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Clindamycin topical Pregnancy and Breastfeeding Warnings

Clindamycin topical is also known as: C/T/S, Cleocin Ovules, Cleocin T, Cleocin Vaginal, Clinda-Derm, ClindaReach Pledget, Clindacin ETZ, Clindacin P, Clindacin PAC, Clindagel, Clindamax, Clindesse, Clindets, Clindets Pledget, Evoclin, Pledgaclin

Clindamycin topical Pregnancy Warnings

Topical and vaginal clindamycin have been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of teratogenicity when high doses of clindamycin are given systemically. There are no controlled data in human pregnancy. Clindamycin topical, and vaginal preparation, is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.

In a review of 229,101 deliveries to Michigan Medicaid patients, 647 first-trimester exposures to clindamycin and 1587 exposures any time during pregnancy were recorded. Both systemic and nonsystemic exposures were included. A total of 31 birth defects were reported with first trimester exposures (28 expected) and included (observed/expected) 5/6 cardiovascular defects, 1 spina bifida, 1 polydactyly, and 3 hypospadias (written communication, Franz Rosa, MD, Food and Drug Administration, 1994). Clindamycin topical is approved for use in pregnant women during the second trimester.

See references

Clindamycin topical Breastfeeding Warnings

There are no data on the excretion of clindamycin into human milk following topical or vaginal exposure. Clindamycin is excreted following systemic administration. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. "Product Information. Cleocin vaginal cream (clindamycin)." Pharmacia and Upjohn, Kalamazoo, MI.
  2. "Product Information. Cleocin T (clindamycin)." Pharmacia and Upjohn, Kalamazoo, MI.
  3. "Product Information. Clindesse (clindamycin topical)." Ther-Rx Corporation, Bridgeton, MO.

References for breastfeeding information

  1. Committee on Drugs, 1992 to 1993 "The transfer of drugs and other chemicals into human milk." Pediatrics 93 (1994): 137-50
  2. "Product Information. Evoclin (clindamycin topical)." Connetics Inc, Palo Alto, CA.
  3. "Product Information. Cleocin vaginal cream (clindamycin)." Pharmacia and Upjohn, Kalamazoo, MI.
  4. "Product Information. Cleocin T (clindamycin)." Pharmacia and Upjohn, Kalamazoo, MI.

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