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Proteasome inhibitors

A drug may be classified by the chemical type of the active ingredient or by the way it is used to treat a particular condition. Each drug can be classified into one or more drug classes.

Proteasomes are protease complexes which are responsible for degrading endogenous proteins. Proteins to be destroyed are recognized by proteasomes because of the presence of ubiquitin conjugated to the targeted protein. The ubiquitin-proteasome pathway plays an essential role in regulating the intracellular concentration of specific proteins, thereby maintaining homeostasis within cells. Proteasome inhibitors prevent this targeted decomposition of protein, which can affect multiple signaling cascades within the cell. This disruption of normal homeostatic mechanisms can lead to cell death. Proteasome inhibitors may be used to treat multiple myeloma and certain types of lymphoma.

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Drug Name DownUp( View by: Brand | Generic ) Reviews Ratings DownUp
Velcade (Pro, More...)
generic name: bortezomib
2 reviews
Kyprolis (Pro, More...)
generic name: carfilzomib
0 reviews

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Medical conditions associated with proteasome inhibitors: