Acular Side Effects
Generic Name: ketorolac ophthalmic
Note: This page contains information about the side effects of ketorolac ophthalmic. Some of the dosage forms included on this document may not apply to the brand name Acular.
Not all side effects for Acular may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to ketorolac ophthalmic: ophthalmic solution
In addition to its needed effects, some unwanted effects may be caused by ketorolac ophthalmic (the active ingredient contained in Acular). In the event that any of these side effects do occur, they may require medical attention.
You should check with your doctor immediately if any of these side effects occur when taking ketorolac ophthalmic:More common
- Itching, redness, tearing, or other sign of eye irritation not present before use of this medicine or becoming worse during use
- redness of the clear part of the eye
- sensitivity to light
- swelling of the eye
- throbbing pain
- Blurred vision or other change in vision
- eye irritation or redness
Some of the side effects that can occur with ketorolac ophthalmic may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:More common
- Stinging or burning of the eye when medicine is applied
- Dry eyes
For Healthcare Professionals
Applies to ketorolac ophthalmic: ophthalmic solution
Ocular side effects have included transient burning and stinging upon instillation in 20% to 40% of patients. Conjunctival hyperemia, corneal infiltrates, and ocular edema have been reported in 1% to 5% of patients. Corneal edema, iritis, ocular inflammation, ocular irritation, ocular pain, superficial keratitis, and superficial ocular infections have been reported in 1% to 10% of patients. Corneal erosion, corneal thinning, and epithelial breakdown have also been reported.[Ref]
A 44-year-old female with a history of severe asthma was given ophthalmic ketorolac for the treatment of conjunctivitis previously unresponsive to topical antihistamine treatment. Two hours after instillation, she developed coughing and tightness in her chest which worsened over night. The next morning the patient was hospitalized with complaints of coughing, dyspnea at rest and wheezing. Her condition improved after administration of intravenous steroids and albuterol nebulizations.[Ref]
Hypersensitivity reactions have been reported in 1% to 10% of patients.[Ref]
1. Ostrov CS, Sirkin SR, Deutsch WE, Masi RJ, Chandler JW, Lindquist TD "Ketorolac, prednisolone, and dexamethasone for postoperative inflammation." Clin Ther 19 (1997): 259-72
2. "Product Information. Acular (ketorolac)." Allergan Inc, Irvine, CA.
3. Flach AJ, Jampol LM, Weinberg D, Kraff MC, Yannuzzi LA, Campo RV, Neumann AC, Cupples HP, Lefler WH, Pulido JS, et al "Improvement in visual acuity in chronic aphakic and pseudophakic cystoid macular edema after treatment with topical 0.5% ketorolac tromethamine." Am J Ophthalmol 112 (1991): 514-9
4. Fraser-Smith EB, Matthews TR "Effect of ketorolac on herpes simplex virus type one ocular infection in rabbits." J Ocul Pharmacol 4 (1988): 321-6
5. "Product Information. Acular LS (ketorolac ophthalmic)." Allergan Inc, Irvine, CA.
6. Rooks WH 2d, Maloney PJ, Shott LD, Schuler ME, Sevelius H, Strosberg AM, Tanenbaum L, Tomolonis AJ, Wallach MB, Waterbury D, et al "The analgesic and anti-inflammatory profile of ketorolac and its tromethamine salt." Drugs Exp Clin Res 11 (1985): 479-92
7. Fraser-Smith EB, Matthews TR "Effect of ketorolac on Pseudomonas aeruginosa ocular infection in rabbits." J Ocul Pharmacol 4 (1988): 101-9
8. Sitenga GL, Ing EB, Vandellen RG, Younge BR, Leavitt JA "Asthma caused by topical application of ketorolac." Ophthalmology 103 (1996): 890-2
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