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ceftazidime injection

Pronunciation

Generic Name: ceftazidime injection (sef TAY zi deem)
Brand Name: Fortaz, Tazicef, ...show all 8 brand names

What is ceftazidime injection?

Ceftazidime is in a group of drugs called cephalosporin (SEF a low spor in) antibiotics. It works by fighting bacteria in your body.

Ceftazidime injection is used to treat many kinds of bacterial infections, including severe or life-threatening forms.

Ceftazidime may also be used for purposes not listed in this medication guide.

What is the most important information I should know about ceftazidime injection?

Do not use this medication if you are allergic to ceftazidime, or to similar antibiotics, such as Ceclor, Ceftin, Cefzil, Duricef, Keflex, Omnicef, Spectracef, Suprax, and others.

Before using this medication, tell your doctor if you have liver or kidney disease, diabetes, heart failure, cancer, a stomach or intestinal disorder, if you are malnourished, or if you are allergic to penicillin.

Ceftazidime can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using ceftazidime.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Ceftazidime will not treat a viral infection such as the common cold or flu.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or has blood in it, call your doctor. Do not use any medicine to stop the diarrhea unless your doctor has told you to.

This medication can cause unusual results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using ceftazidime.

What should I discuss with my health care provider before using ceftazidime injection?

You should not use this medication if you are allergic to ceftazidime, or to similar antibiotics, such as:

  • cefaclor (Ceclor);

  • cefadroxil (Duricef);

  • cefazolin (Ancef);

  • cefdinir (Omnicef);

  • cefditoren (Spectracef);

  • cefprozil (Cefzil);

  • ceftibuten (Cedax);

  • cefuroxime (Ceftin);

  • cephradine (Velosef);

  • cephalexin (Keflex); and others.

To make sure you can safely use ceftazidime, tell your doctor if you have any of these other conditions:

  • kidney disease;

  • liver disease;

  • a stomach or intestinal disorder such as colitis;

  • diabetes;

  • congestive heart failure;

  • if you are allergic to penicillin;

  • cancer;

  • if you are malnourished; or

  • if you have had a very recent surgery or medical emergency.

FDA pregnancy category B. This medication is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment.

Ceftazidime can make birth control pills less effective. Ask your doctor about using a non-hormone method of birth control (such as a condom, diaphragm, spermicide) to prevent pregnancy while using ceftazidime.

Ceftazidime can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I use ceftazidime injection?

Ceftazidime is injected into a muscle or vein. You may be shown how to use injections at home. Do not self-inject this medicine if you do not fully understand how to give the injection and properly dispose of used needles, syringes, and other items used in giving the medicine.

Use exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

You may need to mix ceftazidime with a liquid (diluent) before using it. If you are using the injections at home, be sure you understand how to properly mix and store the medication.

Use this medicine for the full prescribed length of time. Your symptoms may improve before the infection is completely cleared. Skipping doses may also increase your risk of further infection that is resistant to antibiotics. Ceftazidime will not treat a viral infection such as the common cold or flu.

This medication can cause unusual results with certain lab tests for glucose (sugar) in the urine. Tell any doctor who treats you that you are using ceftazidime.

Store at room temperature away from moisture and heat.

If your medicine was provided in a frozen form or was frozen after mixing, thaw it in a refrigerator or at room temperature. Do not warm in a microwave or boiling water. Use the medicine as soon as possible after thawing it. Do not refreeze.

What happens if I miss a dose?

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

If you are receiving this medication at a clinic, call your doctor if you miss an appointment for your injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include muscle stiffness, restless feeling, confusion, uncontrolled movement of the hands, seizure, and coma.

What should I avoid while using ceftazidime injection?

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop taking ceftazidime and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Ceftazidime injection side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have a serious side effect such as:

  • diarrhea that is watery or bloody;

  • swelling, pain, or irritation where the injection was given;

  • cold feeling, discoloration, or skin changes in your fingers;

  • seizure (black-out or convulsions);

  • white patches or sores inside your mouth or on your lip;

  • jaundice (yellowing of the eyes or skin); or

  • severe skin reaction -- fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain, followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Less serious side effects may include:

  • nausea, vomiting, diarrhea, stomach pain;

  • headache, dizziness;

  • numbness or tingly feeling; or

  • vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Ceftazidime injection Dosing Information

Usual Adult Dose for Bacteremia:

2 g IV every 8 hours for 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Meningitis:

2 g IV every 8 hours for 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Sepsis:

2 g IV every 8 hours for 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Endocarditis:

2 g IV every 8 hours

Treatment may be required for 6 weeks or more, depending on the nature and severity of the infection.

Usual Adult Dose for Endometritis:

2 g IV or IM every 8 hours

Parenteral therapy should be continued for at least 24 hours after the patient has remained afebrile, pain free, and the leukocyte count has normalized. Doxycycline therapy for 14 days is recommended if concurrent chlamydial infection is present in late postpartum patients (breast-feeding should be discontinued).

Usual Adult Dose for Febrile Neutropenia:

2 g IV every 8 hours

Therapy should be continued for approximately 14 days, or until more specific therapy may be substituted for a proven infection, or until the patient is afebrile for 24 hours after the absolute neutrophil count is greater than 500/mm3. The total duration of therapy depends on the nature and severity of the infection.

Usual Adult Dose for Joint Infection:

2 g IV every 8 hours

Therapy should be continued for approximately 3 to 4 weeks, depending on the nature and severity of the infection. Longer therapy, 6 weeks or more, may be required for prosthetic joint infections.

Usual Adult Dose for Intraabdominal Infection:

2 g IV every 8 hours for 7 to 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Melioidosis:

2 g IV every 8 hours

Parenteral therapy should be continued for at least 10 days, followed by doxycycline 100 mg orally twice daily plus chloramphenicol 10 mg/kg orally (not available in the United States) four times daily plus sulfamethoxazole-trimethoprim 25 mg/kg - 5 mg/kg orally twice a day. Doxycycline and sulfamethoxazole-trimethoprim should be continued for 20 weeks; chloramphenicol for the first 8 weeks.

Usual Adult Dose for Nosocomial Pneumonia:

2 g IV every 8 hours

Initial empiric treatment with broad-spectrum coverage according to the hospital's and/or ICU's antibiogram is recommended if multidrug-resistant organisms are suspected.

Duration: If the causative organism is not Pseudomonas aeruginosa, the duration of treatment should be as short as clinically possible (e.g., as little as 7 days) to reduce the risk of superinfections with resistant organisms.

Usual Adult Dose for Osteomyelitis:

2 g IV every 8 hours

Therapy should be continued for approximately 4 to 6 weeks, depending on the nature and severity of the infection. Chronic osteomyelitis may require an additional 1 to 2 months of oral antibiotics. Surgical debridement may be helpful.

Usual Adult Dose for Otitis Externa:

Malignant (necrotizing) otitis externa: 2 g IV every 8 hours

Therapy may be required for 2 to 6 weeks, depending on the nature and severity of the infection.

Usual Adult Dose for Otitis Media:

Otitis media in hospitalized intubated patients: 2 g IV every 8 hours

Usual Adult Dose for Pelvic Inflammatory Disease:

2 g IV or IM every 8 hours

Therapy should be continued for at least 48 hours after clinical improvement is demonstrated. Oral therapy should then be continued to complete a 14 day course of treatment.

Usual Adult Dose for Peritonitis:

1 to 2 g IV every 8 hours for 10 to 14 days, depending on the nature and severity of the infection

Peritoneal dialysis patients (ceftazidime sodium):
Intermittent: 1 g/2 L dialysate intraperitoneally once daily
Continuous: 1 g /2 L dialysate intraperitoneally, followed by 250 to 500 mg/2 L dialysate

Usual Adult Dose for Pneumonia:

1 to 2 g IV or IM every 8 hours

Therapy should be continued for 7 to 21 days, depending on the nature and severity of the infection.

Usual Adult Dose for Pneumonia with Cystic Fibrosis:

Lung infections caused by Pseudomonas: 30 to 50 mg/kg IV every 8 hours to a maximum of 6 g/day, in patients with normal renal function

Usual Adult Dose for Pyelonephritis:

1 to 2 g IV or IM every 8 hours for approximately 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Sinusitis:

Sinusitis in intubated patients: 2 g IV every 8 hours for 10 to 14 days, depending on the nature and severity of the infection

Usual Adult Dose for Skin or Soft Tissue Infection:

1 to 2 g IV or IM every 8 hours

Therapy should be continued for approximately 7 to 10 days, or for 3 days after the acute inflammation disappears, depending on the nature and severity of the infection. For more severe infections, such as diabetic soft tissue infections, 14 to 21 days of therapy may be required.

Vibrio vulnificus: 1 to 2 g IV every 8 hours plus doxycycline 100 mg IV or orally every 12 hours or ciprofloxacin 400 mg IV every 12 hours.

Usual Adult Dose for Cystitis:

Uncomplicated: 250 mg IV or IM every 12 hours for approximately 3 to 7 days, depending on the nature and severity of the infection

Complicated: 500 mg IV or IM every 8 to 12 hours for 2 to 3 weeks, depending on the nature and severity of the infection

Parenteral therapy is generally not indicated for uncomplicated infections.

Usual Adult Dose for Urinary Tract Infection:

Uncomplicated: 250 mg IV or IM every 12 hours for approximately 3 to 7 days, depending on the nature and severity of the infection

Complicated: 500 mg IV or IM every 8 to 12 hours for 2 to 3 weeks, depending on the nature and severity of the infection

Parenteral therapy is generally not indicated for uncomplicated infections.

Usual Pediatric Dose for Bacteremia:

0 to 4 weeks, birthweight 1199 g or less: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 1200 to 2000 g: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 2001 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
7 days to 4 weeks, birthweight 1200 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
1 month to 12 years: 30 to 50 mg/kg IV every 8 hours; maximum dose is 6 g/day
13 years or older: Adult dosage

The higher dose range should be reserved for patients with meningitis, cystic fibrosis, or immunocompromised patients.

Usual Pediatric Dose for Cystitis:

0 to 4 weeks, birthweight 1199 g or less: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 1200 to 2000 g: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 2001 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
7 days to 4 weeks, birthweight 1200 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
1 month to 12 years: 30 to 50 mg/kg IV every 8 hours; maximum dose is 6 g/day
13 years or older: Adult dosage

The higher dose range should be reserved for patients with meningitis, cystic fibrosis, or immunocompromised patients.

Usual Pediatric Dose for Intraabdominal Infection:

0 to 4 weeks, birthweight 1199 g or less: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 1200 to 2000 g: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 2001 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
7 days to 4 weeks, birthweight 1200 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
1 month to 12 years: 30 to 50 mg/kg IV every 8 hours; maximum dose is 6 g/day
13 years or older: Adult dosage

The higher dose range should be reserved for patients with meningitis, cystic fibrosis, or immunocompromised patients.

Usual Pediatric Dose for Joint Infection:

0 to 4 weeks, birthweight 1199 g or less: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 1200 to 2000 g: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 2001 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
7 days to 4 weeks, birthweight 1200 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
1 month to 12 years: 30 to 50 mg/kg IV every 8 hours; maximum dose is 6 g/day
13 years or older: Adult dosage

The higher dose range should be reserved for patients with meningitis, cystic fibrosis, or immunocompromised patients.

Usual Pediatric Dose for Meningitis:

0 to 4 weeks, birthweight 1199 g or less: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 1200 to 2000 g: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 2001 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
7 days to 4 weeks, birthweight 1200 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
1 month to 12 years: 30 to 50 mg/kg IV every 8 hours; maximum dose is 6 g/day
13 years or older: Adult dosage

The higher dose range should be reserved for patients with meningitis, cystic fibrosis, or immunocompromised patients.

Usual Pediatric Dose for Osteomyelitis:

0 to 4 weeks, birthweight 1199 g or less: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 1200 to 2000 g: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 2001 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
7 days to 4 weeks, birthweight 1200 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
1 month to 12 years: 30 to 50 mg/kg IV every 8 hours; maximum dose is 6 g/day
13 years or older: Adult dosage

The higher dose range should be reserved for patients with meningitis, cystic fibrosis, or immunocompromised patients.

Usual Pediatric Dose for Peritonitis:

0 to 4 weeks, birthweight 1199 g or less: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 1200 to 2000 g: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 2001 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
7 days to 4 weeks, birthweight 1200 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
1 month to 12 years: 30 to 50 mg/kg IV every 8 hours; maximum dose is 6 g/day
13 years or older: Adult dosage

The higher dose range should be reserved for patients with meningitis, cystic fibrosis, or immunocompromised patients.

Usual Pediatric Dose for Pneumonia:

0 to 4 weeks, birthweight 1199 g or less: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 1200 to 2000 g: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 2001 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
7 days to 4 weeks, birthweight 1200 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
1 month to 12 years: 30 to 50 mg/kg IV every 8 hours; maximum dose is 6 g/day
13 years or older: Adult dosage

The higher dose range should be reserved for patients with meningitis, cystic fibrosis, or immunocompromised patients.

Usual Pediatric Dose for Pneumonia with Cystic Fibrosis:

0 to 4 weeks, birthweight 1199 g or less: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 1200 to 2000 g: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 2001 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
7 days to 4 weeks, birthweight 1200 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
1 month to 12 years: 30 to 50 mg/kg IV every 8 hours; maximum dose is 6 g/day
13 years or older: Adult dosage

The higher dose range should be reserved for patients with meningitis, cystic fibrosis, or immunocompromised patients.

Usual Pediatric Dose for Pyelonephritis:

0 to 4 weeks, birthweight 1199 g or less: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 1200 to 2000 g: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 2001 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
7 days to 4 weeks, birthweight 1200 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
1 month to 12 years: 30 to 50 mg/kg IV every 8 hours; maximum dose is 6 g/day
13 years or older: Adult dosage

The higher dose range should be reserved for patients with meningitis, cystic fibrosis, or immunocompromised patients.

Usual Pediatric Dose for Septicemia:

0 to 4 weeks, birthweight 1199 g or less: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 1200 to 2000 g: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 2001 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
7 days to 4 weeks, birthweight 1200 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
1 month to 12 years: 30 to 50 mg/kg IV every 8 hours; maximum dose is 6 g/day
13 years or older: Adult dosage

The higher dose range should be reserved for patients with meningitis, cystic fibrosis, or immunocompromised patients.

Usual Pediatric Dose for Urinary Tract Infection:

0 to 4 weeks, birthweight 1199 g or less: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 1200 to 2000 g: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 2001 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
7 days to 4 weeks, birthweight 1200 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
1 month to 12 years: 30 to 50 mg/kg IV every 8 hours; maximum dose is 6 g/day
13 years or older: Adult dosage

The higher dose range should be reserved for patients with meningitis, cystic fibrosis, or immunocompromised patients.

Usual Pediatric Dose for Skin and Structure Infection:

0 to 4 weeks, birthweight 1199 g or less: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 1200 to 2000 g: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 2001 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
7 days to 4 weeks, birthweight 1200 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
1 month to 12 years: 30 to 50 mg/kg IV every 8 hours; maximum dose is 6 g/day
13 years or older: Adult dosage

The higher dose range should be reserved for patients with meningitis, cystic fibrosis, or immunocompromised patients.

Usual Pediatric Dose for Nosocomial Pneumonia:

0 to 4 weeks, birthweight 1199 g or less: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 1200 to 2000 g: 30 to 50 mg/kg IV every 12 hours
0 to 7 days, birthweight 2001 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
7 days to 4 weeks, birthweight 1200 g or more: 30 to 50 mg/kg IV every 8 to 12 hours
1 month to 12 years: 30 to 50 mg/kg IV every 8 hours; maximum dose is 6 g/day
13 years or older: Adult dosage

The higher dose range should be reserved for patients with meningitis, cystic fibrosis, or immunocompromised patients.

What other drugs will affect ceftazidime injection?

Tell your doctor about all other medicines you use, especially:

  • chloramphenicol (Chloromycetin);

  • diuretics (water pills) such as furosemide (Lasix); or

  • an antibiotic such as amikacin (Amikin), gentamicin (Garamycin), kanamycin (Kantrex), neomycin (Mycifradin, Neo-Fradin, Neo-Tab), streptomycin, or tobramycin (Nebcin, Tobi).

This list is not complete and other drugs may interact with ceftazidime. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your doctor or pharmacist can provide more information about ceftazidime injection.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 5.01. Revision Date: 2011-09-26, 3:43:08 PM.

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