Cevimeline Side Effects

Not all side effects for cevimeline may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to cevimeline: oral capsule

In addition to its needed effects, some unwanted effects may be caused by cevimeline. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking cevimeline:

Less common
  • Difficulty breathing
  • fast heartbeat
  • itching
  • Chest pain
  • fainting or light-headedness when getting up from a lying or a sitting position
  • swelling of gums or tongue
Symptoms of Overdose

If any of the following symptoms of overdose occur while taking cevimeline, get emergency help immediately:

  • Blurring or loss of vision
  • chest pain
  • cold, clammy skin
  • diarrhea, continuous and severe
  • disturbed color vision
  • dizziness, faintness, or light-headedness when getting up from a lying or sitting position
  • difficult or labored breathing
  • fast, pounding, slow, or irregular heartbeat
  • fast, weak pulse
  • headache
  • mental confusion
  • nausea
  • pounding in ears
  • shaking or trembling of hands or feet
  • shortness of breath
  • stomach cramps or pain
  • sweating
  • tearing of the eyes

If any of the following side effects occur while taking cevimeline, check with your doctor or nurse as soon as possible:

Less common
  • Bloody or cloudy urine
  • blurred vision
  • chest pain
  • cough
  • cracks in skin
  • difficult, burning , or painful urination
  • dizziness
  • dry or itching eyes
  • earache
  • feeling of constant movement of self or surroundings
  • itching of vagina, genital, or other skin area
  • lower back pain
  • redness or pain in eye
  • ringing or buzzing in the ears
  • scaling of skin
  • shortness of breath
  • skin rash
  • soreness or redness of skin
  • sores, ulcers, or white spots on tongue, lips, or inside of mouth
  • stiffness of muscles
  • swelling of hands, ankles, feet, or lower legs
  • swelling on side of face and jaw, with or without pain
  • tense muscles

Some of the side effects that can occur with cevimeline may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Excessive sweating
  • nausea
  • runny or stuffy nose
Less common
  • Abdominal pain
  • belching
  • bloating or swelling of face, hands, feet, or lower legs
  • bloody nose
  • bone or joint pain
  • burning, dry, or itching feeling in eye
  • change in vision
  • chills
  • constipation
  • cough, mucus-producing
  • decreased touch sensation
  • depression
  • diarrhea
  • dry mouth
  • eye pain
  • feelings of warmth in face, neck, arms, and occasionally, chest
  • fever
  • heartburn
  • hiccups
  • injury
  • itching
  • leg cramps
  • loss of appetite
  • migraine headache
  • mood or mental changes
  • muscle aches, pain, or stiffness
  • pain and swelling of eye, eyelid, or inner lining of eye
  • pain on side of face and jaw
  • pain, swelling, or redness of joints
  • postoperative pain
  • rapid weight gain
  • shortness of breath
  • skin disorder
  • tightness in chest
  • tooth disorders or pain
  • trembling or shaking of hands or feet
  • trouble in sleeping
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting
  • watering of mouth
  • weight loss
  • Abnormal crying
  • deep, dark, purple bruise
  • swelling or puffiness of face
  • temperature sensation changes

For Healthcare Professionals

Applies to cevimeline: oral capsule

Nervous system

Nervous system side effects have included excess sweating (19%) and excessive salivation (2%).


Gastrointestinal side effects have included nausea (14%), diarrhea (10%), dyspepsia (8%), abdominal pain (8%), vomiting (4.6%) and cholecystitis.


General side effects have included headache (14%), injury (5%), dizziness (4%), surgical intervention (3%), fatigue (3%), pain (3%), hot flushes (2%), and insomnia (2%).


Respiratory side effects have included sinusitis (12%), upper respiratory tract infection (11%), rhinitis (11%), coughing (6%), pharyngitis (5%), and bronchitis (4%).


Genitourinary side effects have included urinary tract infection (6%) and urinary frequency (1%).


Musculoskeletal side effects have included back pain (5%), arthralgia (4%), skeletal pain (3%), and rigors (1%).


Dermatologic side effects have included rash (4%).


Ocular side effects have included conjunctivitis (4%).


Hepatic side effects including liver and biliary systems disorders and cholecystitis have been reported.

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