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Thioguanine

Generic Name: thioguanine (THIGH-oh-GWAHN-een)
Brand Name: Tabloid

Thioguanine is used for:

Treating certain types of cancer (eg, acute nonlymphocytic leukemias). It may also be used for other conditions as determined by your doctor.

Thioguanine is an antineoplastic. It works by blocking cell protein production.

Do NOT use thioguanine if:

  • you are allergic to any ingredient in thioguanine
  • your cancer has previously not responded to thioguanine or to mercaptopurine

Contact your doctor or health care provider right away if any of these apply to you.

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Before using thioguanine:

Some medical conditions may interact with thioguanine. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have bone marrow depression, decreased blood platelets, decreased white blood cell count, or thiopurine methyltransferase deficiency
  • if you have an infection, chickenpox, a weakened immune system, or kidney or liver problems
  • if you are receiving radiation therapy or chemotherapy

Some MEDICINES MAY INTERACT with thioguanine. However, no specific interactions with thioguanine are known at this time.

This may not be a complete list of all interactions that may occur. Ask your health care provider if thioguanine may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use thioguanine:

Use thioguanine as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Thioguanine may be taken with or without food.
  • If you miss a dose of thioguanine, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use thioguanine.

Important safety information:

  • If nausea, vomiting, or loss of appetite occurs, ask your doctor or pharmacist for ways to lessen these effects.
  • Thioguanine may lower your body's ability to fight infection. Prevent infection by avoiding contact with people with colds or other infections. Notify your doctor of any signs of infection, including fever, sore throat, rashes, or chills.
  • Thioguanine may reduce the number of clot-forming cells (platelets) in your blood. To prevent bleeding, avoid situations in which bruising or injury may occur. Report any unusual bleeding, bruising, blood in stools, or dark, tarry stools to your doctor.
  • Avoid vaccination with live virus vaccines (eg, measles, mumps, oral polio) while you are taking thioguanine.
  • LAB TESTS, including complete blood cell counts, platelet levels, or liver function tests, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use thioguanine with caution in the ELDERLY because they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: Thioguanine has been shown to cause harm to the fetus. Avoid becoming pregnant while you are taking thioguanine. If you think that you may be pregnant, discuss with your doctor the benefits and risks of using thioguanine during pregnancy. It is unknown if thioguanine is excreted in breast milk. Do not breast-feed while taking thioguanine.

Possible side effects of thioguanine:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Loss of appetite; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); cough or sore throat; dark urine; fever or chills; infection; joint pain; pale stools; severe or prolonged nausea or vomiting; stomach pain or bloating; sudden weight gain; swelling of the mouth; unusual bruising or bleeding; unusual paleness; unusual tiredness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include excessive sweating; general body discomfort; nausea; severe dizziness; vomiting; weakness.

Proper storage of thioguanine:

Store thioguanine at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep thioguanine out of the reach of children and away from pets.

General information:

  • If you have any questions about thioguanine, please talk with your doctor, pharmacist, or other health care provider.
  • Thioguanine is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take thioguanine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about thioguanine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to thioguanine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using thioguanine.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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