Aspirin / oxycodone Pregnancy and Breastfeeding Warnings
Aspirin / oxycodone Pregnancy Warnings
Aspirin-oxycodone has not been formally assigned to pregnancy category by the FDA. Aspirin has been assigned to pregnancy category D by the FDA and oxycodone has been assigned to pregnancy category B by the FDA. Salicylates readily cross the placenta and inhibit prostaglandin synthesis, which may cause constriction of ductus arteriosus resulting in pulmonary hypertension and increased fetal mortality. Use of aspirin in pregnancy has been associated with alterations in both maternal and fetal hemostasis. Maternal aspirin use during later stages of pregnancy may cause low birth weight, increased incidence of intracranial hemorrhage in premature infants, stillbirths, and neonatal death. Use of aspirin during pregnancy, especially in the third trimester, should be avoided. Use of narcotic analgesics in late pregnancy has been associated with the risk of neonatal withdrawal. There are no controlled data in human pregnancy. Aspirin-oxycodone should only be given during pregnancy only when there are no alternatives and benefit outweighs risk.
Aspirin / oxycodone Breastfeeding Warnings
Aspirin is excreted into human milk in small amounts. Peak milk salicylate levels have been reported at nine hours after maternal dosing (and measured at 1.1 mg/dl). Because of a single case report of metabolic acidosis, the American Academy of Pediatric characterizes aspirin as a drug that has been "associated with significant effects on some nursing infants and should be given to nursing mothers with caution". Oxycodone is excreted into human milk, but the clinical significance is unknown.
- aspirin/oxycodone Consumer Information
- Pregnancy Support Group
- FDA Pregnancy Categories
- Medicine use during Pregnancy
- Medicine use while Breastfeeding
- Safe Medications during Breastfeeding
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This drug information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information in contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.