Generic Name: pancrelipase (pan kre LYE pace)
Brand Names: Creon, Pancrecarb, Pertzye, Ultrase, Viokase, Zenpep

What is Creon?

Creon (pancrelipase) is a combination of three enzymes (proteins): lipase, protease, and amylase. These enzymes are normally produced by the pancreas and are important in the digestion of fats, proteins, and sugars.

Creon is used to replace these enzymes when the body does not have enough of its own. Certain medical conditions can cause this lack of enzymes, including cystic fibrosis, chronic inflammation of the pancreas, or blockage of the pancreatic ducts.

Creon may also be used following surgical removal of the pancreas.

Creon may also be used for purposes not listed in this medication guide.

Important information

You should not take Creon if you are allergic to pork proteins, or if you have a sudden onset of pancreatitis or worsening of a long-term problem with your pancreas.

Slideshow: 2014 Update - First Time Brand-to-Generic Switches

It is important to use Creon regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Do not hold the capsule contents in your mouth. The medication may irritate the inside of your mouth.

Do not inhale the powder from a Creon capsule, or allow it to touch your skin. It may cause irritation, especially to your nose and lungs.

Before taking this medicine

You should not take Creon if you are allergic to pork proteins, or if you have a sudden onset of pancreatitis or worsening of a long-term problem with your pancreas.

To make sure you can safely take Creon, tell your doctor if you have any of these other conditions:

  • kidney disease;

  • gout; or

  • a history of blockage in your intestines.

FDA pregnancy category C. It is not known whether Creon will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

See also: Pregnancy and breastfeeding warnings (in more detail)

It is not known whether pancrelipase passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

How should I take Creon?

Take Creon exactly as prescribed by your doctor. Do not take it in larger amounts or for longer than recommended. Follow the directions on your prescription label.

It is important to use Creon regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

Creon is usually taken with meals. Follow your doctor's instructions.

Do not hold the capsule contents in your mouth. The medication may irritate the inside of your mouth.

You may open the capsule and sprinkle the medicine into a spoonful of pudding or applesauce to make swallowing easier. Swallow this mixture right away without chewing. Do not save the mixture for later use. Discard the empty capsule.

Do not inhale the powder from a Creon capsule, or allow it to touch your skin. It may cause irritation, especially to your nose and lungs.

Store Creon at room temperature away from moisture and heat. After opening the bottle, keep it closed tightly between uses to protect from moisture.

If the medication is exposed to temperatures between 78 and 104 degrees F, throw it away after 30 days. Do not use any Creon that has been exposed to temperatures above 104 degrees F.

What happens if I miss a dose?

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid?

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Creon side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Creon: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have severe or unusual stomach pain. This could be a symptom of a rare but serious bowel disorder.

Common Creon side effects may include:

  • nausea or vomiting;

  • mild stomach pain or upset;

  • diarrhea or constipation;

  • bloating or gas;

  • greasy stools;

  • rectal irritation;

  • headache, dizziness;

  • cough; or

  • weight loss.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Creon?

Other drugs may interact with Creon, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Where can I get more information?

  • Your pharmacist can provide more information about Creon.
  • Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Creon only for the indication prescribed.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 6.05. Revision Date: 2013-11-05, 9:13:10 AM.

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