Generic Name: tadalafil (ta DAL a fil)
Brand Names: Adcirca, Cialis

What is Adcirca?

Adcirca (tadalafil) relaxes muscles and increases blood flow to particular areas of the body.

Adcirca is used to treat pulmonary arterial hypertension and improve exercise capacity in men and women.

Adcirca may also be used for purposes not listed in this medication guide.

Important information

You should not use Adcirca if you are allergic to tadalafil.

Do not take Cialis brand of tadalafil while also taking Adcirca, unless your doctor tells you to.

Do not take Adcirca if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking tadalafil with a nitrate medicine can cause a sudden and serious decrease in blood pressure.

Slideshow: Flashback: FDA Drug Approvals 2013

Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis.

Stop using Adcirca and get emergency medical help if you have sudden vision loss.

Before taking this medicine

You should not take Adcirca if you are allergic to tadalafil.

Do not take Adcirca if you are also using a nitrate drug for chest pain or heart problems. This includes nitroglycerin, isosorbide dinitrate, and isosorbide mononitrate. Nitrates are also found in some recreational drugs such as amyl nitrate or nitrite ("poppers"). Taking Adcirca with a nitrate medicine can cause a sudden and serious decrease in blood pressure.

To make sure Adcirca is safe for you, tell your doctor if you have any of these other conditions:

  • heart disease or heart rhythm problems, coronary artery disease;

  • a recent heart attack (within the past 90 days);

  • a recent history (in the past 6 months) of a stroke, or congestive heart failure;

  • angina (chest pain), high or low blood pressure;

  • liver or kidney disease (or if you are on dialysis);

  • a blood cell disorder such as sickle cell anemia, multiple myeloma, or leukemia;

  • a bleeding disorder such as hemophilia;

  • a stomach ulcer;

  • retinitis pigmentosa (an inherited condition of the eye);

  • a physical deformity of the penis (such as Peyronie's disease); or

  • if you have been told you should not have sexual intercourse for health reasons.

Adcirca can decrease blood flow to the optic nerve of the eye, causing sudden vision loss. This has occurred in a small number of people taking Adcirca, most of whom also had heart disease, diabetes, high blood pressure, high cholesterol, or certain pre-existing eye problems, and in those who smoke or are over 50 years old. Stop using Adcirca and get emergency medical help if you have sudden vision loss.

FDA pregnancy category B. Adcirca is not expected to harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant during treatment with this medicine.

See also: Pregnancy and breastfeeding warnings (in more detail)

It is not known whether tadalafil passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take Adcirca?

  • Take Adcirca exactly as your healthcare provider tells you.
  • Adcirca is usually taken only once per day. Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended. Take the tablets at the same time every day. You should take both tablets at the same time, one after the other, every day. Do not split your dose.
  • Adcirca can be taken with or without food.
  • Do not change your dose or stop taking this medicine without speaking to your healthcare provider.
  • If you take too much Adcirca, call your healthcare provider or go to an emergency department right away.

Do not take Cialis for erectile dysfunction if you are taking Adcirca for pulmonary arterial hypertension.

Store at room temperature away from moisture and heat.

What happens if I miss a dose?

If you take Adcirca every day and you miss a dose, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid?

Grapefruit and grapefruit juice may interact with tadalafil and lead to unwanted side effects. Avoid the use of grapefruit products while taking this medicine.

Drinking alcohol can increase certain side effects of Adcirca.

Avoid using any other medicines to treat impotence, such as alprostadil or yohimbine, without first talking to your doctor.

Adcirca side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Adcirca: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Contact your doctor or seek emergency medical attention if your erection is painful or lasts longer than 4 hours. A prolonged erection (priapism) can damage the penis.

Stop using Adcirca and call your doctor at once if you have:

  • vision changes or sudden vision loss;

  • ringing in your ears, or sudden hearing loss;

  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

  • irregular heartbeat;

  • swelling in your hands, ankles, or feet;

  • shortness of breath;

  • seizure (convulsions); or

  • a light-headed feeling, like you might pass out.

Common Adcirca side effects may include:

  • headache;

  • redness or warmth in your face, neck, or chest;

  • cold symptoms such as stuffy nose, sinus pain, sore throat, cough;

  • upset stomach; or

  • muscle pain, back pain, pain in your arms or legs.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

Adcirca dosing information

Usual Adult Dose for Pulmonary Hypertension:

40 mg orally once daily, with or without food. Dividing the dose (40 mg) over the course of the day is not recommended.

What other drugs will affect Adcirca?

Tell your doctor about all medicines you use, and those you start or stop using during your treatment with Adcirca, especially:

  • bosentan;

  • imatinib;

  • nefazodone;

  • St. John's wort;

  • an antibiotic--clarithromycin, erythromycin, telithromycin;

  • antifungal medication--itraconazole, ketoconazole, posaconazole, voriconazole;

  • heart or blood pressure medication--amlodipine nicardipine, quinidine;

  • hepatitis C medications--boceprevir, telaprevir;

  • HIV/AIDS medication--atazanavir, delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir;

  • seizure medication--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone; or

  • tuberculosis medication--isoniazid, rifabutin, rifampin, rifapentine.

This list is not complete. Other drugs may interact with tadalafil, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

Where can I get more information?

  • Your pharmacist can provide more information about Adcirca.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Adcirca only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 10.01. Revision Date: 2013-05-24, 1:44:18 PM.

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