Cabazitaxel Side Effects
Some side effects of cabazitaxel may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to cabazitaxel: intravenous solution
Along with its needed effects, cabazitaxel may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking cabazitaxel:More common
- Black, tarry stools
- bleeding gums
- bloating or swelling of the face, arms, hands, lower legs, or feet
- blood in the urine or stools
- burning while urinating
- burning, numbness, tingling, or painful sensations
- chest pain
- difficult or labored breathing
- difficult or painful urination
- lower back or side pain
- pale skin
- pinpoint red spots on the skin
- rapid weight gain
- shortness of breath
- sore throat
- sores, ulcers, or white spots on the lips or in the mouth
- swollen glands
- tightness in the chest
- tingling of the hands or feet
- troubled breathing with exertion
- unsteadiness or awkwardness
- unusual bleeding or bruising
- unusual tiredness or weakness
- unusual weight gain or loss
- weakness in the arms, hands, legs, or feet
- Blurred vision
- decreased urination
- dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
- dry mouth
- fast, slow, or irregular heartbeat
- increase in heart rate
- rapid breathing
- sunken eyes
- wrinkled skin
Some side effects of cabazitaxel may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Abdominal or stomach pain
- acid or sour stomach
- change in taste
- cracked lips
- decreased weight
- difficulty with swallowing
- hair loss
- lack or loss of strength
- loss of appetite
- stomach discomfort, upset, or pain
- thinning of the hair
- weight loss
- Back pain
- difficulty with moving
- muscle pain or stiffness
- muscle spasms
- pain in the joints
- pain, itching, burning, swelling, or a lump under your skin where the needle is placed
For Healthcare Professionals
Applies to cabazitaxel: intravenous solution
In general, the most common grade 3 to 4 adverse effects were neutropenia, leucopenia, anemia, diarrhea, fatigue, and asthenia. The most common adverse effects leading to treatment discontinuation were neutropenia and renal failure.
Hematologic side effects have included anemia (98%), leucopenia (96%), neutropenia (94%), thrombocytopenia (48%), and febrile neutropenia (7%).
Gastrointestinal side effects have included diarrhea (47%), nausea (34%), vomiting (22%), constipation (20%), abdominal pain (17%), anorexia (16%), dysgeusia (11%), and dyspepsia (10%).
Cardiovascular side effects have included peripheral edema (9%), arrhythmias (5%), and hypotension (5%).
Dermatologic side effects have included alopecia (10%).
Genitourinary side effects have included hematuria (17%), urinary tract infection (8%), and dysuria (7%).
Hepatic side effects have included increased transaminases and increased bilirubin.
Hypersensitivity reactions have included rash, erythema, hypotension, and bronchospasm.
Metabolic side effects have included weight loss (9%) and dehydration (5%).
Musculoskeletal side effects have included back pain (16%), arthralgia (11%), and muscle spasms (7%).
Nervous system side effects have included peripheral neuropathy (13%), dizziness (8%), and headache (8%).
Other side effects have included fatigue (37%), asthenia (20%), pyrexia (12%), mucosal inflammation (6%), and pain (5%).
Renal side effects have included renal failure.
Respiratory side effects have included dyspnea (12%) and cough (11%).
More cabazitaxel resources
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