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Invirase and Alcohol/Food Interactions

There are 2 alcohol/food/lifestyle interactions with Invirase (saquinavir).

Moderate

saquinavir food

Moderate Food Interaction

Food can enhance the levels of saquinavir in your body. Saquinavir should be taken with meals or within 2 hours after eating. This will make it easier for your body to absorb the medication. Grapefruit can raise the levels of saquinavir in your body. Discuss the use of grapefruit products with your doctor. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor.

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Moderate

High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)

Moderate Potential Hazard, Moderate plausibility

PIs - hyperlipidemia

Treatment with ritonavir alone or in combination with other protease inhibitors (e.g., lopinavir, saquinavir, tipranavir, fosamprenavir) has resulted in substantial increases in the concentration of total cholesterol and triglycerides. These effects have also been reported with other protease inhibitors but may be the most dramatic with ritonavir. The clinical significance of these elevations is unclear. Marked elevation in triglyceride levels is a risk factor for development of pancreatitis. Triglyceride and cholesterol testing is recommended before starting ritonavir (with or without other protease inhibitors) and periodically during therapy. Lipid disorders should be managed as clinically appropriate.

References

  1. "Product Information. Norvir (ritonavir)." AbbVie US LLC SUPPL-25 (2022):
  2. "Product Information. Reyataz (atazanavir)." Bristol-Myers Squibb SUPPL-44 (2020):
  3. "Product Information. Lexiva (fosamprenavir)." ViiV Healthcare SUPPL-41 (2019):
  4. "Product Information. Kaletra (lopinavir-ritonavir)." AbbVie US LLC SUPPL-54 (2020):
  5. "Product Information. Invirase (saquinavir)." Roche Laboratories SUPPL-25 (2020):
  6. "Product Information. Aptivus (tipranavir)." Boehringer Ingelheim SUPPL-21 (2020):
View all 6 references

Invirase drug interactions

There are 681 drug interactions with Invirase (saquinavir).

Invirase disease interactions

There are 6 disease interactions with Invirase (saquinavir) which include:

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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