Generic Name: carfilzomib (kar FILZ oh mib)
Brand Names: Kyprolis
What is Kyprolis?
Kyprolis (carfilzomib) is a cancer medication that interferes with the growth and spread of cancer cells in the body.
Kyprolis is used to treat multiple myeloma. It is usually given after at least two other cancer medications have been tried without success.
Kyprolis may also be used for purposes not listed in this medication guide.
Kyprolis can affect your heart or lungs. Call your doctor at once if you have chest pain, pounding heartbeats, shortness of breath (even with mild exertion or while lying down), swelling of your hands or feet, pounding heartbeats or fluttering in your chest, feeling like you might pass out, wheezing, gasping for breath, cough with foamy mucus, or blue colored appearance of your lips and skin.
Before receiving Kyprolis
You should not use Kyprolis if you are allergic to carfilzomib.
To make sure Kyprolis is safe for you, tell your doctor if you have:
kidney disease (or if you are on dialysis);
heart disease; or
liver disease, or abnormal liver function tests.
FDA pregnancy category D. Do not use Kyprolis if you are pregnant. It could harm the unborn baby. Use effective birth control to avoid pregnancy during your treatment with Kyprolis. Follow your doctor's instructions about how long to prevent pregnancy after your treatment ends.
See also: Pregnancy and breastfeeding warnings (in more detail)
It is not known whether carfilzomib passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using Kyprolis.
How is Kyprolis given?
Kyprolis is injected into a vein through an IV. A healthcare provider will give you this injection.
Kyprolis is given in a 28-day treatment cycle. You will receive an injection only on certain days of this cycle.
Your doctor will determine how many treatment cycles you should receive.
You may be given medication to prevent certain side effects while you are receiving Kyprolis. Drink plenty of liquids before and after your Kyprolis injections.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while receiving Kyprolis.
You may need frequent medical tests to be sure Kyprolis is not causing harmful effects. Your cancer treatments may be delayed based on the results of these tests.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid?
Carfilzomib can pass into body fluids (including urine, feces, vomit, semen, vaginal fluid). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Patients and caregivers should wear rubber gloves while cleaning up body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Body fluids should not be handled by a woman who is pregnant or who may become pregnant. Use condoms during sexual activity to avoid exposure to body fluids.
Kyprolis may cause you to feel light-headed or short of breath. Be careful if you drive or do anything that requires you to be alert.
Kyprolis side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Kyprolis: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Some side effects may occur within 24 hours after the Kyprolis injection. Tell your caregiver right away if you feel dizzy, weak, nauseated, light-headed, feverish, sweaty, or if you have joint or muscle pain, a headache, chest tightness, back pain, trouble breathing, or swelling in your face.
Call your doctor at once if you have:
shortness of breath (even with mild exertion or while lying down), swelling of your hands or feet;
anxiety, sweating, pale skin, wheezing, gasping for breath, cough with foamy mucus, fast or uneven heart rate;
chest pain spreading to the arm or jaw, sweating, general ill feeling;
pounding heartbeats or fluttering in your chest, feeling like you might pass out;
blue colored appearance of your lips and skin;
fever, swollen gums, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;
easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;
slow heart rate, weak pulse, confusion, lower back pain, blood in your urine;
little or no urinating;
numbness or tingly feeling around your mouth or in your hands and feet;
muscle weakness, tightness, or contraction, overactive reflexes; or
upper stomach pain, loss of appetite, dark urine, jaundice (yellowing of the skin or eyes).
Common Kyprolis side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Kyprolis?
Other drugs may interact with Kyprolis, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Where can I get more information?
- Your pharmacist can provide more information about Kyprolis.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Kyprolis only for the indication prescribed.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2014 Cerner Multum, Inc. Version: 1.02. Revision Date: 2013-07-12, 1:22:13 PM.