aspirin and oxycodone

Generic Name: aspirin and oxycodone (AS pir in and ox i KOE done)
Brand Name: Endodan, Percodan, Percodan-Demi, Roxiprin

What is aspirin and oxycodone?

Aspirin is in a group of drugs called salicylates (sa-LIS-il-ates). It works by reducing substances in the body that cause pain, fever, and inflammation.

Oxycodone is an opioid pain medication. An opioid is sometimes called a narcotic.

Aspirin and oxycodone is a combination medicine used to relieve moderate to severe pain.

Aspirin and oxycodone may also be used for purposes not listed in this medication guide.

What is the most important information I should know about aspirin and oxycodone?

Oxycodone can slow or stop your breathing. Never use this medicine in larger amounts, or for longer than prescribed. Oxycodone may also be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

Slideshow: View Frightful (But Dead Serious) Drug Side Effects

MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription.

What should I discuss with my healthcare provider before taking aspirin and oxycodone?

You should not take this medication if you are allergic to aspirin or oxycodone, or if you have:

  • a bleeding or blood clotting disorder such as hemophilia;

  • ulcer or obstruction in the stomach;

  • severe asthma or breathing problems;

  • an allergy to an NSAID (nonsteroidal anti-inflammatory drug) such as Advil, Aleve, Motrin, Naprosyn, Orudis, Cataflam, Celecoxib, Feldene, Indocin, Lodine, Mobic, Relafen, Toradol, Voltaren, and others; or

  • if you are taking a blood thinner such as warfarin (Coumadin, Jantoven).

Do not use aspirin and oxycodone if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, rasagiline, selegiline, tranylcypromine, and others.

Do not give this medication to a child or teenager with a fever, flu symptoms, or chicken pox. Aspirin can cause Reye's syndrome, a serious and sometimes fatal condition in children.

To make sure aspirin and oxycodone is safe for you, tell your doctor if you have:

  • stomach or intestinal disorder, history of stomach ulcer or bleeding;

  • a blockage in your stomach or intestines;

  • any type of breathing problem or lung disease;

  • allergies, nasal polyps;

  • urination problems;

  • liver or kidney disease;

  • a history of head injury, brain tumor, or seizures;

  • a history of drug abuse, alcohol addiction, or mental illness; or

  • problems with your gallbladder, pancreas, or thyroid.

This medicine is more likely to cause breathing problems in older adults and people who are severely ill, malnourished, or otherwise debilitated.

FDA pregnancy category D. Do not use this medicine if you are pregnant. Use effective birth control to prevent pregnancy while taking aspirin and oxycodone.

  • Oxycodone may cause breathing problems, behavior changes, or life-threatening addiction and withdrawal symptoms in your newborn if you use the medication during pregnancy.

  • Taking aspirin during late pregnancy may cause bleeding in the mother or the baby during delivery.

Aspirin and oxycodone can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using aspirin and oxycodone.

How should I take aspirin and oxycodone?

Follow all directions on your prescription label. Oxycodone can slow or stop your breathing. Never use aspirin and oxycodone in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in relieving your pain.

Oxycodone may be habit-forming, even at regular doses. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. MISUSE OF NARCOTIC MEDICINE CAN CAUSE ADDICTION, OVERDOSE, OR DEATH, especially in a child or other person using the medicine without a prescription. Selling or giving away aspirin and oxycodone is against the law.

Always check your bottle to make sure you have received the correct pills (same brand and type) of medicine prescribed by your doctor. Ask the pharmacist if you have any questions about the medicine you receive at the pharmacy.

Aspirin and oxycodone may be taken with food if it upsets your stomach.

If you need surgery, tell the surgeon ahead of time that you are using aspirin and oxycodone. You may need to stop using the medicine for a short time.

Do not stop using aspirin and oxycodone suddenly after long-term use, or you could have unpleasant withdrawal symptoms. Ask your doctor how to avoid withdrawal symptoms when you stop using aspirin and oxycodone.

Store at room temperature away from moisture, heat, and light.

Keep track of the amount of medicine used from each new bottle. Oxycodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

After you have stopped using this medication, flush any unused pills down the toilet. Disposal of medicines by flushing is recommended to reduce the danger of accidental overdose causing death. This advice applies to a very small number of medicines only. The FDA, working with the manufacturer, has determined this method to be the most appropriate route of disposal and presents the least risk to human safety.

What happens if I miss a dose?

Since aspirin and oxycodone is used for pain, you are not likely to miss a dose. Skip any missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A aspirin and oxycodone overdose can be fatal, especially in a child or other person using the medicine without a prescription. Overdose symptoms may include slow breathing and heart rate, severe drowsiness, muscle weakness, cold and clammy skin, pinpoint pupils, and fainting.

What should I avoid while taking aspirin and oxycodone?

Avoid drinking alcohol. It may increase your risk of stomach bleeding while taking aspirin.

This medication may impair your thinking or reactions. Avoid driving or operating machinery until you know how aspirin and oxycodone will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Ask a doctor or pharmacist before using any other over-the-counter cold, allergy, or pain medicine. Aspirin is contained in many combination medicines. Taking certain products together can cause you to get too much aspirin. Check the label to see if a medicine contains aspirin.

Ask your doctor before using aspirin and oxycodone if you take an antidepressant such as citalopram, escitalopram, fluoxetine (Prozac), fluvoxamine, paroxetine, sertraline (Zoloft), trazodone, or vilazodone. Taking any of these medicines with an NSAID may cause you to bruise or bleed easily.

Aspirin and oxycodone side effects

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • severe stomach pain or constipation, vomiting;

  • easy bruising, unusual bleeding, bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds;

  • weak or shallow breathing, fast or slow heartbeat;

  • confusion, hallucinations, unusual thoughts or behavior, feeling like you might pass out;

  • seizure (convulsions); or

  • decreased hearing or ringing in the ears.

Common side effects may include:

  • headache, dizziness, drowsiness;

  • constipation, heartburn, upset stomach, bloating, gas, diarrhea; or

  • dry mouth.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Aspirin and oxycodone dosing information

Usual Adult Dose for Pain:

For the relief of moderate to moderately severe pain:
1 tablet (aspirin 325 mg/oxycodone 4.5-0.38 mg or aspirin 325 mg/oxycodone 4.8355 mg) or
1 to 2 tablets (aspirin 325 mg/oxycodone 2.25-0.198 mg) orally every 6 hours.

Usual Pediatric Dose for Pain:

5 years or younger: Use is not indicated.

6 to 12 years: One-fourth of an aspirin-oxycodone 325 mg-2.25 mg-0.19 mg tablet every six hours.

12 years or older: One-half of an aspirin-oxycodone 325 mg-2.25 mg-0.19 mg tablet every six hours.

What other drugs will affect aspirin and oxycodone?

Taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking aspirin and oxycodone with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with aspirin and oxycodone, especially:

  • medication to prevent blood clots--dalteparin, desirudin, enoxaparin, fondaparinux, tinzaparin, warfarin, Coumadin; or

  • an NSAID (nonsteroidal anti-inflammatory drug)--ibuprofen (Advil, Motrin), ketorolac.

This list is not complete. Other drugs may interact with aspirin and oxycodone, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about aspirin and oxycodone.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2012 Cerner Multum, Inc. Version: 9.02. Revision Date: 2014-04-13, 7:54:59 PM.

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