Methazolamide Side Effects

Not all side effects for methazolamide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

For the Consumer

Applies to methazolamide: oral tablets

Side effects include:

Paresthesia, hearing dysfunction or tinnitus, fatigue, malaise, anorexia, altered taste, nausea, vomiting, diarrhea, polyuria, drowsiness, confusion.

For Healthcare Professionals

Applies to methazolamide: compounding powder, oral tablet

Nervous system

Nervous system side effects have included paresthesias (most often a tingling in the extremities), hearing dysfunction, tinnitus, taste alteration, drowsiness, and confusion. Flaccid paralysis and convulsions have also been reported.[Ref]

Gastrointestinal

Gastrointestinal side effects have included loss of appetite, nausea, vomiting, and diarrhea.[Ref]

Genitourinary

Genitourinary side effects have included polyuria, hematuria, and glycosuria. Crystalluria and renal calculi have been reported rarely.[Ref]

Hypersensitivity

Hypersensitivity reactions have included rare reports of toxic epidermal necrolysis, Stevens-Johnson syndrome, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias. Photosensitivity has been reported occasionally.[Ref]

Dermatologic

Dermatologic side effects have included urticaria.[Ref]

Metabolic

Metabolic side effects have included metabolic acidosis and electrolyte disturbances.[Ref]

General

General side effects have included fatigue and malaise.[Ref]

Ocular

Ocular side effects have included transient myopia. This can usually be resolved with a reduction in dose or discontinuation of therapy.[Ref]

Hepatic

Hepatic side effects have included hepatic insufficiency.[Ref]

References

1. "Product Information. Neptazane (methazolamide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.

2. Fraunfelder FT, Meyer SM, Bagby GC Jr, Dreis MW "Hematologic reactions to carbonic anhydrase inhibitors." Am J Ophthalmol 100 (1985): 79-81

3. Gandham SB, Spaeth GL, Di Leonardo M, Costa VP "Methazolamide-induced skin eruptions." Arch Ophthalmol 111 (1993): 370-2

4. Moroi-Fetters SE, Metz EN, Chambers RB, Davidorf FH "Aplastic anemia with platelet autoantibodies in a patient after taking methazolamide." Am J Ophthalmol 110 (1990): 570-1

5. Shirato S, Kagaya F, Suzuki Y, Joukou S "Stevens-Johnson syndrome induced by methazolamide treatment." Arch Ophthalmol 115 (1997): 550-3

6. Cotter JB "Methazolamide-induced Stevens-Johnson syndrome: a warning!" Arch Ophthalmol 116 (1998): 117

7. Coudon WL, Block AJ "Acute respiratory failure precipitated by a carbonic anhydrase inhibitor." Chest 69 (1976): 112-3

8. Krivoy N, Ben-Arieh Y, Carter A, Alroy G "Methazolamide-induced hepatitis and pure RBC aplasia." Arch Intern Med 141 (1981): 1229-30

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