Ceftazidime use while Breastfeeding

Drugs containing Ceftazidime: Fortaz, Tazicef, Tazidime, Ceptaz, Tazicef Novaplus

Ceftazidime Levels and Effects while Breastfeeding

Summary of Use during Lactation

Ceftazidime is acceptable to use during breastfeeding. Limited information indicates that single maternal doses of ceftazidime up to 2 grams produce low levels in milk that are not expected to cause adverse effects in breastfed infants. Occasionally, disruption of the infant's gastrointestinal flora, resulting in diarrhea or thrush, has been reported with cephalosporins, but these effects have not been adequately evaluated.

Drug Levels

Maternal Levels. Ceftazidime 2 grams was given to 11 women intravenously every 8 hours for 5 days. The average trough milk level was 3.8 mg/L before the next dose, 5.2 mg/L 1 hour after the dose and 4.5 mg/L 3 hours after the dose. These differences were not statistically significant. The average drug concentrations in milk were 3.9 mg/L for samples before the seventh dose and 4.9 mg/L in milk samples after the seventh dose, but this difference was not statistically significant. There was no correlation between the mother's weight and the ceftazidime milk levels.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

References

1. Blanco JD, Jorgensen JH, Castaneda YS et al. Ceftazidime levels in human breast milk. Antimicrob Agents Chemother. 1983;23:479-80. PMID: 6342531

Ceftazidime Identification

Substance Name

Ceftazidime

CAS Registry Number

78439-06-2

Drug Class

Administrative Information

LactMed Record Number

54

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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