Generic Name: cabazitaxel (ka BAZ i TAX el)
Brand Names: Jevtana
What is Jevtana?
Jevtana (cabazitaxel) is a cancer medication that interferes with the growth and spread of cancer cells in the body.
Jevtana is used together with prednisone to treat prostate cancer that has spread to other parts of the body (metastatic). It is usually given after other cancer medicines have been tried without successful treatment.
Jevtana may also be used for purposes not listed in this medication guide.
Do not use Jevtana if you are pregnant. It could harm the unborn baby. You should not use this medication if you are allergic to cabazitaxel, or if you have liver disease, low white blood cell counts, or an allergy to any medicine that contains polysorbate 80. You should not breast-feed while you are receiving Jevtana.
Before you receive Jevtana, tell your doctor if you have ever had a severe allergic reaction to any medication.
Jevtana is used together with prednisone, and you may also be given other medications to help prevent certain side effects. Use all medications as directed by your doctor.
To make sure Jevtana is helping your condition and not causing harmful effects, your blood will need to be tested often.
Before receiving Jevtana
You should not use Jevtana if you are allergic to cabazitaxel, or if you have:
low white blood cell counts; or
an allergy to any medicine that contains polysorbate 80.
To make sure you can safely receive Jevtana, tell your doctor if you have ever had a severe allergic reaction to any medication.
FDA pregnancy category D. Do not use Jevtana if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment. It is not known whether cabazitaxel passes into breast milk or if it could harm a nursing baby. You should not breast-feed while you are receiving this medicine. Serious side effects may be more likely in older adults receiving Jevtana.
See also: Pregnancy and breastfeeding warnings (in more detail)
How is Jevtana given?
Jevtana is injected into a vein through an IV. You will receive this injection in a clinic or hospital setting. The injection must be given slowly, and the IV infusion can take about 1 hour to complete.
Jevtana is usually given once every 3 weeks. You will most likely take prednisone by mouth every day throughout your treatment. Follow your doctor's dosing instructions very carefully.
Do not stop taking prednisone without your doctor's advice, or you could have unpleasant side effects caused by Jevtana. Tell your doctor if you have missed any doses or have stopped taking prednisone for any reason.
About 30 minutes before you receive Jevtana, you may be given other medications to help prevent certain side effects.
Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice.
To make sure Jevtana is helping your condition and not causing harmful effects, your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests. Do not miss any follow-up visits to your doctor.
Your doctor may tell you to check your temperature at home throughout your treatment with Jevtana.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while receiving Jevtana, which can lead to a serious electrolyte imbalance.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your Jevtana injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include some of the serious side effects listed in this medication guide.
What should I avoid?
Avoid taking an herbal supplement containing St. John's wort while you are being treated with Jevtana.
Jevtana side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Jevtana: hives, red skin rash; difficult breathing; feeling light-headed; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
fever, cough, chills, muscle aches, flu symptoms, sores in your mouth and throat, rapid and shallow breathing, fainting;
pale skin, feeling light-headed or short of breath, rapid heart rate, trouble concentrating;
severe or ongoing diarrhea;
feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin;
swelling or rapid weight gain; or
blood in your urine, pain or burning when you urinate.
Less serious Jevtana side effects may include:
nausea, vomiting, stomach pain;
constipation, mild diarrhea;
weakness, tired feeling;
joint pain, back pain;
numbness, burning pain, or tingly feeling en your hands or feet;
changes in your sense of taste; or
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Side effects (in more detail)
What other drugs will affect Jevtana?
Many drugs can interact with Jevtana. Below is just a partial list. Tell your doctor if you are using:
isoniazid (for treating tuberculosis);
cyclosporine (Gengraf, Neoral, Sandimmune);
an antibiotic such as clarithromycin (Biaxin), dalfopristin/quinupristin (Synercid), doxycycline (Adoxa, Alodox, Avidoxy, Oraxyl, Doryx, Oracea, Vibramycin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin), metronidazole (Flagyl), norfloxacin (Noroxin), telithromycin (Ketek), or tetracycline (Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap);
antifungal medication such as clotrimazole (Mycelex Troche), fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Extina, Ketozole, Nizoral, Xolegal), or voriconazole (Vfend);
an antidepressant such as nefazodone, desipramine (Norpramin), or sertraline (Zoloft);
heart or blood pressure medication such as amiodarone (Cordarone, Pacerone), diltiazem (Cartia, Cardizem), felodipine (Plendil), nifedipine (Nifedical, Procardia), verapamil (Calan, Covera, Isoptin, Verelan), and others; or
HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir).
This list is not complete and there are many other drugs that can interact with Jevtana. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
More about Jevtana (cabazitaxel)
Related treatment guides
Where can I get more information?
- Your doctor or pharmacist can provide more information about Jevtana.
- Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.
Copyright 1996-2014 Cerner Multum, Inc. Version: 1.01. Revision Date: 10/18/2010 9:51:10 AM.