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Amphetamine (Monograph)

Brand name: Adderall
Drug class: Amphetamines
VA class: CN801
CAS number: 60-13-9

Medically reviewed by Drugs.com on May 18, 2023. Written by ASHP.

Warning

FDA drug safety communication (5/11/2023):

To address continuing concerns of misuse, abuse, addiction, and overdose of prescription stimulants, FDA is requiring updates to the Boxed Warning and other information to ensure the prescribing information is consistent across the entire class of these drugs.

The current prescribing information in some prescription stimulants does not provide up to date warnings about the harms of misuse and abuse, particularly when these drugs are shared with individuals for whom they are not prescribed. An FDA review found that most individuals who misuse prescription stimulants obtain their drugs from family members or peers, and that such sharing of prescription stimulants was a major contributor to nonmedical use and addiction.

Updates will include information that patients should never share their prescription stimulants with anyone, and the Boxed Warning information will describe the risks of misuse, abuse, addiction, and overdose consistently across all medicines in the class. The Boxed Warning will also advise healthcare professionals to monitor patients closely for signs and symptoms of misuse, abuse, and addiction.

Warning

    Abuse Potential
  • Amphetamines have a high potential for abuse.

  • Administration of amphetamines for prolonged periods of time may lead to drug dependence.

  • Particular attention should be paid to the possibility of individuals obtaining amphetamines for nontherapeutic use or distribution to others, and the drugs should be prescribed or dispensed sparingly.

  • The possibility that family members may abuse the patient’s medication should be considered.

    Sudden Death and Serious Cardiovascular Events
  • Possible sudden death and serious cardiovascular events, particularly in individuals who abuse amphetamines. (See Sudden Death and Serious Cardiovascular Events under Cautions.)

Introduction

Noncatechol, sympathomimetic amine with CNS-stimulating activity.

Uses for Amphetamine

Attention Deficit Hyperactivity Disorder

Used as an adjunct to psychological, educational, social, and other remedial measures in the treatment of attention deficit hyperactivity disorder (ADHD) (hyperkinetic disorder, hyperkinetic syndrome of childhood, minimal brain dysfunction).

Can be used for ADHD in pediatric (children, adolescents) as well as adult patients.

Almost all studies comparing behavioral therapy versus stimulants alone have shown a much stronger therapeutic effect from stimulants than from behavioral therapy, and stimulants (e.g., amphetamines, methylphenidate) remain the drugs of choice for the management of ADHD.

Drug therapy is not indicated in all patients with ADHD, and such therapy should be considered only after a complete evaluation including medical history has been performed.

Use should depend on age, adequate diagnosis (based on medical, special psychological, educational, and social resources), and the clinician’s assessment of the severity and duration of symptoms and should not depend solely on one or more behavioral characteristics.

Not recommended for ADHD symptoms associated with acute stress reactions.

Narcolepsy

Used as a stimulant to reduce daytime sleepiness in the management of narcolepsy.

Amphetamines remain the mainstay of treatment for narcolepsy based on a long record of clinical experience.

Tolerance to the clinical effects may develop with long-term therapy, particularly at high dosages.

Exogenous Obesity

Has been used as an adjunct to caloric restriction and behavioral modification in the short-term treatment of exogenous obesity [off-label]. However, because of the limited efficacy (short-lived) and risk of abuse, such use no longer is included in the FDA-approved labeling and is discouraged.

The anorexigenic effect appears to be temporary, seldom lasting more than a few weeks, and tolerance may occur.

Obesity usually is a chronic disease, and short-term or intermittent therapy with anorexigenic drugs is unlikely to maintain a long-term benefit.

Amphetamine Dosage and Administration

Administration

Oral Administration

Conventional Tablets

Administer initial dose on awakening. When daily dosage is administered in 2 or 3 divided doses, administer the doses at intervals of 4–6 hours. Because of potential for insomnia, avoid administering doses in the late evening.

Extended-release Capsules

Administer on awakening. Because of potential for insomnia, avoid administering in the afternoon.

Administer capsules with or without food; capsules may be swallowed intact or the entire contents of a capsule(s) may be sprinkled on a small amount of applesauce immediately prior to administration. Do not subdivide the capsule contents. Do not chew or crush the pellets contained in the capsules and do not store the sprinkle/food mixture for later use.

Dosage

Fixed-combination extended-release capsules containing various salts of amphetamine and dextroamphetamine can be substituted for their respective conventional short-acting preparations if less-frequent daily dosing is desirable.

Dosage of fixed-combination preparations containing various salts of amphetamine and dextroamphetamine is expressed as total amphetamine base equivalence.

Adjust dosage according to individual response and tolerance; the smallest dose required to produce the desired response should always be used.

When possible, therapy should be interrupted occasionally to determine if there is a recurrence of behavioral symptoms sufficient to require continued treatment.

Pediatric Patients

Attention Deficit Hyperactivity Disorder

Dosage titration usually requires 2–4 weeks.

Conventional Tablets
Oral

Dosing in pediatric patients may begin with once-daily administration in the early morning, adding a noon dose if the effect does not last throughout the school day. Increasing the morning dose may extend its duration. A third dose may be added at around 4 p.m. if necessary.

Children 3–5 years of age: Initially, 2.5 mg daily; the daily dosage is increased in 2.5-mg increments at weekly intervals until the optimum response is attained.

Children ≥6 years of age: Initially, 5 mg once or twice daily; the daily dosage is increased in 5-mg increments at weekly intervals until the optimum response is attained. Total daily dosage rarely should exceed 40 mg.

Extended-release Capsules (Adderall XR)
Oral

Children 6–12 years of age: Initially, 10 mg once daily; daily dosage may be increased in 5- or 10-mg increments at weekly intervals to a maximum dosage of 30 mg daily. Alternatively, initiate with 5 mg once daily when lower initial dosage is appropriate.

Adolescents 13–17 years of age: Initially, 10 mg once daily. Increase to 20 mg once daily after 1 week if symptoms not adequately controlled. No evidence that dosages >20 mg daily provide any additional benefit.

When switching from conventional tablets to extended-release capsules, the total daily dosage may remain the same but may be given once daily.

Narcolepsy

When intolerable adverse effects occur (e.g., insomnia, anorexia), dosage should be reduced.

Conventional Tablets
Oral

Children 6–12 years of age: Initially, 5 mg daily; daily dosage is increased in 5-mg increments at weekly intervals until the optimum response is attained.

Children ≥12 years of age: Initially, 10 mg daily; daily dosage is increased in 10-mg increments at weekly intervals until the optimum response is attained.

Maintenance: Usually, 5–60 mg daily, depending on patient age and response, given in divided doses.

Adults

Attention Deficit Hyperactivity Disorder
Conventional Tablets

Dosage titration usually requires 2–4 weeks.

Oral

Initially, 5 mg once or twice daily; the daily dosage is increased in 5- to 10-mg increments at weekly intervals until the optimum response is attained. Total daily dosage rarely should exceed 40 mg.

Extended-release Capsules (Adderall XR)
Oral

20 mg once daily as initial therapy or when switching from other drugs. No evidence that dosages >20 mg daily provide any additional benefit.

When switching from conventional tablets to extended-release capsules, the total daily dosage may remain the same but may be given once daily.

Narcolepsy

When intolerable adverse effects occur (e.g., insomnia, anorexia), dosage should be reduced.

Conventional Tablets
Oral

Initially, 10 mg daily; daily dosage is increased in 10-mg increments at weekly intervals until the optimum response is attained.

Maintenance: Usually, 5–60 mg daily, depending on response, given in divided doses.

Prescribing Limits

Pediatric Patients

Attention Deficit Hyperactivity Disorder

Excessive dosage can cause pediatric patients to become overfocused on the medication or to appear dull or overly restricted. Rarely, psychotic reactions, mood disturbances, or hallucinations can occur.

Conventional Tablets
Oral

Dosage rarely should exceed a total daily dosage of 40 mg. Individual doses rarely should exceed 10 mg each in children <25 kg.

Long-term use has not been studied systematically. If used for long-term therapy, periodically reevaluate the usefulness of the drug.

Extended-release Capsules (Adderall XR)
Oral

Children 6–12 years of age: Dosages >30 mg daily have not been studied systematically.

Adolescents 13–17 years of age: Dosages up to 60 mg daily have been evaluated in clinical studies; however, no evidence that dosages >20 mg daily provide any additional benefit.

Long-term use (>3 weeks in children or >4 weeks in adolescents) has not been studied systematically. If used for long-term therapy, periodically reevaluate the usefulness of the drug.

Adults

Attention Deficit Hyperactivity Disorder
Conventional Tablets
Oral

Dosages up to 0.9 mg/kg daily but rarely exceeding 40 mg daily. Such higher doses may be more likely in adults than in school-aged children because of increased dosing frequency to cover a longer work day.

Tolerance is more likely with relatively high dosages.

Long-term use has not been studied systematically. If used for long-term therapy, periodically reevaluate the usefulness of the drug.

Extended-release Capsules (Adderall XR)
Oral

Dosages up to 60 mg daily have been evaluated in clinical studies; however, no evidence that dosages >20 mg daily provide any additional benefit.

Long-term use (>4 weeks) has not been studied systematically. If used for long-term therapy, periodically reevaluate the usefulness of the drug.

Special Populations

Hepatic Impairment

No specific hepatic dosage recommendations.

Renal Impairment

No specific renal dosage recommendations.

Geriatric Patients

No specific geriatric dosage recommendations.

Cautions for Amphetamine

Contraindications

Warnings/Precautions

Warnings

Sudden Death and Serious Cardiovascular Events

Sudden unexplained death, stroke, and MI reported in adults with ADHD receiving usual dosages of stimulants; sudden death also reported in children and adolescents with structural cardiac abnormalities or other serious cardiac conditions receiving usual dosages of the drugs.

Epidemiologic data suggest a possible association between use of stimulants and sudden unexplained death in healthy children and adolescents. FDA unable to conclude that these data affect evaluation of overall risk and benefit of stimulants used to treat ADHD in children and adolescents. FDA is conducting an ongoing safety review of amphetamines and other stimulants to evaluate possible link between use of these agents and sudden death in children. Pediatric patients with ADHD and their parents should avoid discontinuing the child’s use of such stimulants before consulting a clinician.

Thoroughly review medical history (including evaluation for family history of sudden death or ventricular arrhythmia) and perform physical examination in all children, adolescents, and adults being considered for stimulant therapy; if initial findings suggest presence of cardiac disease, perform further cardiac evaluation (e.g., ECG, echocardiogram).

In general, avoid use of CNS stimulants in patients with known serious structural cardiac abnormalities, cardiomyopathy, serious heart rhythm abnormalities, CAD, or other serious cardiac conditions. (See Contraindications under Cautions.)

Patients who develop exertional chest pain, unexplained syncope, or other manifestations suggestive of cardiac disease during stimulant therapy should undergo prompt cardiac evaluation.

Effects on BP and Heart Rate

Possible modest increases in average BP (i.e., by about 2–4 mm Hg) and heart rate (i.e., by about 3–6 bpm); larger increases may occur. Modest increases not expected to have short-term sequelae; however, monitor all patients for larger changes in BP and heart rate.

Caution advised in patients with underlying medical conditions that might be affected by increases in BP or heart rate (e.g., hypertension, heart failure, recent MI, ventricular arrhythmia).

Exacerbation or Precipitation of Psychotic Symptoms

May exacerbate symptoms of behavior disturbance and thought disorder in patients with preexisting psychotic disorder.

Psychotic symptoms (e.g., hallucinations, delusional thinking) may occur with usual dosages in children and adolescents without prior history of psychotic illness. If psychotic symptoms occur, consider causal relationship to stimulants, and discontinue therapy as appropriate.

Precipitation of Manic Symptoms

May precipitate mixed or manic episodes in ADHD patients with comorbid bipolar disorder; use with caution in these patients. Prior to initiating therapy, carefully screen patients with ADHD and comorbid depressive symptoms to identify risk for bipolar disorder; screening should include a detailed psychiatric history (e.g., family history of suicide, bipolar disorder, or depression).

Manic symptoms may occur with usual dosages in children and adolescents without prior history of mania. If manic symptoms occur, consider causal relationship to stimulants, and discontinue therapy as appropriate.

Aggression

Aggressive behavior and hostility (frequently observed in children and adolescents with ADHD) reported in patients receiving drug therapy for ADHD. No systematic evidence that stimulants cause these adverse effects; however, monitor patients beginning treatment for ADHD for onset or worsening of aggressive behavior or hostility.

Growth Suppression

Long-term (i.e., >14 months) administration expected to cause at least a temporary suppression of normal weight and/or height patterns in some children and adolescents. Dose-related weight loss reported in adolescents during first 4 weeks of therapy with extended-release capsules.

Manufacturers recommend monitoring growth during treatment; patients not growing or gaining weight as expected may require temporary discontinuance of treatment. However, AAP states that studies of stimulants in children found little or no decrease in expected height, with any decrease in growth early in treatment being compensated for later on.

Seizures

Possible lowering of seizure threshold in patients with history of seizures, in those with prior EEG abnormalities but no history of seizures, and, very rarely, in those without history of seizures and with no prior evidence of EEG abnormalities. If seizures occur, discontinue therapy.

Visual Effects

Visual disturbances (difficulty with accommodation, blurred vision) reported with stimulants.

General Precautions

Least amount of amphetamine feasible should be prescribed or dispensed at one time in order to minimize possible overdosage.

Tics

Amphetamines reported to exacerbate motor and phonic tics and Tourette’s syndrome. However, a history of tics or their development during therapy is not an absolute contraindication to continued use. Several controlled studies have not found stimulants to worsen or precipitate tics or Tourette’s syndrome. Nevertheless, evaluate for presence of tics and Tourette’s syndrome in children and their families prior to initiating stimulant therapy.

Use of Fixed Combination

When used in fixed combination with other agents, consider the cautions, precautions, and contraindications associated with the concomitant agents.

Specific Populations

Pregnancy

Category C.

Risk of prematurity, low birth weight, and withdrawal symptoms (e.g., dysphoria, lassitude, agitation) in infants born to dependent women.

Lactation

Distributed into milk. Discontinue nursing or the drug.

Pediatric Use

Not recommended for ADHD in children <3 years of age.

Aggressive behavior, hostility, and psychotic (e.g., hallucinations, delusional thinking) or manic symptoms reported in children and adolescents receiving stimulants for management of ADHD. (See Warnings under Cautions.)

Sudden death reported in children and adolescents with structural cardiac abnormalities or other serious cardiac conditions receiving usual dosages of stimulants. Epidemiologic data also suggest a possible association between use of stimulants and sudden death in healthy children and adolescents. (See Sudden Death and Serious Cardiovascular Events under Cautions.)

Long-term administration expected to cause at least a temporary suppression of normal weight and/or height patterns in some children and adolescents. (See Growth Suppression under Cautions.)

Geriatric Use

Not studied in geriatric patients.

Hepatic Impairment

Possible inhibition of drug elimination, resulting in prolonged exposure.

Renal Impairment

Possible inhibition of drug elimination, resulting in prolonged exposure.

Common Adverse Effects

Palpitations, tachycardia, elevation of BP, overstimulation, restlessness, dizziness, insomnia, euphoria, dyskinesia, dysphoria, tremor, headache, dryness of mouth, taste aberration, diarrhea, constipation, abdominal bloating, impotence and changes in libido.

Isolated reports of cardiomyopathy associated with chronic amphetamine use.

Anorexia and weight loss may occur as undesirable effects when amphetamines are used for other than the anorectic effect.

Drug Interactions

Inhibits MAO.

Amphetamine or metabolites modestly inhibit CYP2D6, 1A2, and 3A4 in vitro. In vivo effects on metabolism of drugs metabolized by CYP isoenzymes not known.

Specific Drugs and Laboratory Tests

Drug or Test

Interaction

Comments

Acidifying agents, GI (ascorbic acid, glutamic acid hydrochloride, reserpine)

Decreases absorption, serum concentrations, and efficacy of amphetamines

Acidifying agents, urinary (ammonium chloride, sodium acid phosphate)

Increases urinary excretion and decreases serum concentrations and efficacy of amphetamines

Adrenergic blockers

Potential inhibition of adrenergic blockade

Alkalinizing agents, GI (antacids, sodium bicarbonate)

Increases absorption and serum concentrations and potentiates the effects of amphetamines

Avoid concomitant use

Alkalinizing agents, urinary (acetazolamide and some thiazides)

Decreases urinary excretion and increases serum concentrations and potentiates the effects of amphetamines

Antidepressants, tricyclic (desipramine, protriptyline)

Enhanced activity of tricyclic antidepressants; desipramine or protriptyline cause striking and sustained increases in the concentration of dextroamphetamine in the brain; cardiovascular effects can be potentiated

Antihistamines

May counteract the sedative effects of antihistamines

Antihypertensives

May antagonize the hypotensive effects of antihypertensives

Chlorpromazine

Inhibits the central stimulant effects of amphetamines by blocking dopamine and norepinephrine receptors

Can be used to treat amphetamine poisoning

Ethosuximide

Intestinal absorption may be delayed by amphetamines

Haloperidol

Inhibits the central stimulant effects of amphetamines by blocking dopamine receptors

Lithium carbonate

May inhibit the anorectic and stimulatory effects of amphetamine

MAO inhibitors

Slow the metabolism of amphetamines, increasing their effect on the release of norepinephrine and other monoamines leading to headaches and other signs of hypertensive crisis

Toxic neurologic effects, hypertensive crisis, and malignant hyperpyrexia can occur, sometimes with fatal results

Amphetamines contraindicated in patients currently or recently (within 14 days) receiving MAO inhibitor

Meperidine

Amphetamines potentiate the analgesic effect of meperidine

Methenamine

Acidifying agents used with methenamine increase urinary excretion and decrease efficacy of amphetamines

Norepinephrine

Amphetamines enhance the adrenergic effects of norepinephrine

Phenobarbital

Amphetamines may delay absorption of phenobarbital; concomitant use may produce a synergistic anticonvulsant action

Phenytoin

Amphetamines may delay absorption of phenytoin; concomitant use may produce a synergistic anticonvulsant action

Propoxyphene

In propoxyphene overdosage, amphetamine CNS stimulation is potentiated and fatal convulsions can occur

Sympathomimetic agents

Enhanced activity of sympathomimetic agents

Test, plasma corticosteroids

Can elevate plasma corticosteroid concentrations; this increase is greatest in the evening

Test, urinary steroids

May interfere with urinary steroid determinations

Veratrum alkaloids

Amphetamines inhibit the hypotensive effect of veratrum

Amphetamine Pharmacokinetics

Absorption

Bioavailability

Plasma concentration-time profiles similar for single 20-mg extended-release dose versus two 10-mg immediate-release doses given 4 hours apart.

Peak plasma concentration and AUC decrease with increasing body weight.

Rapidly absorbed from the GI tract.

Duration

Therapeutic effects persist for 4–24 hours.

Food

Food does not affect the extent of absorption of the extended-release preparation (Adderall XR), but prolongs Tmax by 2.5 hours (for d-amphetamine) and 2.1 hours (for l-amphetamine). Opening the capsule and sprinkling the contents on applesauce results in comparable absorption to the intact capsule taken in the fasted state.

Plasma Concentrations

Tmax, immediate-release: About 3 hours.

Tmax, extended-release: About 7 hours.

Therapeutic plasma concentrations are 5–10 mcg/dL.

Distribution

Extent

Distributed widely throughout body, with high levels in the brain.

Apparently crosses the placenta since withdrawal manifestations have occurred in neonates.

Distributed into milk in concentrations 3–7 times maternal blood concentrations.

Volume of distribution increases with increasing body weight.

Elimination

Metabolism

Metabolized to several active metabolites.

Enzymes involved in metabolism not clearly defined; however, CYP2D6 is involved with formation of at least one metabolite. Because CYP2D6 is genetically polymorphic, potential variability in metabolism among patients exists.

Elimination Route

With normal urinary pH, excreted in urine as unchanged drug (approximately 30–40%) and metabolites (approximately 50%). Changes in urinary pH may alter excretion; urinary recovery of unchanged drug reported to range from 1–75%, depending on urinary pH. (See Specific Drugs and Laboratory Tests under Interactions.)

Clearance increases with increasing body weight. On a mg/kg basis, however, children have higher clearance than adolescents or adults.

Half-life

Children 6–12 years of age: 9 hours (for d-amphetamine) or 11 hours (for l-amphetamine).

Adolescents 13–17 years of age: 11 hours (for d-amphetamine) or 13–14 hours (for l-amphetamine).

Adults: 10 hours (for d-amphetamine) or 13 hours (for l-amphetamine).

Elimination half-life increases with increasing body weight.

Stability

Storage

Oral

Extended-release Capsules and Conventional Tablets

Tight, light-resistant containers at 25°C (may be exposed to 15–30°C).

Actions

Advice to Patients

Preparations

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

Subject to control under the Federal Controlled Substances Act of 1970 as schedule II (C-II) drugs.

Amphetamine Sulfate Combinations

Routes

Dosage Forms

Strengths

Brand Names

Manufacturer

Oral

Capsules, extended-release

5 mg total amphetamine (as 1.25 mg, with Amphetamine Aspartate 1.25 mg, Dextroamphetamine Saccharate 1.25 mg, and Dextroamphetamine Sulfate 1.25 mg)

Adderall XR ( C-II)

Shire

10 mg total amphetamine (as 2.5 mg, with Amphetamine Aspartate 2.5 mg, Dextroamphetamine Saccharate 2.5 mg, and Dextroamphetamine Sulfate 2.5 mg)

Adderall XR ( C-II)

Shire

15 mg total amphetamine (as 3.75 mg, with Amphetamine Aspartate 3.75 mg, Dextroamphetamine Saccharate 3.75 mg, and Dextroamphetamine Sulfate 3.75 mg)

Adderall XR ( C-II)

Shire

20 mg total amphetamine (as 5 mg, with Amphetamine Aspartate 5 mg, Dextroamphetamine Saccharate 5 mg, and Dextroamphetamine Sulfate 5 mg)

Adderall XR ( C-II)

Shire

25 mg total amphetamine (as 6.25 mg, with Amphetamine Aspartate 6.25 mg, Dextroamphetamine Saccharate 6.25 mg, and Dextroamphetamine Sulfate 6.25 mg)

Adderall XR ( C-II)

Shire

30 mg total amphetamine (as 7.5 mg, with Amphetamine Aspartate 7.5 mg, Dextroamphetamine Saccharate 7.5 mg, and Dextroamphetamine Sulfate 7.5 mg)

Adderall XR ( C-II)

Shire

Tablets

5 mg total amphetamine (as 1.25 mg, with Amphetamine Aspartate 1.25 mg, Dextroamphetamine Saccharate 1.25 mg, and Dextroamphetamine Sulfate 1.25 mg)

Adderall ( C-II; double-scored)

Shire

Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, and Amphetamine Sulfate Tablets ( C-II; double-scored)

Barr

7.5 mg total amphetamine (as 1.875 mg, with Amphetamine Aspartate 1.875 mg, Dextroamphetamine Saccharate 1.875 mg, and Dextroamphetamine Sulfate 1.875 mg)

Adderall ( C-II; double-scored)

Shire

Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, and Amphetamine Sulfate Tablets ( C-II; double-scored)

Barr

10 mg total amphetamine (as 2.5 mg, with Amphetamine Aspartate 2.5 mg, Dextroamphetamine Saccharate 2.5 mg, and Dextroamphetamine Sulfate 2.5 mg)

Adderall ( C-II; double-scored)

Shire

Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, and Amphetamine Sulfate Tablets ( C-II; double-scored)

Barr

12.5 mg total amphetamine (as 3.125 mg, with Amphetamine Aspartate 3.125 mg, Dextroamphetamine Saccharate 3.125 mg, and Dextroamphetamine Sulfate 3.125 mg)

Adderall ( C-II; double-scored)

Shire

Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, and Amphetamine Sulfate Tablets ( C-II; double-scored)

Barr

15 mg total amphetamine (as 3.75 mg, with Amphetamine Aspartate 3.75 mg, Dextroamphetamine Saccharate 3.75 mg, and Dextroamphetamine Sulfate 3.75 mg)

Adderall ( C-II; double-scored)

Shire

Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, and Amphetamine Sulfate Tablets ( C-II; double-scored)

Barr

20 mg total amphetamine (as 5 mg, with Amphetamine Aspartate 5 mg, Dextroamphetamine Saccharate 5 mg, and Dextroamphetamine Sulfate 5 mg)

Adderall ( C-II; double-scored)

Shire

Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, and Amphetamine Sulfate Tablets ( C-II; double-scored)

Barr

30 mg total amphetamine (as 7.5 mg, with Amphetamine Aspartate 7.5 mg, Dextroamphetamine Saccharate 7.5 mg, and Dextroamphetamine Sulfate 7.5 mg)

Adderall ( C-II; double-scored)

Shire

Dextroamphetamine Saccharate, Amphetamine Aspartate, Dextroamphetamine Sulfate, and Amphetamine Sulfate Tablets ( C-II; double-scored)

Barr

AHFS DI Essentials™. © Copyright 2024, Selected Revisions May 18, 2023. American Society of Health-System Pharmacists, Inc., 4500 East-West Highway, Suite 900, Bethesda, Maryland 20814.

† Off-label: Use is not currently included in the labeling approved by the US Food and Drug Administration.

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