Armodafinil Side Effects

Not all side effects for armodafinil may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to armodafinil: oral tablet

In addition to its needed effects, some unwanted effects may be caused by armodafinil. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking armodafinil:

Less common
  • Blistering, burning, crusting, dryness, or flaking of the skin
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • difficult or labored breathing
  • fast, irregular, pounding, or racing heartbeat or pulse
  • fever
  • frequent urination
  • headache, severe and throbbing
  • increased volume of pale, dilute urine
  • itching, scaling, severe redness, soreness, or swelling of the skin
  • rash
  • shakiness in the legs, arms, hands, or feet
  • shortness of breath
  • tightness in the chest
  • trembling or shaking of the hands or feet
  • wheezing

If any of the following symptoms of overdose occur while taking armodafinil, get emergency help immediately:

Symptoms of overdose
  • Anxiety
  • blurred vision
  • chest pain or discomfort
  • confusion about identity, place, and time
  • diarrhea
  • dry mouth
  • headache
  • hyperventilation
  • irritability
  • lightheadedness, dizziness, or fainting
  • nausea
  • nervousness
  • pounding in the ears
  • restlessness
  • seeing, hearing, or feeling things that are not there
  • sleeplessness
  • slow heartbeat
  • trouble sleeping
  • unable to sleep
  • unusual tiredness or weakness

Some of the side effects that can occur with armodafinil may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

Less common
  • Acid or sour stomach
  • belching
  • chills
  • cough
  • depression
  • difficulty having a bowel movement (stool)
  • discouragement
  • feeling sad or empty
  • general feeling of discomfort or illness
  • heartburn
  • indigestion
  • joint pain
  • loss of appetite
  • loss of interest or pleasure
  • mood or mental changes
  • muscle aches and pains
  • runny nose
  • shivering
  • sore throat
  • stomach discomfort, upset, or pain
  • sweating
  • thirst
  • tiredness
  • trouble concentrating
  • vomiting
  • weight loss

For Healthcare Professionals

Applies to armodafinil: oral tablet

General

In general, armodafinil has been well tolerated and most side effects have been mild to moderate in severity.

Cardiovascular

Cardiovascular side effects have included palpitations (2%) and tachycardia (1%).

Gastrointestinal

Gastrointestinal side effects have frequently included nausea (7%), diarrhea (4%), dry mouth (4%), dyspepsia (2%), and upper abdominal pain (2%). Constipation, vomiting, anorexia, decreased appetite, and loose stools have been reported in 1% of patients.

Nervous system

Nervous system side effects have included headache (17%), dizziness (5%), insomnia (5%), tremor (1%), migraine headache (1%), paresthesia (1%), and disturbance in attention (1%).

Other

Other side effects have included fatigue (2%), thirst (1%), influenza-like illness (1%), fever (1%), and pain (1%).

Psychiatric

Psychiatric side effects have included anxiety (4%), depression (2%), agitation (1%), nervousness (1%), and depressed mood (1%). Postmarketing adverse events associated with the use of modafinil have included aggression.

Genitourinary

Genitourinary side effects have included polyuria (1%).

Respiratory

Respiratory side effects have included dyspnea (1%).

Dermatologic

Dermatologic side effects have included rash (2%), contact dermatitis (1%), and hyperhydrosis (1%). Serious rash requiring hospitalization and discontinuation of treatment has been reported in adults in association with the use of modafinil and armodafinil.

Hematologic

Hematologic side effects include a single case of mild pancytopenia that resolved following discontinuation of armodafinil.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.

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