Exparel Interactions
There are 126 drugs known to interact with Exparel (bupivacaine liposome), along with 3 disease interactions. Of the total drug interactions, 23 are major, 101 are moderate, and 2 are minor.
- View all 126 medications that may interact with Exparel
- View Exparel disease interactions (3)
Most frequently checked interactions
View interaction reports for Exparel (bupivacaine liposome) and the medicines listed below.
- acetaminophen
- Aimovig (erenumab)
- Benadryl (diphenhydramine)
- biotin
- bisacodyl
- cefdinir
- cephalexin
- cetirizine
- clindamycin
- cyclobenzaprine
- Decadron (dexamethasone)
- diazepam
- diclofenac topical
- Dilaudid (hydromorphone)
- doxycycline
- famotidine
- fentanyl
- Flagyl (metronidazole)
- fluconazole
- folic acid
- gabapentin
- hydroxyzine
- ibuprofen
- Keflex (cephalexin)
- Lovenox (enoxaparin)
- prednisone
- tramadol
- Vitamin B12 (cyanocobalamin)
- Vitamin C (ascorbic acid)
- Vitamin D3 (cholecalciferol)
Exparel disease interactions
There are 3 disease interactions with Exparel (bupivacaine liposome) which include:
More about Exparel (bupivacaine liposome)
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- Drug class: local injectable anesthetics
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Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.