Generic Name: dexrazoxane (DEX-ra-ZOX-ane)
Brand Name: Zinecard
Dexrazoxane is used for:
Reducing the risk and severity of heart problems associated with the chemotherapy medicine doxorubicin in certain women being treated for metastatic breast cancer.
Dexrazoxane is a cardioprotective agent. Exactly how dexrazoxane works is not known, but it is thought to work by interfering with harmful chemicals inside of cells that are thought to be partially responsible for heart problems caused by anthracycline (eg, doxorubicin) use.
Do NOT use dexrazoxane if:
- you are allergic to any ingredient in dexrazoxane
- one of your other chemotherapy treatments is not an anthracycline (eg, doxorubicin)
- you have taken or will be taking palifermin within 24 hours before or after using dexrazoxane
Contact your doctor or health care provider right away if any of these apply to you.
Before using dexrazoxane:
Some medical conditions may interact with dexrazoxane. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have bone marrow problems (eg, low blood platelet levels, low red blood cell levels, low white blood cell levels), or kidney or liver problems
Some MEDICINES MAY INTERACT with dexrazoxane. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Palifermin because if mouth or tongue sores develop, they may be more severe or last longer
This may not be a complete list of all interactions that may occur. Ask your health care provider if dexrazoxane may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use dexrazoxane:
Use dexrazoxane as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Dexrazoxane is usually given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
- Do not use dexrazoxane if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- If dexrazoxane comes into contact with the skin, wash it off right away with soap and water.
- If you miss a dose of dexrazoxane, contact your doctor right away.
Ask your health care provider any questions you may have about how to use dexrazoxane.
Important safety information:
- Chemotherapy medicines may reduce the number of clot-forming cells (platelets) in your blood. Dexrazoxane may add to this effect. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
- Chemotherapy medicines may lower the ability of your body to fight infection. Dexrazoxane may add to this effect. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
- The use of dexrazoxane along with certain other chemotherapy medicines may increase the risk of developing a second cancer. Discuss any questions or concerns with your doctor.
- Do not receive a live vaccine (eg, measles, mumps) while you are taking dexrazoxane. Talk with your doctor before you receive any vaccine.
- Lab tests, including heart function and complete blood cell counts, may be performed while you use dexrazoxane. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Dexrazoxane is not approved for use in CHILDREN. Children may be at increased risk of developing a second cancer.
- PREGNANCY and BREAST-FEEDING: Dexrazoxane may cause harm to the fetus. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using dexrazoxane while you are pregnant. It is not known if dexrazoxane is found in breast milk. Do not breast-feed while taking dexrazoxane.
Possible side effects of dexrazoxane:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Diarrhea; hair loss; loss of appetite; mild pain at the injection site; nausea; swelling or soreness of the mouth or tongue; tiredness; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); burning, numbness, or tingling; pain, redness, or swelling at the injection site; symptoms of infection (eg, fever, chills, persistent sore throat); unusual bruising or bleeding; unusual tiredness or weakness.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of dexrazoxane:
Dexrazoxane is handled and stored by a health care provider. Keep dexrazoxane out of the reach of children and away from pets.
- If you have any questions about dexrazoxane, please talk with your doctor, pharmacist, or other health care provider.
- Dexrazoxane is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take dexrazoxane or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about dexrazoxane. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to dexrazoxane. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using dexrazoxane.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More dexrazoxane resources
- dexrazoxane Intravenous Advanced Consumer (Micromedex) - Includes Dosage Information
- Dexrazoxane Prescribing Information (FDA)
- Dexrazoxane Professional Patient Advice (Wolters Kluwer)
- Dexrazoxane Hydrochloride Monograph (AHFS DI)
- Totect Consumer Overview
- Totect Prescribing Information (FDA)
- Zinecard Prescribing Information (FDA)