Comparing Methotrexate vs Tacrolimus
Methotrexate | Tacrolimus |
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Methotrexate | Tacrolimus |
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Prescription only
Methotrexate may be considered for the treatment of psoriasis or rheumatoid arthritis if other treatments have failed. It may also be used in certain cancers. Side effects can be severe and... View more |
Prescription only
Prescribed for Organ Transplant - Rejection Prophylaxis, Nephrotic Syndrome, Organ Transplant - Rejection Reversal, Graft-versus-host disease, Crohn's Disease. tacrolimus may also be used for... View more |
Related suggestions Graft-versus-host disease
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More about Methotrexate | More about Tacrolimus | ||||||||||||||||
Ratings & Reviews | |||||||||||||||||
Methotrexate has an average rating of 6.6 out of 10 from a total of 330 ratings on Drugs.com. 54% of reviewers reported a positive effect, while 23% reported a negative effect. |
Tacrolimus has an average rating of 8.1 out of 10 from a total of 47 ratings on Drugs.com. 76% of reviewers reported a positive effect, while 10% reported a negative effect. |
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Drug Class | |||||||||||||||||
Side Effects | |||||||||||||||||
See also: methotrexate side effects in more detail. |
See also: tacrolimus side effects in more detail. |
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Generic Availability | |||||||||||||||||
Lower cost generic |
Lower cost generic |
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Pricing and Coupons * Prices are without insurance | |||||||||||||||||
View all methotrexate prices |
View all tacrolimus prices |
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Dosage Form(s) Available | |||||||||||||||||
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Brand Names | |||||||||||||||||
Jylamvo, Methotrexate LPF Sodium, Otrexup, Rasuvo, Trexall, Xatmep | Astagraf XL, Envarsus XR, Prograf | ||||||||||||||||
Half Life The half-life of a drug is the time taken for the plasma concentration of a drug to reduce to half its original value. | |||||||||||||||||
15 hours |
21.2 hours |
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CSA Schedule ** View glossary of terms | |||||||||||||||||
Not a controlled drug
Is not subject to the Controlled Substances Act. |
Not a controlled drug
Is not subject to the Controlled Substances Act. |
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Pregnancy Category | |||||||||||||||||
Category X
Not for use in pregnancy
See the full pregnancy warnings document. |
Category C
Risk cannot be ruled out
See the full pregnancy warnings document. |
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Drug Interactions | |||||||||||||||||
A total of 695 drugs are known to interact with methotrexate:
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A total of 835 drugs are known to interact with tacrolimus:
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Alcohol/Food/Lifestyle Interactions | |||||||||||||||||
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Disease Interactions | |||||||||||||||||
First Approval Date | |||||||||||||||||
December 07, 1953 |
April 08, 1994 |
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WADA Class View World Anti-Doping Agency classifications. | |||||||||||||||||
N/A |
N/A |
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More Information | |||||||||||||||||
Patient resources | |||||||||||||||||
Professional Resources | |||||||||||||||||
Related Treatment Guide | |||||||||||||||||
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** The Controlled Substances Act (CSA) schedule information displayed applies to substances regulated under federal law. There may be variations in CSA schedules between individual states.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.