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Carfilzomib Side Effects

Not all side effects for carfilzomib may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to carfilzomib: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by carfilzomib. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking carfilzomib, check with your doctor or nurse immediately:

More common
  • Agitation
  • black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • confusion
  • cough or hoarseness
  • decreased urine output
  • depression
  • difficult or labored breathing
  • difficulty with moving
  • dizziness
  • drowsiness
  • fast or irregular heartbeat
  • hostility
  • irregular heartbeat
  • irritability
  • lower back or side pain
  • muscle spasms (tetany) or twitching
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • seizures
  • shortness of breath
  • stupor
  • swelling of the face, ankles, or hands
  • tightness in the chest
  • tingling of the hands or feet
  • trembling
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • wheezing
Less common
  • Chills
  • fever
  • muscle pain or cramps
  • pain in the joints
  • painful blisters on the trunk of the body
  • weakness in the arms, hands, legs, or feet

Some of the side effects that can occur with carfilzomib may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Abdominal or stomach pain
  • back pain
  • blurred vision
  • body aches or pain
  • bone pain
  • constipation
  • diarrhea
  • dry mouth
  • ear congestion
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • loss of appetite
  • loss of voice
  • metallic taste
  • muscle weakness
  • pain in the arms or legs
  • runny nose
  • sneezing
  • sore throat
  • sweating
  • trouble sleeping
  • weight loss

For Healthcare Professionals

Applies to carfilzomib: intravenous powder for injection

Hematologic

Very common (10% or more): Anemia (46.8%), thrombocytopenia (36.3%), lymphopenia (24%), neutropenia (20.7%), leukopenia (13.5%)
Postmarketing reports: Thrombocytopenic purpura/hemolytic uremic syndrome[Ref]

Cardiovascular

Very common (10% or more): Hypertension (14.3%)
Common (1% to 10%): Cardiac failure events (e.g., pulmonary edema, decreased ejection fraction)
Frequency not reported: Cardiac arrest, congestive heart failure with decreased left ventricular function or myocardial ischemia[Ref]

Hepatic

Very common (10% or more): Increased aspartate aminotransferase (12.5%)
Uncommon (0.1% to 1%): Hepatic failure
Frequency not reported: Elevated serum transaminases, elevated bilirubin

Nervous system

Very common (10% or more): Headache (27.6%), peripheral neuropathy (14%), dizziness (12.5%), hypoesthesia (12.2%)
Postmarketing reports: Posterior reversible encephalopathy syndrome[Ref]

Other

Very common (10% or more): Fatigue (55.5%), pyrexia (30.4%), peripheral edema (24%), chills (16%), arthralgia (15.8%), muscle spasms (14.4%), asthenia (13.9%), pain (12%)
Frequency not reported: Infusion reactions

Respiratory

Very common (10% or more): Dyspnea (34.6%), upper respiratory tract infection (28.3%), cough (26%), pneumonia (12.7%)
Common (1% to 10%): Pulmonary hypertension[Ref]

Oncologic

Uncommon (0.1% to 1%): Tumor lysis syndrome

Gastrointestinal

Very common (10% or more): Nausea (44.9%), diarrhea (32.7%), vomiting (22.2%), constipation (20.9%)[Ref]

Renal

Very common (10% or more): Increased blood creatinine (24.1%)
Common (1% to 10%): Renal failure[Ref]

Metabolic

Very common (10% or more): Hypokalemia (13.7%), hypomagnesemia (13.5%), anorexia (12%), hyperglycemia (11.8%), hypercalcemia (11%), hypophosphatemia (10.5%), hyponatremia (10.3%)
Postmarketing reports: Dehydration[Ref]

Musculoskeletal

Very common (10% or more): Back pain (20.2%), extremity pain (13.3%), chest wall pain (11.4%)[Ref]

General

The most common adverse reactions (30% or greater incidence) are fatigue, anemia, nausea, thrombocytopenia, dyspnea, diarrhea, and pyrexia.[Ref]

Psychiatric

Very common (10% or more): Insomnia (17.9%)

Immunologic

Common (1% to 10%): Herpes zoster reactivation[Ref]

Dermatologic

Postmarketing reports: Rash

References

1. "Product Information. Kyprolis (carfilzomib)." Onyx Pharmaceuticals Inc, South San Francisco, CA.

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