Clindamycin topical Pregnancy and Breast Feeding Warnings
Clindamycin topical is also known as: C/T/S, Cleocin Ovules, Cleocin T, Cleocin Vaginal, Clinda-Derm, Clindagel, Clindamax, ClindaReach Pledget, Clindesse, Clindets, Clindets Pledget, Evoclin
Overview
It is not known if Clindamycin Foam can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using Clindamycin Foam while you are pregnant. It is not known if Clindamycin Foam is found in breast milk. Do not breast-feed while taking Clindamycin Foam.
Clindamycin topical Pregnancy Warnings
Topical and vaginal clindamycin have been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal evidence of teratogenicity when high doses of clindamycin are given systemically. There are no controlled data in human pregnancy. Clindamycin topical, and vaginal preparation, is only recommended for use during pregnancy when there are no alternatives and benefit outweighs risk.
In a review of 229,101 deliveries to Michigan Medicaid patients, 647 first-trimester exposures to clindamycin and 1587 exposures any time during pregnancy were recorded. Both systemic and nonsystemic exposures were included. A total of 31 birth defects were reported with first trimester exposures (28 expected) and included (observed/expected) 5/6 cardiovascular defects, 1 spina bifida, 1 polydactyly, and 3 hypospadias (written communication, Franz Rosa, MD, Food and Drug Administration, 1994). Clindamycin topical is approved for use in pregnant women during the second trimester.
Clindamycin topical Lactation Warnings
There are no data on the excretion of clindamycin into human milk following topical or vaginal exposure. Clindamycin is excreted following systemic administration. The manufacturer recommends that due to the potential for serious adverse reactions in nursing infants, a decision should be made to discontinue the drug, taking into account the importance of the drug to the mother.
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