Alfuzosin Dosage

Usual Adult Dose for Benign Prostatic Hyperplasia

10 mg orally once a day immediately after the same meal each day.

Renal Dose Adjustments

The manufacturer recommends that caution be exercised when alfuzosin is used to treat patients with severe renal insufficiency.

Liver Dose Adjustments

Contraindicated in moderate to severe hepatic insufficiency (Child-Pugh B and C).

Precautions

Use of alfuzosin is contraindicated in patients with moderate or severe hepatic insufficiency.

Concomitant use of alfuzosin and potent inhibitors of CYP450 3A4 (e.g., ketoconazole, itraconazole) is contraindicated.

Since benign prostatic hyperplasia (BPH) and carcinoma of the prostate are related and may coexist, it is recommended that all patients with BPH be screened for prostate cancer.

It is recommended that patients be informed of the possibility of orthostatic hypotension and the risk of syncope.

If symptoms of angina pectoris appear or worsen during alfuzosin therapy, the drug should be discontinued.

Intraoperative Floppy Iris Syndrome (IFIS) has been observed in some patients undergoing phacoemulsification cataract surgery. If a patient is considering cataract surgery, their ophthalmologist should be prepared for possible modifications to their surgical technique that may be necessary should IFIS be observed during the procedure.

Caution is advised when using alfuzosin in patients with a known history of QT interval prolongation or in patients who are taking medications that prolong the QT interval.

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Data not available

Other Comments

The tablets should not be chewed or crushed.

Alfuzosin should be administered after the same meal each day.

See also...