Ceftazidime Side Effects
Some side effects of ceftazidime may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
For the Consumer
Applies to ceftazidime: injection powder for solution
Along with its needed effects, ceftazidime may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur while taking ceftazidime:Less common
- Abdominal or stomach cramps or tenderness
- bluish color
- changes in skin color
- diarrhea, watery and severe, which may also be bloody
- increased thirst
- itching of the vagina or genital area
- nausea or vomiting
- pain during sexual intercourse
- swelling at the site of injection
- swelling of the foot or leg
- thick, white vaginal discharge with no odor or with a mild odor
- unusual tiredness or weakness
- unusual weight loss
- white patches in the mouth or throat or on the tongue
- white patches with diaper rash
- Back, leg, or stomach pains
- bleeding gums
- burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
- dark urine
- difficulty with breathing
- difficulty with swallowing
- fast heartbeat
- general body swelling
- large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
- loss of appetite
- pale skin
- puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
- shortness of breath
- skin rash
- sore throat
- tightness in the chest
- yellowing of the eyes or skin
- bloody or cloudy urine
- blurred vision
- change in consciousness
- chest pain
- clay-colored stools
- coughing up blood
- decreased frequency or amount of urine
- difficult or painful urination
- increased blood pressure
- increased menstrual flow or vaginal bleeding
- increased thirst
- loss of consciousness
- lower back or side pain
- muscle twitching or jerking
- prolonged bleeding from cuts
- red or black, tarry stools
- red or dark brown urine
- rhythmic movement of the muscles
- sores, ulcers, or white spots on the lips or in the mouth
- stiff neck
- sudden decrease in the amount of urine
- swelling of the face, fingers, or lower legs
- swollen or painful glands
- troubled breathing
- unpleasant breath odor
- unusual bleeding or bruising
- vomiting of blood
- watery or bloody diarrhea
- weight gain
Some side effects of ceftazidime may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:More common
- Red streaks on the skin
- swelling, tenderness, or pain at the injection site
For Healthcare Professionals
Applies to ceftazidime: injectable powder for injection, intravenous solution
Gastrointestinal side effects reported in less than 2% of patients have included diarrhea, nausea, vomiting, abdominal pain, and pseudomembranous colitis. Oral candidiasis has been reported in less than 1% of patients. Clostridium difficile associated diarrhea has also been reported.
Discontinuation of ceftazidime may be necessary in severe, prolonged cases of diarrhea. Pseudomembranous colitis has been reported and should be considered if the patient does not respond to discontinuation of ceftazidime.
Mild hypersensitivity reactions, such as rash, pruritus, and fever, have been reported and may necessitate discontinuation of ceftazidime. A case of asthma induced by occupational exposure to ceftazidime has been reported.
A case of occupational contact dermatitis due to cephalosporin allergy has been reported in a nurse who prepared cephalosporin solutions for administration to patients. The dermatitis resolved after the nurse stopped preparing the solutions.
A patient with sensitization to aztreonam showed cross-reactivity to ceftazidime. Ceftazidime and aztreonam contain the same side chain, which may explain the cross-sensitivity.
Hypersensitivity reactions including rash, pruritus, and fever have been reported (2%). Cross reactions may occur in penicillin-allergic or aztreonam-allergic patients. Rarely, angioedema and anaphylactic reactions have occurred. Allergic reactions including cardiopulmonary arrest have been reported during postmarketing experience. Cephalosporin class antibiotics have been associated with Stevens-Johnson syndrome, erythema multiforme, and toxic epidermal necrolysis.
Although increases in serum creatinine do not necessarily indicate renal toxicity, urinary alanine aminopeptidase (AAP) has been found to be significantly increased in some patients and may indicate renal tubular cell damage.
Renal side effects have included transient increases in serum creatinine and BUN. Renal impairment has been reported during postmarketing experience. Cephalosporins as a class have been associated with renal dysfunction and toxic nephropathy.
Ceftazidime-induced encephalopathy has been reported in an 80-year-old man with underlying renal dysfunction. This patient became incoherent and tremulous and had severe myoclonic jerking in all extremities. Therapy was discontinued and symptoms abated, but reappeared on rechallenge with a smaller dose. Symptoms again resolved with discontinuation of ceftazidime therapy. Several other cases of ceftazidime-induced encephalopathy, and hallucinations have been reported. In most cases the patients had underlying renal dysfunction. Symptoms were similar and resolved with dose reduction or drug discontinuation.
Neurologic reactions may be more likely to occur in patients with underlying renal dysfunction. Close monitoring of neurologic status is recommended.
Nervous system side effects reported in less than 1% of patients have included headache, dizziness, paresthesia, and seizures. Encephalopathy, coma, asterixis, neuromuscular excitability, and myoclonia have occurred in patients with renal dysfunction who received unadjusted doses of ceftazidime.
Dermatologic side effects have included pemphigus erythematosus and urticaria.
Local side effects have included phlebitis and inflammation at the injection site.
Hematologic side effects have included transient eosinophilia, positive Coombs test without hemolysis, thrombocytosis, leukopenia, neutropenia, agranulocytosis, thrombocytopenia, and lymphocytosis. Cephalosporins as a class have been associated with aplastic anemia, hemolytic anemia, prolonged prothrombin time, hemorrhage, neutropenia, pancytopenia, and agranulocytosis.
Other transient hematologic effects, such as thrombocytopenia, thrombocytosis, and leukopenia, have been observed less frequently.
Hepatic side effects have included transient increases in AST, ALT, GGT, and alkaline phosphatase. These elevations generally resolve after discontinuation of therapy. Hyperbilirubinemia and jaundice have been reported during postmarketing experience. Cephalosporins as a class have been associated with hepatic dysfunction, including cholestasis.
Genitourinary side effects have included vaginitis and candidiasis. Cephalosporins as a class have been associated with false-positive tests for urine glucose.
Other side effects have included superinfection.
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