Methazolamide

Generic Name: methazolamide (meth-a-ZOLE-a-mide)
Brand Name: Generics only. No brands available.

Methazolamide is used for:

Treating certain types of glaucoma. It may also be used for other conditions as determined by your doctor.

Methazolamide is a carbonic anhydrase inhibitor. It reduces fluid pressure in the eyeball by decreasing fluid formation in the eyeball.

Do NOT use methazolamide if:

  • you are allergic to any ingredient in methazolamide
  • you have adrenal gland problems, low blood levels of potassium or sodium, kidney problems, liver problems (eg, cirrhosis), or high blood levels of chloride or other electrolyte problems

Contact your doctor or health care provider right away if any of these apply to you.

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Before using methazolamide:

Some medical conditions may interact with methazolamide. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have kidney stones, a lung disease, glaucoma (eg, chronic non-congestive angle-closure glaucoma), diabetes, or difficulty breathing
  • if you have had a severe allergic reaction (eg, a severe rash, hives, breathing difficulties, or dizziness) to any other sulfonamide medicine such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide

Some MEDICINES MAY INTERACT with methazolamide. Tell your health care provider if you are taking any of the following medicines:

  • Salicylates (eg, aspirin) because the risk of toxic side effects of methazolamide may be increased
  • Other carbonic anhydrase inhibitors (eg, acetazolamide), cyclosporine, quinidine, phenytoin, amphetamine, or sodium bicarbonate because the actions and side effects of these medicines may be increased
  • Primidone, lithium, or methenamine because the effectiveness of these medicines may be decreased

This may not be a complete list of all interactions that may occur. Ask your health care provider if methazolamide may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use methazolamide:

Use methazolamide as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Methazolamide may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • Drink plenty of water or fluids while taking methazolamide.
  • When you first start taking methazolamide, it may cause an increase in urine or in frequency of urination. To prevent this from affecting sleep, try not to take methazolamide later than 6 pm.
  • If a dose is missed, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use methazolamide.

Important safety information:

  • Methazolamide may cause drowsiness or temporary vision changes. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to methazolamide. Using methazolamide alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Methazolamide may cause increased sensitivity to the sun. Avoid exposure to the sun, sunlamps, or tanning booths until you know how you react to methazolamide. Use a sunscreen or protective clothing if you must be outside for a prolonged period.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using methazolamide.
  • Methazolamide may interfere with certain lab tests. Make sure your doctor and laboratory personnel know you are taking methazolamide.
  • Diabetes patients - Methazolamide may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
  • LAB TESTS, including blood electrolyte levels, complete blood cell count, or platelet levels, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use methazolamide with caution in the ELDERLY because they may be more sensitive to its effects.
  • Use methazolamide with extreme caution in CHILDREN. Safety and effectiveness have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: If you become pregnant, discuss with your doctor the benefits and risks of using methazolamide during pregnancy. It is unknown if methazolamide is excreted in breast milk. Do not breast-feed while taking methazolamide.

Possible side effects of methazolamide:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Blurred vision; changes in taste; constipation; diarrhea; drowsiness; frequent urination; loss of appetite; nausea; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blood in urine; changes in hearing; convulsions; dark, bloody stools; dark urine; fast breathing; fever; lack of energy; lower back pain; red, swollen, or blistered skin; ringing in the ears; sore throat; tingling of the arms or legs; unusual bleeding or bruising; vision changes; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include abnormal skin sensations (eg, tingling, tickling, itching, burning); buzzing, ringing, or whistling in the ears; drowsiness; loss of appetite; loss of coordination; nausea; tremors; unsteady movements; vomiting.

Proper storage of methazolamide:

Store methazolamide at room temperature, between 59 and 86 degrees F (15 and 30 degrees C), in a tightly closed container. Store away from heat, moisture, and light. Do not store in the bathroom. Keep methazolamide out of the reach of children and away from pets.

General information:

  • If you have any questions about methazolamide, please talk with your doctor, pharmacist, or other health care provider.
  • Methazolamide is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take methazolamide or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about methazolamide. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to methazolamide. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using methazolamide.

Issue Date: November 5, 2014
Database Edition 14.4.1.002
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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