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Carfilzomib Side Effects

Not all side effects for carfilzomib may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to carfilzomib: intravenous powder for solution

In addition to its needed effects, some unwanted effects may be caused by carfilzomib. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking carfilzomib, check with your doctor or nurse immediately:

More common
  • Agitation
  • black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain
  • confusion
  • cough or hoarseness
  • decreased urine output
  • depression
  • difficult or labored breathing
  • difficulty with moving
  • dizziness
  • drowsiness
  • fast or irregular heartbeat
  • hostility
  • irregular heartbeat
  • irritability
  • lower back or side pain
  • muscle spasms (tetany) or twitching
  • nausea or vomiting
  • numbness or tingling in the hands, feet, or lips
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • seizures
  • shortness of breath
  • stupor
  • swelling of the face, ankles, or hands
  • tightness in the chest
  • tingling of the hands or feet
  • trembling
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • wheezing
Less common
  • Chills
  • fever
  • muscle pain or cramps
  • pain in the joints
  • painful blisters on the trunk of the body
  • weakness in the arms, hands, legs, or feet

Some of the side effects that can occur with carfilzomib may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Abdominal or stomach pain
  • back pain
  • blurred vision
  • body aches or pain
  • bone pain
  • constipation
  • diarrhea
  • dry mouth
  • ear congestion
  • flushed, dry skin
  • fruit-like breath odor
  • headache
  • increased hunger
  • increased thirst
  • increased urination
  • loss of appetite
  • loss of voice
  • metallic taste
  • muscle weakness
  • pain in the arms or legs
  • runny nose
  • sneezing
  • sore throat
  • sweating
  • trouble sleeping
  • weight loss

For Healthcare Professionals

Applies to carfilzomib: intravenous powder for injection

Cardiovascular

Cardiovascular side effects have included peripheral edema (24.0%), hypertension (14.3%), and congestive heart failure.

Gastrointestinal

Gastrointestinal side effects have included nausea (44.9%), diarrhea (32.7%), vomiting (22.2%), constipation (20.9%), and neutropenia (20.7%).

General

General side effects have included fatigue (55.5%), pyrexia (30.4%), insomnia (17.9%), chills (16.0%), asthenia (13.9%), pain in extremity (13.3%), anorexia (12.0%), and pain (12.0%).

Hematologic

Hematologic side effects have included anemia (46.8%), thrombocytopenia (36.3%), lymphopenia (24.0%), and leukopenia (13.5%).

Immunologic

Immunologic side effects have included herpes zoster reactivation (2%).

Metabolic

Laboratory abnormalities have included increased blood creatinine (24.1%), hypokalemia (13.7%), hypomagnesemia (13.5%), increased aspartate aminotransferase (12.5%), hyperglycemia (11.8%), hypercalcemia (11.0%), hypophosphatemia (10.5%), and hyponatremia (10.3%).

Musculoskeletal

Musculoskeletal side effects have included back pain (20.2%), arthralgia (15.8%), muscle spasms (14.4%), and chest wall pain (11.4%).

Nervous system

Nervous system side effects have included headache (27.6%), peripheral neuropathy (14%), dizziness (12.5%), and hypoesthesia (12.2%).

Renal

Renal side effects have included renal failure (9%).

Respiratory

Respiratory side effects have included dyspnea (34.6%), upper respiratory tract infection (28.3%), cough (26.0%), and pneumonia (12.7%).

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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