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Exparel Disease Interactions

There are 3 disease interactions with Exparel (bupivacaine liposome).

Moderate

Bupivacaine (applies to Exparel) cardiovascular disease

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Arrhythmias

Bupivacaine and other amide- containing products should be used with caution in patients with impaired cardiovascular function, as they may be less able to compensate for functional changes associated with the prolongation of AV conduction produced by these drugs. Toxic blood concentrations can depress cardiac conductivity and excitability, which can lead to atrioventricular block, ventricular arrhythmias, and cardiac arrest. In addition, myocardial contractility is depressed and peripheral vasodilation occurs, leading to decreased cardiac output and arterial blood pressure.

References

  1. "Product Information. Marcaine HCl (bupivacaine)." Hospira Inc (2008):
  2. "Product Information. Exparel (BUPivacaine liposome)." Pacira Pharmaceuticals Inc (2011):
Moderate

Bupivacaine (applies to Exparel) liver disease

Moderate Potential Hazard, Moderate plausibility.

Amide-type local anesthetics, such as bupivacaine, are metabolized by the liver. Bupivacaine should be used cautiously in patients with hepatic disease. Patients with severe hepatic disease, because of their inability to metabolize local anesthetics normally, are at a greater risk of developing toxic plasma concentrations.

References

  1. "Product Information. Marcaine HCl (bupivacaine)." Hospira Inc (2008):
  2. "Product Information. Exparel (BUPivacaine liposome)." Pacira Pharmaceuticals Inc (2011):
Moderate

Bupivacaine (applies to Exparel) renal impairment

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction

Bupivacaine is substantially excreted by the kidney, and the risk of toxic reactions may be greater in patients with impaired renal function. Care should be taken in dose selection in patients with renal impairment.

References

  1. "Product Information. Marcaine HCl (bupivacaine)." Hospira Inc (2008):
  2. "Product Information. Exparel (BUPivacaine liposome)." Pacira Pharmaceuticals Inc (2011):

Exparel drug interactions

There are 126 drug interactions with Exparel (bupivacaine liposome).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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