Medication Guide App

Erwinaze Dosage

Generic name: asparaginase
Dosage form: injection, powder, lyophilized, for solution

This dosage information does not include all the information needed to use Erwinaze safely and effectively. See full prescribing information for Erwinaze.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Recommended Dose

To substitute for a dose of pegaspargase:

                The recommended dose is 25,000 International Units/m2 administered intramuscularly three times a week Monday/Wednesday/Friday) for six doses for each planned dose of pegaspargase.  

To substitute for a dose of native E. coli asparaginase:

                The recommended dose is 25,000 International Units/m2 administered intramuscularly for each scheduled dose of native E. coli asparaginase within a treatment. 

Preparation Instructions

1.
Visually inspect the ERWINAZE powder for foreign particulate matter and discoloration prior to reconstitution. Discard vial if present.
2.
Reconstitute the contents of each vial by slowly injecting 1 or 2 mL of preservative-free sterile sodium chloride (0.9%) injection (USP) against the inner vial wall. 
3.
Do not forcefully inject solution for reconstitution directly onto or into the powder.  When reconstituted with 1 mL the resultant concentration is 10, 000 International Units per mL.  When reconstituted with 2 mL the resultant concentration is 5,000 International Units per mL.
4.
Dissolve contents by gentle mixing or swirling.  Do not shake or invert vial.
5.
When reconstituted, ERWINAZE should be a clear, colorless solution. Discard the reconstituted solution if any visible particles or protein aggregates are present.
6.
Calculate the dose needed and the volume needed to obtain the calculated dose.
7.
Withdraw the volume containing the calculated dose from the vial into a polypropylene syringe within 15 minutes of reconstitution. Do not freeze or refrigerate reconstituted solution and administer within 4 hours or discard.
[see How Supplied (16)].

Administration Instructions

1.
Inject ERWINAZE solution intramuscularly.
2.
Limit the volume of reconstituted ERWINAZE at a single injection site to 2 mL; if reconstituted dose to be administered is greater than 2 mL, use multiple injection sites.
3.
If a partial vial is used, do not save or reuse the unused drug for later administration. Discard unused portions.
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