Erwinaze Side Effects

Generic name: asparaginase erwinia chrysanthemi

Note: This document contains side effect information about asparaginase erwinia chrysanthemi. Some of the dosage forms listed on this page may not apply to the brand name Erwinaze.

Some side effects of Erwinaze may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to asparaginase erwinia chrysanthemi: intramuscular powder for injection

Get emergency medical help if you have any of these signs of an allergic reaction while taking asparaginase erwinia chrysanthemi (the active ingredient contained in Erwinaze) hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• severe pain in your upper stomach spreading to your back, nausea and vomiting, fast heart rate;

• easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin;

• any bleeding that will not stop;

• fever;

• seizure (convulsions);

• sudden numbness or weakness, especially on one side of the body;

• sudden severe headache, confusion, problems with vision, speech, or balance;

• chest pain, sudden cough, wheezing, rapid breathing, coughing up blood;

• pain, swelling, warmth, or redness in one or both legs; or

• high blood sugar (increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss).

Common side effects may include:

• mild nausea;

• diarrhea; or

• mild stomach pain.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to asparaginase erwinia chrysanthemi: intramuscular powder for injection

Endocrine

Endocrine side effects have included pancreatitis.

Gastrointestinal

Gastrointestinal side effects have included nausea and vomiting.

Hematologic

Hematologic side effects have included coagulation abnormalities including thrombosis and hemorrhage.

Hypersensitivity

Hypersensitivity reactions have included hypersensitivity reaction including anaphylaxis.

Metabolic

Laboratory abnormalities have included hyperglycemia and abnormal transaminases.

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