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AK-Spore HC Otic Suspension Side Effects

Generic Name: hydrocortisone / neomycin / polymyxin b otic

Note: This page contains information about the side effects of hydrocortisone / neomycin / polymyxin b otic. Some of the dosage forms included on this document may not apply to the brand name AK-Spore HC Otic Suspension.

Not all side effects for AK-Spore HC Otic Suspension may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to hydrocortisone / neomycin / polymyxin b otic: otic solution, otic suspension

In addition to its needed effects, some unwanted effects may be caused by hydrocortisone / neomycin / polymyxin b otic. In the event that any of these side effects do occur, they may require medical attention.

You should check with your doctor immediately if any of these side effects occur when taking hydrocortisone / neomycin / polymyxin b otic:

More common
  • Itching, skin rash, redness, swelling, or other sign of irritation in or around the ear not present before use of this medicine

For Healthcare Professionals

Applies to hydrocortisone / neomycin / polymyxin b otic: otic solution, otic suspension


Hypersensitivity reactions associated with the anti-infective component of this drug include allergic sensitization manifested by itching and swelling. More serious reactions such as anaphylaxis have rarely been reported.[Ref]

Neomycin is known to cause contact sensitivity.[Ref]


Dermatologic side effects associated with the use of topical corticosteroids have included burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, and miliaria.[Ref]


Stinging and burning have been rarely reported when this drug has entered the middle ear.[Ref]

Nervous system

Neomycin-polymyxin B containing ear drops contributed to sensorineural hearing loss in chronic otitis media patients receiving treatment for extended periods of time.[Ref]


1. Prystowsky SD, Allen AM, Smith RW, Nonomura JH, Odom RB, Akers WA "Allergic contact hypersensitivity to nickel, neomycin, ethylenediamine, and benzocaine. Relationships between age, sex, history of exposure, and reactivity to standard patch tests and use tests in a general population." Arch Dermatol 115 (1979): 959-62

2. Prystowsky SD, Nonomura JH, Smith RW, Allen AM "Allergic hypersensitivity to neomycin. Relationship between patch test reactions and 'use' tests." Arch Dermatol 115 (1979): 713-5

3. "Product Information. Cortisporin Otic (hydrocortisone/neomycin/polymyxin B otic)" Monarch Pharmaceuticals Inc, Bristol, TN.

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