Cabazitaxel Side Effects

Not all side effects for cabazitaxel may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to cabazitaxel: intravenous solution

Along with its needed effects, cabazitaxel may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking cabazitaxel:

More common
  • Black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • burning, numbness, tingling, or painful sensations
  • chest pain
  • chills
  • cough
  • difficult or labored breathing
  • difficult or painful urination
  • fever
  • lower back or side pain
  • pale skin
  • pinpoint red spots on the skin
  • rapid weight gain
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • tightness in the chest
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • weakness in the arms, hands, legs, or feet
Less common
  • Blurred vision
  • confusion
  • decreased urination
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fainting
  • fast, slow, or irregular heartbeat
  • lightheadedness
  • rapid breathing
  • sunken eyes
  • sweating
  • thirst
  • wrinkled skin

Some side effects of cabazitaxel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common
  • Abdominal or stomach pain
  • acid or sour stomach
  • belching
  • change in taste
  • constipation
  • cracked lips
  • decreased weight
  • diarrhea
  • difficulty with swallowing
  • hair loss
  • headache
  • heartburn
  • indigestion
  • lack or loss of strength
  • loss of appetite
  • nausea
  • stomach discomfort, upset, or pain
  • thinning of the hair
  • vomiting
  • weight loss
Less common
  • Back pain
  • difficulty with moving
  • muscle pain or stiffness
  • muscle spasms
  • pain in the joints
  • pain, itching, burning, swelling, or a lump under your skin where the needle is placed

For Healthcare Professionals

Applies to cabazitaxel: intravenous solution

General

In general, the most common grade 3 to 4 adverse effects were neutropenia, leucopenia, anemia, diarrhea, fatigue, and asthenia. The most common adverse effects leading to treatment discontinuation were neutropenia and renal failure.

Hematologic

Hematologic side effects have included anemia (98%), leucopenia (96%), neutropenia (94%), thrombocytopenia (48%), and febrile neutropenia (7%).

Gastrointestinal

Gastrointestinal side effects have included diarrhea (47%), nausea (34%), vomiting (22%), constipation (20%), abdominal pain (17%), anorexia (16%), dysgeusia (11%), and dyspepsia (10%).

Cardiovascular

Cardiovascular side effects have included peripheral edema (9%), arrhythmias (5%), and hypotension (5%).

Dermatologic

Dermatologic side effects have included alopecia (10%).

Genitourinary

Genitourinary side effects have included hematuria (17%), urinary tract infection (8%), and dysuria (7%).

Hepatic

Hepatic side effects have included increased transaminases and increased bilirubin.

Hypersensitivity

Hypersensitivity reactions have included rash, erythema, hypotension, and bronchospasm.

Metabolic

Metabolic side effects have included weight loss (9%) and dehydration (5%).

Musculoskeletal

Musculoskeletal side effects have included back pain (16%), arthralgia (11%), and muscle spasms (7%).

Nervous system

Nervous system side effects have included peripheral neuropathy (13%), dizziness (8%), and headache (8%).

Other

Other side effects have included fatigue (37%), asthenia (20%), pyrexia (12%), mucosal inflammation (6%), and pain (5%).

Renal

Renal side effects have included renal failure.

Respiratory

Respiratory side effects have included dyspnea (12%) and cough (11%).

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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