Alogliptin / Pioglitazone Dosage
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Usual Adult Dose for:
Additional dosage information:
Usual Adult Dose for Diabetes Type 2
For patients inadequately controlled on diet and exercise, inadequately controlled on metformin monotherapy, on alogliptin who require additional glycemic control: 25 mg/15 mg or 25
mg/30 mg once daily
For patients on pioglitazone who require additional glycemic control: 25 mg/15 mg, 25 mg/30 mg, or 25 mg/45 mg once daily as appropriate based upon current therapy
For patients with congestive heart failure (NYHA Class I or II): 25 mg/15 mg once daily
Maximum dose: up to 25 mg/45 mg once daily based on A1C
Comments: For patients switching from alogliptin coadministered with pioglitazone, initiate the dose of alogliptin and pioglitazone based upon current therapy
Renal Dose Adjustments
Mild renal dysfunction (CrCl greater than or equal to 60 mL/min): No adjustment recommended.
Moderate renal dysfunction (CrCl greater than or equal to 30 mL/min to less than 60 mL/min): 12.5 mg/15 mg, 12.5 mg/30 mg, or 12.5 mg/45 mg once daily
Severe renal dysfunction or ESRD: Not recommended. Coadministration of pioglitazone and alogliptin 6.25 mg once daily based on individual requirements may be considered in these patients.
Liver Dose Adjustments
Mild to moderate liver dysfunction (Child-Pugh Grade A and B): No adjustment recommended
Severe liver dysfunction (Child-Pugh Grade C): Use with caution in patients with liver disease
Moderate to severe liver dysfunction (Child-Pugh Grade B and D): No adjustment recommended, use with caution in patients with liver disease
The maximum recommended dose when used in combination with gemfibrozil or other strong CYP2C8 inhibitors: 25 mg/15 mg daily
Consult WARNINGS section for dosing related precautions
Alogliptin: Minimally dialyzable (7% drug removal over 3 hours) and no dose adjustment guidelines have been reported
Pioglitazone: Data not available
Administration advice: Take with or without food
Patient advice: Hypoglycemia can occur when used with insulin or an insulin secretagogue. Treatment may increase risk for pregnancy and all premenopausal women should use adequate contraception.
More about alogliptin/pioglitazone
- Other brands: Oseni