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Saxagliptin Dosage

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Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Diabetes Type 2

2.5 or 5 mg orally once a day, regardless of meals

Coadministration with strong CYP450 3A4/5 inhibitors: 2.5 mg orally once a day

Use: Adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes in multiple clinical settings

Renal Dose Adjustments

Mild renal dysfunction (CrCl more than 50 mL/min): No adjustment recommended.
Moderate or severe renal dysfunction (CrCl 50 mL/min or less): 2.5 mg orally once a day, regardless of meals

Liver Dose Adjustments

No adjustment recommended.

Dose Adjustments

Concomitant use with an insulin secretagogue or with insulin: A lower dose of insulin secretagogue or insulin may be required to minimize the risk of hypoglycemia.


Safety and efficacy have not been established in patients younger than 18 years.

Consult WARNINGS section for additional precautions.


Hemodialysis: 2.5 mg following hemodialysis
Peritoneal dialysis: Has not been study in this population

Other Comments

Administration advice:
-Tablets should not be split or cut.
-This drug can be taken with or without food.
-If a dose is missed, take the next dose as prescribed, unless otherwise instructed. Instruct patient not take an extra dose the next day.

General: A 10 mg dosage is not an approved dosage

-Hematologic: Blood glucose and A1C

Patient advice:
-Persistent severe abdominal pain, sometimes radiating to the back is a hallmark symptom for acute pancreatitis.
-Report to the provider if these symptoms occur.