Pancrelipase capsules

Pronunciation

Generic Name: pancrelipase (PAN-kree-LYE-pase)
Brand Name: Examples include Creon and Zenpep

Pancrelipase capsules is used for:

Improving food digestion in patients who cannot digest food properly because they have a pancreas problem (exocrine pancreatic insufficiency) caused by cystic fibrosis or certain other conditions.

Pancrelipase capsules is a digestive enzyme combination. It works by helping the body to digest protein, starch, and fat.

Do NOT use pancrelipase capsules if:

  • you are allergic to any ingredient in pancrelipase capsules

Contact your doctor or health care provider right away if any of these apply to you.

Slideshow: 2014 Update: First Time Brand-to-Generic Switches

Before using pancrelipase capsules:

Some medical conditions may interact with pancrelipase capsules. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances (including pork proteins)
  • if you have gout or high uric acid levels
  • if you have a history of kidney problems, high blood sugar levels, or diabetes
  • if you have a history of pancreas problems or stomach or bowel problems (eg, blockage, scarring or thickening, short bowel syndrome, Crohn disease), or if you have had bowel surgery
  • if you have trouble swallowing capsules

Some MEDICINES MAY INTERACT with pancrelipase capsules. However, no specific interactions with pancrelipase capsules are known at this time.

Ask your health care provider if pancrelipase capsules may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use pancrelipase capsules:

Use pancrelipase capsules as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Pancrelipase capsules comes with an extra patient information sheet called a Medication Guide. Read it carefully. Read it again each time you get pancrelipase capsules refilled.
  • Take pancrelipase capsules by mouth with each meal or snack as directed by your doctor.
  • Swallow pancrelipase capsules whole with enough liquid to swallow it completely. Do not break, crush, chew, or hold pancrelipase capsules in your mouth before swallowing. Doing so may increase the risk of mouth irritation from pancrelipase capsules. Follow with a glass of water or juice. Contact your doctor if you experience mouth irritation while taking pancrelipase capsules.
  • If the patient is an infant (up to 12 months old), open the capsule and sprinkle the contents into the infant's mouth or over a small amount of applesauce at room temperature. Do NOT mix pancrelipase capsules directly in breast milk or formula. If sprinkled onto applesauce, give the mixture to the infant right away. After giving pancrelipase capsules, follow it with breast milk or formula. Be sure that none of the medicine is crushed, chewed, or left in the mouth.
  • If the patient is an adult or child older than 12 months old who cannot swallow the capsule whole, open it and sprinkle the contents over a small amount of acidic soft food (such as applesauce) at room temperature. Mix the medicine with the food and swallow the entire mixture right away, followed by a glass of water or juice. Be sure that none of the medicine is crushed, chewed, or left in the mouth. Check with your doctor if you are unsure which foods you may mix with pancrelipase capsules.
  • If you miss a dose of pancrelipase capsules, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once or take a dose without a snack or a meal.

Ask your health care provider any questions you may have about how to use pancrelipase capsules.

Important safety information:

  • Do NOT take more than the recommended dose without checking with your doctor.
  • Do not switch between pancrelipase capsules and another pancreatic enzyme medicine without first checking with your doctor.
  • Diabetes patients - Pancrelipase capsules may affect your blood sugar. Check your blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Pancrelipase capsules may increase the risk of developing a rare, serious condition called fibrosing colonopathy. When this occurs, it is usually with high doses over a long period of time. It has been most commonly reported in children with cystic fibrosis. Contact your doctor right away if you experience unusual or severe nausea, vomiting, or stomach pain; stomach bloating; or severe or persistent loose stools, constipation, or diarrhea.
  • Pancrelipase capsules comes from pork (pig) pancreas tissue. There is an extremely rare risk of developing a viral disease from this product. No cases of viral disease from pork pancreas products have been identified.
  • Caution is advised when using pancrelipase capsules in CHILDREN; they may be more sensitive to its effects, especially fibrosing colonopathy.
  • PREGNANCY and BREAST-FEEDING: It is not known if pancrelipase capsules can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using pancrelipase capsules while you are pregnant. It is not known if pancrelipase capsules is found in breast milk. If you are or will be breast-feeding while you use pancrelipase capsules, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of pancrelipase capsules:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; decreased appetite; dizziness; gas; headache; irritability; mild diarrhea; sore throat or cough; stomach pain; vomiting; weight loss.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); mouth irritation; painful, swollen joints; severe or persistent loose stools, diarrhea, or constipation; severe or unusual nausea, vomiting, or stomach pain; stomach bloating.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of pancrelipase capsules:

Store pancrelipase capsules at room temperature up to 77 degrees F (25 degrees C). Brief storage at temperatures between 59 and 104 degrees F (15 and 40 degrees C) is permitted for up to 30 days. Keep the bottle tightly closed. Store in the original container away from heat, moisture, and light. Do not store in the bathroom. Keep pancrelipase capsules out of the reach of children and away from pets.

General information:

  • If you have any questions about pancrelipase capsules, please talk with your doctor, pharmacist, or other health care provider.
  • Pancrelipase capsules is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take pancrelipase capsules or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about pancrelipase capsules. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to pancrelipase capsules. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using pancrelipase capsules.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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