Saxagliptin Dosage
This dosage information may not include all the information needed to use Saxagliptin safely and effectively. See additional information for Saxagliptin.
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Diabetes Mellitus Type II
2.5 mg or 5 mg once daily taken regardless of meals based upon renal function. Assessment of renal function is recommended prior to initiation of saxagliptin and periodically thereafter.
Renal Dose Adjustments
No dosage adjustment is recommended for patients with mild renal impairment (creatinine clearance [CrCl] greater than 50 mL/min). The dose is 2.5 mg once daily for patients with moderate or severe renal impairment, or with end-stage renal disease (ESRD) requiring hemodialysis (creatinine clearance [CrCl] less than 50 mL/min). Saxagliptin should be administered following hemodialysis. Saxagliptin has not been studied in patients undergoing peritoneal dialysis. Because the dose of saxagliptin should be limited to 2.5 mg based upon renal function, assessment of renal function is recommended prior to initiation of saxagliptin and periodically thereafter. Renal function can be estimated from serum creatinine using the Cockcroft-Gault formula or Modification of Diet in Renal Disease formula.
Liver Dose Adjustments
Data not available
Precautions
Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).
Dialysis
The dose is 2.5 mg once daily for patients with requiring hemodialysis (creatinine clearance [CrCl] less than 50 mL/min). Saxagliptin should be administered following hemodialysis. Saxagliptin has not been studied in patients undergoing peritoneal dialysis.
