Aspirin/oxycodone Pregnancy and Breast Feeding Warnings
Aspirin/oxycodone is also known as: Endodan, Percodan, Percodan-Demi, Roxiprin
Overview
Aspirin/Oxycodone has been shown to cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using Aspirin/Oxycodone while you are pregnant. Avoid using Aspirin/Oxycodone during the last 3 months of pregnancy. Aspirin/Oxycodone is found in breast milk. Do not breast-feed while taking Aspirin/Oxycodone .
Aspirin/oxycodone Pregnancy Warnings
Aspirin-oxycodone has not been formally assigned to pregnancy category by the FDA. Use of aspirin in pregnancy has been associated with alterations in both maternal and fetal hemostasis. In addition, high doses have been associated with increased perinatal mortality, intrauterine growth retardation, and teratogenic effects. Use of narcotic analgesics in late pregnancy has been associated with the risk of neonatal withdrawal. There are no controlled data in human pregnancy. Aspirin-oxycodone should only be given during pregnancy when there are no alternatives and benefit outweighs risk. In 1990, the FDA issued a warning that it is especially important not to use aspirin during the last trimester of pregnancy unless specifically directed to do so by a physician because it may cause problems in the unborn child or complications during delivery.
A study of low-dose aspirin (follow-up from the Italian Study of Aspirin in Pregnancy) has suggested that "low dose aspirin in pregnancy is safe with respect to the risks of malformation and of major impairment in development at 18 months of age." High-dose aspirin (2 g per day) has been associated with stillbirths, cerebral hemorrhage, oculoauriculovertebral dysplasia, neonatal salicylate toxicity, constricted ductus arteriosus, cyclopia, and neonatal acidosis. Some cases of congenital heart defects have been reported. However, a case control study of aspirin use in the first trimester concluded that aspirin "does not increase the risk of congenital heart defects in relation to that of other structural malformations."
Aspirin/oxycodone Lactation Warnings
Aspirin is excreted into human milk in small amounts. Peak milk salicylate levels have been reported at nine hours after maternal dosing (and measured at 1.1 mg/dl). Because of a single case report of metabolic acidosis, the American Academy of Pediatric characterizes aspirin as a drug that has been "associated with significant effects on some nursing infants and should be given to nursing mothers with caution". Oxycodone is excreted into human milk, but the clinical significance is unknown.
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