Applies to the following strength(s): 12.5 mg ; 25 mg ; 6.25 mg
The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.
Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Diabetes Type 2
25 mg once daily
Comments: Take with or without food
Renal Dose Adjustments
Mild renal dysfunction (CrCl greater than or equal to 60 mL/min): No adjustment recommended
Moderate renal dysfunction (CrCl greater than or equal to 30 mL/min to less than 60 mL/min): 12.5 mg once daily
Severe renal dysfunction (CrCl greater than or equal to 15 mL/min to less than 30 mL/min) and end-stage renal disease (ESRD) (CrCl less than 15 mL/min or requiring hemodialysis): 6.25 mg once daily
Comments: Administer without regard to the timing of dialysis. Data not available for patients undergoing peritoneal dialysis.
Liver Dose Adjustments
Mild to moderate liver dysfunction (Child-Pugh Grade A and B): No adjustment recommended
Severe liver dysfunction (Child-Pugh C): Data not available. Use caution when administering to patients with liver disease
Consult WARNINGS section for dosing related precautions
Minimally dialyzable (7% drug removal over 3 hours) and no dose adjustment guidelines have been reported.
Administration advice: Take with or without food.
Patient advice: Hypoglycemia can occur when used with insulin or an insulin secretagogue.
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- Other brands: Nesina