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Glyburide / Metformin Dosage

Applies to the following strength(s): 1.25 mg-250 mg ; 2.5 mg-500 mg ; 5 mg-500 mg

The information at is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Additional dosage information:

Usual Adult Dose for Diabetes Type 2

Initial therapy:

1 tablet (1.25 mg-250 mg) orally once or twice daily with meals.

Previously treated patients:

1 tablet (2.5 mg-500 mg) orally twice daily with meals.


1 tablet (5 mg- 500 mg) orally twice daily with meals.

Comments: Glyburide-metformin should be administered at least 4 hours prior to colesevelam to ensure that colesevelam does not reduce the absorption of glyburide-metformin.

Renal Dose Adjustments

Metformin, when used in patients with renal insufficiency (based on an estimated creatinine clearance <80 mL/min), can precipitate lactic acidosis. Because of this potentially life-threatening metabolic effect, the use of metformin in patients with renal disease is not recommended.

Liver Dose Adjustments

Because metformin can precipitate lactic acidosis and because liver disease may decrease the elimination of lactate, the use of metformin in patients with liver disease is not recommended.

Dose Adjustments

Dosages may be gradually titrated to achieve the desired antihyperglycemic effect. Dosage increases should be made in increments of 1.25 mg-250 mg per day every two weeks. The maximum recommended daily dose is 10 mg-2000 mg per day.


Metformin treatment should not be initiated in patients 80 or more years of age unless measurement of creatinine clearance demonstrates that renal function is not reduced.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).


No data available.

Other Comments

Transfer of patients from other oral hypoglycemic agents should be done conservatively. Although no waiting period between agents is necessary, patients switched from longer acting agents, such as chlorpropamide, should be carefully monitored for hypoglycemia during the first two weeks of therapy. The initial dosage of glyburide-metformin as second-line therapy recommended for previously treated patients is 1.25 mg-250 mg or 2.5 mg-500 mg twice a day with the morning and evening meals. The starting dose of glyburide-metformin should not exceed the daily doses of glyburide or metformin already being taken. The daily dosage should be titrated in increments of not more than 5 mg-500 mg.