Estrasorb

Generic Name: estradiol topical (for use on skin) (ess tra DYE ol TOP ik al)
Brand Names: Divigel, Elestrin, Estrasorb, Estrogel, Evamist

What is Estrasorb?

Estrasorb contains an estrogen hormone called estradiol, a female sex hormone that regulates many processes in the body.

Estrasorb is used to treat certain symptoms of menopause such as hot flashes, and vaginal dryness, burning, and irritation.

Estrasorb may also be used for purposes not listed in this medication guide.

Important information

You should not use Estrasorb if you have any of the following conditions: a history of heart attack, stroke, or blood clot (especially in your lung or your lower body), a bleeding or blood-clotting disorder, liver disease, abnormal vaginal bleeding, history of an allergic reaction to estradiol topical, or a hormone-related cancer such as breast or uterine cancer.

Estrasorb can harm an unborn baby or cause birth defects. Do not use if you are pregnant. Do not use Estrasorb if you are breast-feeding a baby. Topical estradiol is absorbed through the skin and can cause premature puberty in a child who comes into contact with this medicine or with skin where Estrasorb was applied. Call your doctor if a child who has close contact with you develops swollen nipples or enlarged breasts. Children should avoid coming into contact with skin areas where you have applied Estrasorb. If contact does occur, wash with soap and water right away. Cover treated areas with clothing to protect others from coming into contact with the skin where you applied Estrasorb emulsion.

Slideshow: Flashback: FDA Drug Approvals 2013

Estrogens will not prevent heart disease, heart attack, stroke, breast cancer, or dementia, and may actually increase your risk of developing these conditions. Estrogens may also increase your risk of uterine or ovarian cancer.

Talk with your doctor about your individual risks before using Estrasorb long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

Before using Estrasorb

Talk with your doctor about your individual risks before using Estrasorb long-term. Your doctor should check your progress on a regular basis (every 3 to 6 months) to determine whether you should continue this treatment.

You should not use Estrasorb if you have:

  • a history of heart attack, stroke, or blood clot (especially in your lung or your lower body);

  • liver disease;

  • a bleeding or blood-clotting disorder;

  • unusual vaginal bleeding that has not been checked by a doctor;

  • any type of breast, uterine, or hormone-dependent cancer; or

  • if you have ever had an allergic reaction to estradiol topical.

To make sure you can safely use Estrasorb, tell your doctor if you have any of these other conditions:

  • high blood pressure, angina, or heart disease;

  • high cholesterol or triglycerides;

  • kidney disease;

  • asthma;

  • hereditary angioedema;

  • epilepsy or other seizure disorder;

  • migraines;

  • hereditary angioedema;

  • diabetes;

  • a thyroid disorder;

  • depression;

  • porphyria;

  • lupus;

  • gallbladder disease; or

  • low levels of calcium in your blood.

Estrogens will not prevent heart disease, heart attack, stroke, breast cancer, or dementia, and may actually increase your risk of developing these conditions. Estrogens may also increase your risk of uterine or ovarian cancer.

FDA pregnancy category X. Estrasorb can cause birth defects. Do not use Estrasorb if you are pregnant. Tell your doctor right away if you become pregnant during treatment. Use an effective form of birth control while you are using this medication. Estradiol can pass into breast milk and may harm a nursing baby. Estrasorb may also slow breast milk production. Do not use if you are breast-feeding a baby.

See also: Pregnancy and breastfeeding warnings (in more detail)

Estradiol increases your risk of developing endometrial hyperplasia, a condition that may lead to cancer of the uterus. Taking progestins while using estradiol may lower this risk. If your uterus has not been removed, your doctor may prescribe a progestin for you to take while you are using Estrasorb.

How should I use Estrasorb?

Use Estrasorb exactly as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.

Estrasorb comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

Apply Estrasorb only to clean, dry, unbroken skin. Do not apply to skin that is red or irritated. Never apply Estrasorb to the breasts.

To use Estrasorb topical emulsion:

  • Apply Estrasorb while you are sitting comfortably. You will use two foil pouches each time you apply this medication, unless your doctor has told you otherwise.

  • Cut or tear open the foil pouch and place the pouch on top of your left thigh, with the open end of the pouch pointing toward your knee.

  • Hold the pouch with one hand and use the fingers of your other hand to gently push all of the medicine out of the pouch and onto your thigh.

  • Spend at least 3 minutes rubbing the Estrasorb emulsion into your entire left thigh and calf. Rub any excess medicine onto your buttocks.

  • Cut or tear open the second pouch and apply the Estrasorb emulsion to your right leg using the same method described above.

Wash your hands with soap and water after applying the emulsion. Avoid allowing other people to get this medicine on their skin. If this happens, wash the area thoroughly with soap and water. Children should avoid coming into contact with skin areas where you have applied Estrasorb. If contact does occur, wash with soap and water right away. Cover treated areas with clothing to protect others from coming into contact with the skin where you apply this medicine.

Have regular physical exams and self-examine your breasts for lumps on a monthly basis while using Estrasorb.

Store Estrasorb at room temperature away from moisture and heat.

What happens if I miss a dose?

If you are less than 12 hours late in using your medicine, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, vomiting, stomach pain, breast tenderness, drowsiness, and vaginal bleeding.

What should I avoid?

Do not apply sunscreen to your skin at the same time you apply Estrasorb. Avoid getting this medication in your eyes, and rinse thoroughly with water if this does happen.

Grapefruit and grapefruit juice may interact with estradiol and lead to potentially dangerous effects. Discuss the use of grapefruit products with your doctor.

Estrasorb side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Estrasorb: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Estrasorb and call your doctor at once if you have a serious side effect such as:

  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;

  • sudden numbness or weakness, headache, confusion, or problems with vision, speech, or balance;

  • pain, swelling, warmth, or redness in one or both legs;

  • abnormal vaginal bleeding;

  • pain, swelling, or tenderness in your stomach;

  • jaundice (yellowing of the skin or eyes); or

  • a lump in your breast.

Topical estradiol is absorbed through the skin and can cause premature puberty in a child who comes into contact with this medicine or with skin where the medicine was applied. Call your doctor if a child who has close contact with you develops swollen nipples or enlarged breasts.

Less serious Estrasorb side effects may include:

  • nausea, vomiting, loss of appetite;

  • swollen breasts;

  • acne or skin color changes;

  • vaginal pain, dryness, or discomfort, decreased sex drive, or difficulty having an orgasm;

  • swelling, weight gain;

  • migraine headaches, dizziness, depression; or

  • break-through bleeding, vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Estrasorb?

Tell your doctor about all other medications you use, especially:

  • St. John's wort;

  • a blood thinner such as warfarin (Coumadin, Jantoven);

  • ritonavir (Norvir, Kaletra);

  • carbamazepine (Carbatrol, Equetro, Tegretol) or phenobarbital (Luminal, Solfoton);

  • an antibiotic such as clarithromycin (Biaxin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), or rifampin (Rifadin, Rifater, Rifamate, Rimactane)

  • an antifungal medication such as ketoconazole (Extina, Ketozole, Nizoral, Xolegal) or itraconazole (Sporanox).

This list is not complete and other drugs may interact with Estrasorb. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about Estrasorb.
  • Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.

Copyright 1996-2014 Cerner Multum, Inc. Version: 7.01. Revision Date: 2012-06-13, 1:50:54 PM.

Hide
(web4)