Methazolamide Side Effects
Not all side effects for methazolamide may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.
For the Consumer
Applies to methazolamide: oral tablets
Side effects include:
Paresthesia, hearing dysfunction or tinnitus, fatigue, malaise, anorexia, altered taste, nausea, vomiting, diarrhea, polyuria, drowsiness, confusion.
For Healthcare Professionals
Applies to methazolamide: compounding powder, oral tablet
Nervous system side effects have included paresthesias (most often a tingling in the extremities), hearing dysfunction, tinnitus, taste alteration, drowsiness, and confusion. Flaccid paralysis and convulsions have also been reported.[Ref]
Gastrointestinal side effects have included loss of appetite, nausea, vomiting, and diarrhea.[Ref]
Genitourinary side effects have included polyuria, hematuria, and glycosuria. Crystalluria and renal calculi have been reported rarely.[Ref]
Hypersensitivity reactions have included rare reports of toxic epidermal necrolysis, Stevens-Johnson syndrome, fulminant hepatic necrosis, agranulocytosis, aplastic anemia, and other blood dyscrasias. Photosensitivity has been reported occasionally.[Ref]
Dermatologic side effects have included urticaria.[Ref]
Metabolic side effects have included metabolic acidosis and electrolyte disturbances.[Ref]
General side effects have included fatigue and malaise.[Ref]
Ocular side effects have included transient myopia. This can usually be resolved with a reduction in dose or discontinuation of therapy.[Ref]
Hepatic side effects have included hepatic insufficiency.[Ref]
1. "Product Information. Neptazane (methazolamide)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
2. Fraunfelder FT, Meyer SM, Bagby GC Jr, Dreis MW "Hematologic reactions to carbonic anhydrase inhibitors." Am J Ophthalmol 100 (1985): 79-81
3. Cotter JB "Methazolamide-induced Stevens-Johnson syndrome: a warning!" Arch Ophthalmol 116 (1998): 117
4. Gandham SB, Spaeth GL, Di Leonardo M, Costa VP "Methazolamide-induced skin eruptions." Arch Ophthalmol 111 (1993): 370-2
5. Moroi-Fetters SE, Metz EN, Chambers RB, Davidorf FH "Aplastic anemia with platelet autoantibodies in a patient after taking methazolamide." Am J Ophthalmol 110 (1990): 570-1
6. Shirato S, Kagaya F, Suzuki Y, Joukou S "Stevens-Johnson syndrome induced by methazolamide treatment." Arch Ophthalmol 115 (1997): 550-3
7. Coudon WL, Block AJ "Acute respiratory failure precipitated by a carbonic anhydrase inhibitor." Chest 69 (1976): 112-3
8. Krivoy N, Ben-Arieh Y, Carter A, Alroy G "Methazolamide-induced hepatitis and pure RBC aplasia." Arch Intern Med 141 (1981): 1229-30
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