Proglycem Side Effects

Please note - some side effects for Proglycem may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA at http://www.fda.gov/medwatch/ or 1-800-FDA-1088 (1-800-332-1088).

Side Effects of Proglycem - for the Consumer

Proglycem Suspension

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Proglycem Suspension:

Diarrhea; excessive hair growth; headache; loss of appetite; nausea; weakness.

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); excessive drowsiness; excessive hunger or thirst; fast or irregular heartbeat; frequent urination; fruity breath; sudden weight gain; sweating; swelling of the feet or ankles.

Side Effects by Body System

General

The most common reactions reported following diazoxide administration include hypotension (7%), nausea and vomiting (4%), dizziness and weakness (2%).

Cardiovascular

Cardiovascular effects including sodium and water retention following repeated injections, hypotension, shock, myocardial ischemia, myocardial and cerebral infarction, angina, atrial and ventricular arrhythmias, marked electrocardiographic changes, optic nerve infarction, supraventricular tachycardia and palpitation, bradycardia, and chest discomfort have been reported.

Angina with myocardial and cerebral infarction have been associated with the use of a 300 mg intravenous dose of diazoxide.

One case of optic nerve infarction was reported following a single 300 mg bolus dose of diazoxide, as a result of a sudden reduction in diastolic pressure.

Results from one prospective trial conducted in patients with severe hypertension and coronary artery disease showed a 50% incidence of ischemic changes in the electrocardiogram following single 300 mg bolus injections of diazoxide.

Nervous system

Nervous system affects reported following diazoxide administration include cerebral ischemia, convulsions, paralysis, confusion, numbness of the hands, orthostatic hypotension, sweating, flushing, generalized or localized sensations of warmth, headache, dizziness, lightheadedness, sleepiness, lethargy, somnolence, drowsiness, euphoria, tinnitus, momentary loss of hearing, weakness and anxiety.

Gastrointestinal

Gastrointestinal side effects have been rarely reported and include acute pancreatitis, nausea, vomiting, abdominal discomfort, anorexia, alteration in taste, parotid swelling, salivation, dry mouth, lacrimation, ileus, constipation and diarrhea.

Metabolic

Metabolic effects including hyperglycemia have been reported in diabetic and nondiabetic patients, especially after repeated injections. Transient retention of nitrogenous wastes has also been reported.

Respiratory

Respiratory effects including dyspnea, cough and choking sensation have been reported.

Hypersensitivity

Hypersensitivity reactions characterized by rash, leukopenia, fever and papilledema induced by plasma volume expansion secondary to the administration of diazoxide have been reported.

Other

Other effects including warmth or pain along the injected vein, cellulitis and/or phlebitis at the injection site of extravasation, back pain, increased nocturia, malaise, blurred vision, hirsutism, and decreased libido have been reported.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This information does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug of drug combination is safe, effective, or appropriate for any given patient. Drugs.com does not assume any responsibility for any aspect of healthcare administered with the aid of information provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.