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Adenocard Side Effects

Generic Name: adenosine

Note: This page contains information about the side effects of adenosine. Some of the dosage forms included on this document may not apply to the brand name Adenocard.

Not all side effects for Adenocard may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to adenosine: intravenous solution

In addition to its needed effects, some unwanted effects may be caused by adenosine (the active ingredient contained in Adenocard). In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking adenosine, check with your doctor or nurse immediately:

More common
  • Chest discomfort
  • difficult or labored breathing
  • lightheadedness or dizziness
  • throat, neck, or jaw discomfort
  • tightness in the chest
Less common
  • Chest pain
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast, slow, or irregular heartbeat
  • sweating
  • troubled breathing
  • unusual tiredness or weakness
Rare
  • Fast, irregular, pounding, or racing heartbeat or pulse
  • headache
  • nervousness
  • pounding in the ears

Some of the side effects that can occur with adenosine may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common
  • Diarrhea
  • feeling of warmth
  • indigestion
  • loss of appetite
  • nausea or vomiting
  • passing of gas
  • redness of the face, neck, arms, and occasionally, upper chest
  • stomach pain, fullness, or discomfort
Rare
  • Area of decreased vision
  • cough
  • discomfort in the back, ears, or tongue
  • drowsiness
  • dry mouth
  • metallic taste
  • mood changes
  • shakiness in the legs, arms, hands, or feet
  • stuffy nose
  • trembling or shaking of the hands or feet

For Healthcare Professionals

Applies to adenosine: compounding powder, intravenous solution, sublingual spray

General

The most common adverse reactions are flushing, chest discomfort, dyspnea, facial flushing, headache, throat/neck/jaw discomfort, gastrointestinal discomfort, and lightheadedness/dizziness.[Ref]

Cardiovascular

Very common (10% or more): Flushing (44%), facial flushing (18%)
Common (1% to 10%): First degree atrioventricular block, second degree atrioventricular block, hypotension, arrhythmias, ventricular tachycardia
Uncommon (0.1% to 1%): Bradycardia, sinus tachycardia, palpitations
Very rare (less than 0.01%): Atrial fibrillation, ventricular fibrillation, Torsade de pointes, severe bradycardia
Frequency not reported: Myocardial infarction, ventricular arrhythmia, third degree atrioventricular block, sinus exit block, sinus pause, hypertension, skipped beats, atrial extrasystoles, ventricular extrasystoles
Postmarketing reports: Cardiac arrest/asystole, cardiac failure, tachycardia, prolonged asystole, transient increase in blood pressure[Ref]

Other

Very common (10% or more): Chest discomfort (40%)
Common (1% to 10%): ST segment depression, chest pressure
Uncommon (0.1% to 1%): Feeling of general discomfort/weakness/pain
Rare (less than 0.1%): Tinnitus, nipple discomfort
Frequency not reported: Chest pain, feeling of thoracic constriction/oppression, weakness, T wave changes, ear discomfort, tongue discomfort, heaviness in arms, pressure in groin
Postmarketing reports: ST segment elevation[Ref]

Respiratory

Very common (10% or more): Dyspnea (up to 28%)
Uncommon (0.1% to 1%): Hyperventilation
Rare (0.01% to 0.1%): Bronchospasm, nasal congestion
Very rare (less than 0.01%): Respiratory failure
Frequency not reported: Cough, throat tightness
Postmarketing reports: Respiratory arrest/apnea[Ref]

Nervous system

Very common (10% or more): Headache (up to 18%), lightheadedness/dizziness (12%)
Common (1% to 10%): Paresthesia, tingling in arms, numbness, burning sensation
Uncommon (0.1% to 1%): Metallic taste, head pressure
Rare (0.01% to 0.1%): Tremor, drowsiness
Very rare (less than 0.01%): Intracranial hypertension worsening
Frequency not reported: Scotomas, convulsions
Postmarketing reports: Cerebrovascular accident, intracranial hemorrhage, seizure, tonic clonic seizures, loss of consciousness/syncope[Ref]

Musculoskeletal

Very common (10% or more): Throat/neck/jaw discomfort (15%)
Common (1% to 10%): Upper extremity discomfort
Frequency not reported: Back discomfort, lower extremity discomfort, neck and back pain[Ref]

Gastrointestinal

Very common (10% or more): Gastrointestinal discomfort (13%)
Common (1% to 10%): Dry mouth, nausea
Frequency not reported: Abdominal discomfort
Postmarketing reports: Vomiting[Ref]

Psychiatric

Common (1% to 10%): Nervousness, apprehension
Frequency not reported: Emotional instability[Ref]

Dermatologic

Uncommon (0.1% to 1%): Sweating
Postmarketing reports: Angioedema, urticaria, rash[Ref]

Ocular

Uncommon (0.1% to 1%): Blurred vision[Ref]

Genitourinary

Rare (less than 0.1%): Urinary urgency
Frequency not reported: Vaginal pressure[Ref]

Local

Very rare (less than 0.01%): Injection site reaction
Postmarketing reports: Infusion site pain[Ref]

Hypersensitivity

Postmarketing reports: Hypersensitivity, anaphylaxis[Ref]

References

1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

2. Cerner Multum, Inc. "Australian Product Information." O 0

3. "Product Information. Prograf (tacrolimus)." Fujisawa, Deerfield, IL.

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