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Armodafinil Side Effects

In Summary

Commonly reported side effects of armodafinil include: headache. Other side effects include: insomnia, skin rash, nausea, anxiety, and xerostomia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to armodafinil: oral tablet

In addition to its needed effects, some unwanted effects may be caused by armodafinil. In the event that any of these side effects do occur, they may require medical attention.

Severity: Major

You should check with your doctor immediately if any of these side effects occur when taking armodafinil:

Less common
  • Blistering, burning, crusting, dryness, or flaking of the skin
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • difficult or labored breathing
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • frequent urination
  • headache, severe and throbbing
  • increased volume of pale, dilute urine
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • rash
  • shakiness in the legs, arms, hands, or feet
  • shortness of breath
  • tightness in the chest
  • trembling or shaking of the hands or feet
  • wheezing

If any of the following symptoms of overdose occur while taking armodafinil, get emergency help immediately:

Symptoms of overdose
  • Anxiety
  • blurred vision
  • chest pain or discomfort
  • confusion about identity, place, and time
  • diarrhea
  • dry mouth
  • headache
  • hyperventilation
  • irritability
  • lightheadedness, dizziness, or fainting
  • nausea
  • nervousness
  • pounding in the ears
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • sleeplessness
  • slow heartbeat
  • trouble sleeping
  • unable to sleep
  • unusual tiredness or weakness

Severity: Minor

Some of the side effects that can occur with armodafinil may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Acid or sour stomach
  • belching
  • chills
  • cough
  • depression
  • difficulty having a bowel movement (stool)
  • discouragement
  • feeling sad or empty
  • general feeling of discomfort or illness
  • heartburn
  • indigestion
  • joint pain
  • loss of appetite
  • loss of interest or pleasure
  • mood or mental changes
  • muscle aches and pains
  • runny nose
  • shivering
  • sore throat
  • stomach discomfort, upset, or pain
  • sweating
  • thirst
  • tiredness
  • trouble concentrating
  • vomiting
  • weight loss

For Healthcare Professionals

Applies to armodafinil: oral tablet

Dermatologic

Common (1% to 10%): Rash, contact dermatitis, hyperhidrosis[Ref]

Immunologic

Common (1% to 10%): Seasonal allergy
Frequency not reported: Angioedema, anaphylaxis[Ref]

Psychiatric

Common (1% to 10%): Insomnia, anxiety, depression, agitation, depressed mood, disturbance in attention, nervousness
Frequency not reported: Irritability, suicidal ideation[Ref]

Cardiovascular

Common (1% to 10%): Palpitations, increased heart rate, increased blood pressure[Ref]

Gastrointestinal

Common (1% to 10%): Nausea, diarrhea, dry mouth, dyspepsia, upper abdominal pain, constipation, vomiting, loose stools[Ref]

General

The following reactions occurred more frequently with the 250 mg/day dose compared to the 150 mg/day dose: headache, rash, depression, dry mouth, insomnia, nausea.[Ref]

Genitourinary

Common (1% to 10%): Polyuria[Ref]

Hematologic

Frequency not reported: Pancytopenia[Ref]

Hepatic

Common (1% to 10%): Increased gamma-glutamyltransferase, increased alkaline phosphatase
Rare (less than 0.1%): Elevated AST and/or ALT[Ref]

Metabolic

Common (1% to 10%): Anorexia, decreased appetite,
Frequency not reported: Decreased serum uric acid[Ref]

Nervous system

Very common (10% or more): Headache (17%)
Common (1% to 10%): Dizziness, paresthesia, tremor, migraine[Ref]

Other

Common (1% to 10%): Fatigue, influenza-like illness, pain, pyrexia, thirst[Ref]

Respiratory

Common (1% to 10%): Dyspnea[Ref]

References

1. "Product Information. Nuvigil (armodafinil)." Cephalon Inc, West Chester, PA.

Not all side effects for armodafinil may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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