Proglycem Disease Interactions
There are 5 disease interactions with Proglycem (diazoxide).
Diazoxide (applies to Proglycem) arrhythmias
Moderate Potential Hazard, High plausibility.
The use of diazoxide is associated with compensatory tachycardia. Therapy with diazoxide should be administered cautiously in patients with tachycardia.
References
- (2022) "Product Information. Hyperstat (diazoxide)." Apothecon Inc
Diazoxide (applies to Proglycem) congestive heart failure
Moderate Potential Hazard, High plausibility. Applicable conditions: Fluid Retention
Diazoxide may lead to significant fluid retention, which may precipitate congestive heart failure in patients with impaired cardiac reserve. The fluid retention will respond to conventional therapy with diuretics. Therapy with diazoxide should be administered cautiously in patients with congestive heart failure.
References
- (2022) "Product Information. Hyperstat (diazoxide)." Apothecon Inc
Diazoxide (applies to Proglycem) gout
Moderate Potential Hazard, Moderate plausibility.
Diazoxide can increase serum uric acid levels due to decreased excretion. This should be kept in mind, particularly in patients with hyperuricemia or a history of gout.
References
- (2022) "Product Information. Hyperstat (diazoxide)." Apothecon Inc
Diazoxide (applies to Proglycem) pulmonary hypertension
Moderate Potential Hazard, Moderate plausibility.
There have been postmarketing reports of pulmonary hypertension in infants and neonates treated with diazoxide. The cases were reversible upon discontinuation of the drug. Patients should be carefully monitored, especially those with risk factors for pulmonary hypertension, or respiratory distress. Diazoxide should be discontinued if pulmonary hypertension is suspected.
References
- (2022) "Product Information. Hyperstat (diazoxide)." Apothecon Inc
Diazoxide (applies to Proglycem) renal impairment
Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Renal Dysfunction
The plasma half-life of diazoxide is prolonged in patients with impaired renal function. A reduced dosage should be considered. Serum electrolyte levels should also be evaluated for such patients. Caution and monitoring is advised.
References
- (2022) "Product Information. Hyperstat (diazoxide)." Apothecon Inc
Proglycem drug interactions
There are 231 drug interactions with Proglycem (diazoxide).
Proglycem alcohol/food interactions
There is 1 alcohol/food interaction with Proglycem (diazoxide).
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Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.