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Proglycem Side Effects

Generic Name: diazoxide

Note: This page contains side effects data for the generic drug diazoxide. It is possible that some of the dosage forms included below may not apply to the brand name Proglycem.

For the Consumer

Applies to diazoxide: oral capsule, oral suspension

As well as its needed effects, diazoxide (the active ingredient contained in Proglycem) may cause unwanted side effects that require medical attention.

Stop taking diazoxide and get emergency help immediately if any of the following effects occur:

  • Chest pain caused by exercise or activity
  • confusion
  • numbness of the hands
  • shortness of breath (unexplained)

Severity: Moderate

If any of the following side effects occur while taking diazoxide, check with your doctor or nurse as soon as possible:

More common:
  • Decreased urination
  • swelling of feet or lower legs
  • weight gain (rapid)
Less common:
  • Fast heartbeat
  • Fever
  • skin rash
  • stiffness of arms or legs
  • trembling and shaking of hands and fingers
  • unusual bleeding or bruising

Severity: Minor

Some diazoxide side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

Less common:
  • Changes in ability to taste
  • constipation
  • increased hair growth on forehead, back, arms, and legs
  • loss of appetite
  • nausea and vomiting
  • stomach pain

This medicine may cause a temporary increase in hair growth in some people when it is used for a long time. After treatment with diazoxide has ended, normal hair growth should return.

For Healthcare Professionals

Applies to diazoxide: compounding powder, injectable solution, oral capsule, oral suspension


The most common reactions reported following diazoxide (the active ingredient contained in Proglycem) administration include hypotension (7%), nausea and vomiting (4%), dizziness and weakness (2%).[Ref]


Cardiovascular effects including sodium and water retention following repeated injections, hypotension, shock, myocardial ischemia, myocardial and cerebral infarction, angina, atrial and ventricular arrhythmias, marked electrocardiographic changes, optic nerve infarction, supraventricular tachycardia and palpitation, bradycardia, and chest discomfort have been reported.[Ref]

Angina with myocardial and cerebral infarction have been associated with the use of a 300 mg intravenous dose of diazoxide.

One case of optic nerve infarction was reported following a single 300 mg bolus dose of diazoxide, as a result of a sudden reduction in diastolic pressure.

Results from one prospective trial conducted in patients with severe hypertension and coronary artery disease showed a 50% incidence of ischemic changes in the electrocardiogram following single 300 mg bolus injections of diazoxide.[Ref]

Nervous system

Nervous system affects reported following diazoxide (the active ingredient contained in Proglycem) administration include cerebral ischemia, convulsions, paralysis, confusion, numbness of the hands, orthostatic hypotension, sweating, flushing, generalized or localized sensations of warmth, headache, dizziness, lightheadedness, sleepiness, lethargy, somnolence, drowsiness, euphoria, tinnitus, momentary loss of hearing, weakness and anxiety.[Ref]


Gastrointestinal side effects have been rarely reported and include acute pancreatitis, nausea, vomiting, abdominal discomfort, anorexia, alteration in taste, parotid swelling, salivation, dry mouth, lacrimation, ileus, constipation and diarrhea.[Ref]


Metabolic effects including hyperglycemia have been reported in diabetic and nondiabetic patients, especially after repeated injections. Transient retention of nitrogenous wastes has also been reported.[Ref]


Respiratory effects including dyspnea, cough and choking sensation have been reported.[Ref]


Hypersensitivity reactions characterized by rash, leukopenia, fever and papilledema induced by plasma volume expansion secondary to the administration of diazoxide (the active ingredient contained in Proglycem) have been reported.[Ref]


Other effects including warmth or pain along the injected vein, cellulitis and/or phlebitis at the injection site of extravasation, back pain, increased nocturia, malaise, blurred vision, hirsutism, and decreased libido have been reported.[Ref]


1. "Product Information. Hyperstat I.V. (diazoxide)." Schering Corp, Kenilworth, NJ.

It is possible that some side effects of Proglycem may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.