Asparaginase erwinia chrysanthemi Pregnancy and Breastfeeding Warnings

Asparaginase erwinia chrysanthemi is also known as: Erwinaze

Asparaginase erwinia chrysanthemi Pregnancy Warnings

Use is recommended only if clearly needed and the benefit outweighs the risk. US FDA pregnancy category: C

In animal studies, maternal toxicities of decreased body weight and decreased body weight gain and fetal findings of increased incidence of partially undescended thymic tissue, increased post-implantation loss, decreased number of live fetuses, and gross abnormalities were observed. There are no controlled data in human pregnancy. US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Asparaginase erwinia chrysanthemi Breastfeeding Warnings

Use is not recommended and a decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother. Excreted into human milk: Unknown Excreted into animal milk: Data not available Comments: The effects in the nursing infant are unknown.

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