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Jevtana Side Effects

Generic Name: cabazitaxel

Note: This page contains information about the side effects of cabazitaxel. Some of the dosage forms included on this document may not apply to the brand name Jevtana.

Not all side effects for Jevtana may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to cabazitaxel: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by cabazitaxel (the active ingredient contained in Jevtana). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking cabazitaxel, check with your doctor or nurse immediately:

More common
  • Black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • burning, numbness, tingling, or painful sensations
  • chest pain
  • chills
  • cough
  • difficult or labored breathing
  • difficult or painful urination
  • fever
  • lower back or side pain
  • pale skin
  • pinpoint red spots on the skin
  • rapid weight gain
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swollen glands
  • tightness in the chest
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss
  • weakness in the arms, hands, legs, or feet
Less common
  • Blurred vision
  • confusion
  • decreased urination
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fainting
  • fast, slow, or irregular heartbeat
  • lightheadedness
  • rapid breathing
  • sunken eyes
  • sweating
  • thirst
  • wrinkled skin

Some of the side effects that can occur with cabazitaxel may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Abdominal or stomach pain
  • acid or sour stomach
  • belching
  • change in taste
  • constipation
  • cracked lips
  • decreased weight
  • diarrhea
  • difficulty with swallowing
  • hair loss
  • headache
  • heartburn
  • indigestion
  • lack or loss of strength
  • loss of appetite
  • nausea
  • stomach discomfort, upset, or pain
  • thinning of the hair
  • vomiting
  • weight loss
Less common
  • Back pain
  • difficulty with moving
  • muscle pain or stiffness
  • muscle spasms
  • pain in the joints
  • pain, itching, burning, swelling, or a lump under your skin where the needle is placed

For Healthcare Professionals

Applies to cabazitaxel: intravenous solution


The most common adverse events were anemia, leukopenia, neutropenia, thrombocytopenia, and diarrhea.[Ref]


Very common (10% or more): Anemia (98%), leukopenia (96%), neutropenia (94%), thrombocytopenia (48%)
Common (1% to 10%): Febrile neutropenia[Ref]


Very common (10% or more): Diarrhea (47%), nausea (34%), vomiting (22%), constipation (20%), abdominal pain (17%), dyspepsia (10%)
Common (1% to 10%): Abdominal pain upper, hemorrhoids, gastroesophageal reflux disease, rectal hemorrhage, dry mouth, abdominal distension
Frequency not reported: Death related to diarrhea and electrolyte imbalance, GI hemorrhage and perforation, ileus, enterocolitis, neutropenic enterocolitis, colitis
Postmarketing reports: Gastritis, intestinal obstruction[Ref]

Nervous system

Very common (10% or more): Fatigue (37%), dysgeusia (11%)
Common (1% to 10%): Dizziness, peripheral neuropathy, headache, peripheral sensory neuropathy, paresthesia, lethargy, hypoesthesia, tinnitus, vertigo, sciatica
Frequency not reported: Peripheral motor neuropathy, fatal cerebral hemorrhage[Ref]


Very common (10% or more): Asthenia (20%), pyrexia (12%)
Common (1% to 10%): Mucosal inflammation, pain, death due to causes other than disease progression, malaise[Ref]


Very common (10% or more): Dyspnea (12%), cough (11%)
Common (1% to 10%): Oropharyngeal pain[Ref]


Common (1% to 10%): Peripheral edema, arrhythmia, hypotension, deep vein thrombosis, hypertension, tachycardia, grade 3 or higher arrhythmias, orthostatic hypotension, hot flush, flushing, atrial fibrillation
Uncommon (0.1% to 1%): Cardiac failure, cardiac arrest, fatal ventricular fibrillation[Ref]


Uncommon (0.1% to 1%): Grade 3 to 4 increased AST, grade 3 to 4 increased ALT, increased bilirubin
Frequency not reported: Fatal renal failure[Ref]


Very common (10% or more): Anorexia (16%)
Common (1% to 10%): Weight decreased, dehydration, edema, hyperglycemia, hypokalemia[Ref]


Very common (10% or more): Hematuria (17%)
Common (1% to 10%): Dysuria, pollakiuria, urinary retention, urinary incontinence, ureteric obstruction, pelvic pain[Ref]


Common (1% to 10%): AST increased, transaminases increased
Uncommon (0.1% to 1%): ALT increased, bilirubin increased[Ref]


Common (1% to 10%): Hypersensitivity[Ref]


Very common (10% or more): Back pain (16%), arthralgia (10.5%)
Common (1% to 10%): Pain in extremity, muscle spasms, myalgia, musculoskeletal chest pain, flank pain, chills[Ref]


Common (1% to 10%): Urinary tract infection, influenza, cystitis, upper respiratory tract infection, pneumonia, cellulitis, herpes zoster, septic shock, sepsis, candidiasis
Uncommon (0.1% to 1%): Neutropenic sepsis, neutropenic infections
Frequency not reported: Fatal infection[Ref]


Very common (10% or more): Alopecia (10%)
Common (1% to 10%): Dry skin, erythema[Ref]


Common (1% to 10%): Conjunctivitis, increased lacrimation[Ref]


Common (1% to 10%): Anxiety, confusional state[Ref]


1. "Product Information. Jevtana (cabazitaxel)." sanofi-aventis , Bridgewater, NJ.

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

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