Generic Name: estradiol (ES-tra-DYE-ol)
Brand Name: Estrasorb
Estradiol emulsion should not be used to prevent heart disease, heart attacks, strokes, or dementia. Estrogens with or without progestins have been shown to increase the risk of heart disease (including heart attack), stroke, dementia, serious blood clots (eg, in the lungs or legs), cancer of the uterus, and breast cancer in some women. Tell your doctor right away if you have unusual vaginal bleeding while you use estradiol emulsion. Talk with your doctor if you have questions about the benefits and risks of using estradiol emulsion.
Estradiol emulsion should be used for the shortest possible time at the lowest effective dose to minimize the risk of these side effects. Talk with your doctor regularly about your need to use estradiol emulsion.
Estradiol emulsion is used for:
Treating certain conditions caused by menopause (eg, hot flashes; vaginal itching, burning, or dryness).
Estradiol emulsion is an estrogen hormone used to provide the female hormone when the body no longer produces enough.
Do NOT use estradiol emulsion if:
- you are allergic to any ingredient in estradiol emulsion
- you are pregnant or suspect you may be pregnant
- you have abnormal vaginal bleeding of unknown cause
- you have known, suspected, or a history of breast cancer
- you have known or suspected cancers that are estrogen-dependent
- you have blood clots (eg, in the legs or lungs) or a history of blood clots
- you have ever had a heart attack or stroke
- you have liver problems or blood clotting problems (eg, protein C, protein S, or antithrombin deficiency)
Contact your doctor or health care provider right away if any of these apply to you.
Before using estradiol emulsion:
Some medical conditions may interact with estradiol emulsion. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are planning to become pregnant
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have had yellowing of the eyes or skin during pregnancy or with past estrogen use
- if you have asthma, cancer, certain blood disorder (porphyria), depression, diabetes, epilepsy (seizures), eye or vision problems, fluid retention or swelling (edema), gallbladder disease, heart disease or other heart problems, high blood pressure, high cholesterol or triglyceride levels, high or low calcium levels in the blood, kidney problems, a certain type of liver growth (hemangioma), migraine headaches, pancreatitis, parathyroid gland problems, or thyroid problems
- if you have a history of swelling of the face or tongue (angioedema), an abnormal mammogram or breast lumps, endometriosis, ovarian cancer, or a family history of breast cancer
- if you or a family member have a history of blood clots (eg, in the legs or lungs) or lupus, or have been very overweight
- if you smoke or use tobacco products, you will be having surgery, or you will be on bedrest
- if you have had your uterus removed (hysterectomy)
Some MEDICINES MAY INTERACT with estradiol emulsion. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Clarithromycin, erythromycin, itraconazole, ketoconazole, or ritonavir because they may increase the risk of estradiol emulsion's side effects
- Carbamazepine, phenobarbital, rifampin, or St. John's wort because they may decrease estradiol emulsion's effectiveness
This may not be a complete list of all interactions that may occur. Ask your health care provider if estradiol emulsion may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use estradiol emulsion:
Use estradiol emulsion as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with estradiol emulsion. Talk to your pharmacist if you have questions about this information.
- Estradiol emulsion is for external use only. Do not get it in your eyes or mouth or vagina. If you get it in any of these areas, rinse at once with cool water.
- If you are switching from oral estrogen to estradiol emulsion, talk with your doctor. Follow what you have been told closely.
- Wash your hands with soap and water both before and after using estradiol emulsion.
- Put estradiol emulsion on clean, dry skin of the thighs and calves as your doctor has told you. Do not put estradiol emulsion on the face or breasts.
- Allow the medicine to dry completely before covering with clothing to avoid transfer to other people.
- Grapefruit and grapefruit juice may increase the risk of estradiol emulsion's side effects. Talk to your doctor before including grapefruit or grapefruit juice in your diet while you are taking estradiol emulsion.
- If you miss a dose of estradiol emulsion, put it on as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not put on 2 doses at once.
Ask your health care provider any questions you may have about how to use estradiol emulsion.
Important safety information:
- Tell your doctor or dentist that you take estradiol emulsion before you receive any medical or dental care, emergency care, or surgery.
- Estradiol emulsion may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker and you may need to avoid prolonged sun exposure and sunlamps. Consult your doctor regarding the use of sunscreens and protective clothing.
- Do NOT apply sunscreen at the same time you put estradiol emulsion on. Sunscreen may affect how estradiol emulsion works and cause too much medicine to get into the body.
- If you wear contact lenses and you develop problems with them, contact your doctor.
- If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor beforehand. You may need to stop taking estradiol emulsion at least 4 to 6 weeks beforehand as directed by your doctor.
- Nonprescription therapy to help prevent bone loss includes a weight-bearing exercise plan, as well as adequate daily calcium and vitamin D intake. Consult your doctor or pharmacist for more details.
- Diabetes patients - Estradiol emulsion may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- Estradiol emulsion may interfere with certain lab tests. Be sure your doctor and lab personnel know you are using estradiol emulsion.
- Have your blood pressure checked as you have been told by your doctor.
- Be sure to have regular breast exams and gynecology check-ups. Your doctor will tell you how often to have these. You will also need to do breast self-exams as your doctor has told you. Discuss any questions or concerns with your doctor.
- Lab tests may be performed while you use estradiol emulsion. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Use estradiol emulsion with caution in the ELDERLY; they may be more sensitive to its effects.
- Estradiol emulsion should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Do not use estradiol emulsion if you are pregnant. Avoid becoming pregnant while you are taking it. If you think you may be pregnant, contact your doctor right away. Estradiol emulsion may be found in breast milk. If you are or will be breast-feeding while you use estradiol emulsion, check with your doctor. Discuss any possible risks to your baby.
Possible side effects of estradiol emulsion:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Breast pain or tenderness; hair loss; headache; nausea or vomiting; spotting or breakthrough bleeding; stomach cramps or bloating.
Severe allergic reactions (rash; hives; itching; difficulty breathing or swallowing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); back pain; breast discharge or lump in the breast; chest, jaw, or arm pain; confusion; coughing up blood; fainting; fever; memory problems; mental or mood changes; migraine; one-sided weakness; nipple discharge; painful or difficult urination; persistent or severe breast pain or tenderness; persistent or severe headache, nausea, or vomiting; severe stomach pain; shortness of breath; speech changes; swelling, warmth, numbness, change of color, or pain in a leg or arm; swelling of the hands, legs, or feet; symptoms of liver problems (eg, dark urine, pale stools, persistent loss of appetite, right-sided stomach pain, unusual tiredness, yellowing of the skin or eyes); unusual vaginal bleeding, discharge, itching, or odor; vision changes (eg, double vision, loss of vision).
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of estradiol emulsion:
Store estradiol emulsion at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Store in original packaging until just before use. Store away from heat, moisture, and light. Do not store in the bathroom. Keep estradiol emulsion out of the reach of children and away from pets.
- If you have any questions about estradiol emulsion, please talk with your doctor, pharmacist, or other health care provider.
- Estradiol emulsion is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take estradiol emulsion or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about estradiol emulsion. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to estradiol emulsion. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your health care provider for complete information about the risks and benefits of using estradiol emulsion.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.