Glumetza Dosage

Adult Dosage and Administration

• • The recommended starting dose of GLUMETZA is 500 mg orally once daily with the evening meal.
• • Increase the dose in increments of 500 mg every 1 to 2 weeks on the basis of glycemic control and tolerability, up to
• a maximum of 2,000 mg once daily with the evening meal.
• • Patients receiving metformin hydrochloride (HCl) may be switched to GLUMETZA once daily at the same total
• daily dose, up to 2,000 mg once daily.
• • Swallow GLUMETZA whole and never crush, cut or chew.
• • If a dose of GLUMETZA is missed, instruct patients not to take two doses the same day and to resume their usual
• dose of GLUMETZA with the next schedule dose.

Recommendations for Use in Renal Impairment

• • Assess renal function prior to initiation of GLUMETZA and periodically thereafter.
• • GLUMETZA is contraindicated in patients with an estimated glomerular filtration rate (eGFR) below
• 30 mL/minute/1.73 m2.
• • Initiation of GLUMETZA in patients with an eGFR between 30 to 45 mL/minute/1.73 m2 is not recommended.
• • In patients taking GLUMETZA whose eGFR later falls below 45 mL/minute/1.73 m2, assess the benefit risk of
• continuing therapy.
• • Discontinue GLUMETZA if the patient’s eGFR later falls below 30 mL/minute/1.73 m2 [see Contraindications (4) and Warnings and Precautions ( 5.1)].

Discontinuation for Iodinated Contrast Imaging Procedures

Discontinue GLUMETZA at the time of, or prior to, an iodinated contrast imaging procedure in patients with an eGFR between 30 and 60 mL/minute/1.73 m2; in patients with a history of liver disease, alcoholism or heart failure; or in patients who will be administered intra-arterial iodinated contrast. Re-evaluate eGFR 48 hours after the imaging procedure; restart GLUMETZA if renal function is stable [see Warnings and Precautions ( 5.1)].