Clindamycin Topical Dosage

This dosage information may not include all the information needed to use Clindamycin Topical safely and effectively. See additional information for Clindamycin Topical.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Acne

Gel [except Clindagel(R)], lotion, solution: Apply to affected areas twice a day.
Clindagel(R), foam: Apply to affected areas once a day.

Usual Adult Dose for Bacterial Vaginosis

Vaginal cream: Insert 1 applicatorful intravaginally once a day, preferably at bedtime. Therapy should continue for 3 or 7 consecutive days in nonpregnant patients and for 7 consecutive days if the patient is pregnant and in the second or third trimester.

Alternatively, a single applicatorful of Clindesse(R) may be administered intravaginally to nonpregnant women once at any time of the day.

Vaginal suppository: Insert 1 suppository intravaginally once a day, preferably at bedtime, for 3 consecutive days.

Usual Pediatric Dose for Acne

12 years or older:
Gel [except Clindagel(R)], lotion, solution: Apply to affected areas twice a day.
Clindagel(R), foam: Apply to affected areas once a day.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Dose Adjustments

Prolonged therapy may be necessary for the treatment of acne vulgaris.

Precautions

Clindamycin topical is contraindicated in patients with a history of regional enteritis, ulcerative colitis, or a history of antibiotic-associated colitis (including pseudomembranous colitis).

Systemic absorption of clindamycin has been demonstrated following use of clindamycin topical. Diarrhea, bloody diarrhea, and colitis (including pseudomembranous colitis) have been reported with the use of clindamycin topical. The drug should be discontinued if significant diarrhea develops. In cases of severe diarrhea, large bowel endoscopy should be considered to establish a definitive diagnosis. Patients should be advised to discontinue use of clindamycin topical and consult a physician if diarrhea develops.

Studies have indicated that a toxin(s) produced by Clostridia is one primary cause of antibiotic-associated colitis. The colitis is normally characterized by severe persistent diarrhea and severe abdominal cramps and may be associated with the passage of blood and mucus. Pseudomembranous colitis may be revealed by endoscopic examination. Stool culture of Clostridium difficile and stool assay for C difficile toxin may be useful diagnostically.

Clindamycin vaginal cream contains mineral oil which can weaken latex or rubber products. Condoms or diaphragms should not be used concurrently or for 5 days following clindamycin vaginal cream. Patients should generally be advised to avoid sexual intercourse during therapy.

Clindamycin topical foam can cause irritation. Concomitant topical acne therapy should be used with caution since possible cumulative irritancy effects may occur, especially with use of peeling, desquamating, or abrasive agents. If irritation or dermatitis occurs, clindamycin topical should be discontinued.

Avoid contact of clindamycin topical foam with eyes, mouth, lips, other mucous membranes, or areas of broken skin. Rinse thoroughly with water if accidental exposure occurs.

Clindamycin topical solution contains an alcohol base that will cause irritation and burning of the eye. In the event of accidental contact with sensitive surfaces (eye, mucous membranes, abraded skin), bathe with copious amounts of cool tap water. The solution has an unpleasant taste and caution should be exercised when applying the drug around the mouth.

Caution should be exercised when using clindamycin topical in atopic patients, including those with hypersensitivity to environmental allergens.

Safety and effectiveness of clindamycin topical foam, gel, lotion, and solution have not been established in pediatric patients less than 12 years of age. Safety and effectiveness of clindamycin vaginal products have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

Bacterial vaginosis is usually defined by the presence of a homogeneous vaginal discharge with the following:
- a pH greater than 4.5
- a 'fishy' amine odor when mixed with 10% KOH solution
- presence of clue cells on microscopic examination

Clindamycin topical foam should be discontinued if there has been no improvement after 6 to 8 weeks of therapy or if the condition becomes worse.

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