloxacin ophthalmic, check with your doctor or nurse as soon as possible:

  • Allergic reaction, such as skin rash, hives, or itching
  • blurred vision or other change in vision
  • eye pain
  • irritation (severe) or redness of eye
  • nausea

Some of the side effects that can occur with ciprofloxacin ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Burning or other discomfort of eye
  • crusting or crystals in corner of eye
Less common
  • Bad taste following use in the eye
  • feeling of something in eye
  • itching of eye
  • redness of the lining of the eyelids
  • Dryness of eye
  • increased sensitivity of eyes to light
  • swelling of eyelid
  • tearing of eye

For Healthcare Professionals

Applies to ciprofloxacin ophthalmic: ophthalmic ointment, ophthalmic solution


Ocular side effects have most frequently included local burning or discomfort. In addition, white crystalline precipitates formed in the corneal defect of 17% of patients using ciprofloxacin ophthalmic (the active ingredient contained in Ciloxan) solution and 13% of patients using ciprofloxacin ophthalmic ointment for corneal ulcers. Lid margin crusting, crystal or scale formation in the eye, foreign body sensation, itching, corneal hyperemia, and a bad taste following instillation of the medication has occurred in less than 10% of patients. Less than 1% of patients reported corneal staining, keratopathy, keratitis, allergic reactions, lid edema, tearing, photophobia, corneal infiltrates, decreased vision, blurred vision, dry eye, epitheliopathy, eye pain or eye irritation.[Ref]

Older patients (>50 years) have a greater risk of developing a corneal precipitate, possibly due to dryer eyes or alkaline eye surfaces. The precipitate does not appear to affect ciprofloxacin's antimicrobial efficacy but may prolong epithelial healing in patients with keratitis.[Ref]


Hypersensitivity has been reported in less than 1% of patients.[Ref]


Dermatologic side effects have included dermatitis (<1%).[Ref]


Gastrointestinal side effects have included nausea (<1%).[Ref]


Psychiatric side effects have included a case of acute psychosis (visual and auditory hallucinations, irrational speech, and behavioral disturbances) following ocular administration. The symptoms resolved upon discontinuation.[Ref]

Nervous system

Nervous system side effects have included dizziness and lightheadedness following ocular administration.[Ref]


1. "Product Information. Ciloxan (ciprofloxacin ophthalmic)." Alcon Laboratories Inc, Fort Worth, TX.

2. Wilhelmus KR, Abshire RL "Corneal ciprofloxacin precipitation during bacterial keratitis." Am J Ophthalmol 136 (2003): 1032-7

3. Tripathi A, Chen SI, O'Sullivan S "Clinicopathologic reports, case reports, and small case series: acute psychosis following the use of topical ciprofloxacin." Arch Ophthalmol 120 (2002): 669-70

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