Applies to the following strength(s): 2.5 mg ; 5 mg
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Diabetes Type 2
2.5 or 5 mg orally once a day, regardless of meals
Coadministration with strong CYP450 3A4/5 inhibitors: 2.5 mg orally once a day
Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes in multiple clinical settings
Renal Dose Adjustments
Mild renal dysfunction (CrCl more than 50 mL/min): No adjustment recommended.
Moderate or severe renal dysfunction (CrCl 50 mL/min or less): 2.5 mg orally once a day, regardless of meals
Liver Dose Adjustments
No adjustment recommended.
Concomitant use with an insulin secretagogue or with insulin: A lower dose of insulin secretagogue or insulin may be required to minimize the risk of hypoglycemia.
Safety and efficacy have not been established in patients younger than 18 years.
Consult WARNINGS section for additional precautions.
Hemodialysis: 2.5 mg following hemodialysis
Peritoneal dialysis: Has not been study in this population
-Tablets should not be split or cut.
-This drug can be taken with or without food.
-If a dose is missed, take the next dose as prescribed, unless otherwise instructed. Instruct patient not take an extra dose the next day.
General: A 10 mg dosage is not an approved dosage
-Hematologic: Blood glucose and HbA1c
-Persistent severe abdominal pain, sometimes radiating to the back is a hallmark symptom for acute pancreatitis.
-Report to the provider if these symptoms occur.
-Instruct patients to contact their health care provider if they develop severe and persistent joint pain.
More about saxagliptin
- Other brands: Onglyza