Tolterodine Dosage

Medically reviewed by Drugs.com. Last updated on Jul 17, 2023.

Usual Adult Dose for Urinary Incontinence

Immediate release tablets:

• Initial dose: 2 mg orally 2 times a day
• Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerability

Extended release capsules:

• Initial dose: 4 mg orally once a day
• Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerability

Comments:

• This drug can be taken with or without food.
• The extended release formulation should be swallowed whole.

Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency

Usual Adult Dose for Urinary Frequency

Immediate release tablets:

• Initial dose: 2 mg orally 2 times a day
• Maintenance dose: 1 to 2 mg orally 2 times a day, depending on patient response and tolerability

Extended release capsules:

• Initial dose: 4 mg orally once a day
• Maintenance dose: 2 to 4 mg orally once a day, depending on patient response and tolerability

Comments:

• This drug can be taken with or without food.
• The extended release formulation should be swallowed whole.

Use: For the treatment of overactive bladder (OAB) with symptoms of urge urinary incontinence, urgency, and frequency

Renal Dose Adjustments

• Severe renal impairment (CrCl 10 to 30 mL/min):

Tablets: 1 mg orally 2 times a day
Extended release capsules: 2 mg orally once a day

• End stage renal disease (CrCl less than 10 mL/min):

Use is not recommended

Liver Dose Adjustments

• Mild to moderate hepatic impairment (Child-Pugh Class A or B):

Immediate release formulation: 1 mg orally 2 times a day
Extended release formulation: 2 mg orally 2 times a day

• Severe hepatic impairment (Child-Pugh Class C):

Not recommended

Dose Adjustments

Concomitant use of potent CYP450 3A4 inhibitors:
Immediate release formulation: 1 mg orally 2 times a day
Extended release formulation: 2 mg orally once a day

Precautions

Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.

Dialysis

Data not available

Other Comments

Administration advice:

• This drug can be taken with or without food.

General:

• Treatment effect should be reevaluated after 2 to 6 months.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer