Advanced Breast Cancer: Learn about treatment options.

Dexrazoxane

Generic Name: dexrazoxane (DEX-ra-ZOX-ane)
Brand Name: Examples include Totect and Zinecard

Dexrazoxane is used for:

Reducing the risk and severity of heart problems associated with the chemotherapy medicine doxorubicin in certain women being treated for metastatic breast cancer. It is also used to treat tissue damage caused by certain cancer medicines that leak from the vein into the skin around the injection site.

Dexrazoxane is a cytoprotective and cardioprotective agent. Exactly how dexrazoxane works is not known.

Do NOT use dexrazoxane if:

  • you are allergic to any ingredient in dexrazoxane
  • one of your other chemotherapy treatments is not an anthracycline (eg, doxorubicin)

Contact your doctor or health care provider right away if any of these apply to you.

Before using dexrazoxane:

Some medical conditions may interact with dexrazoxane. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have bone marrow problems (eg, low blood platelet levels, low red blood cell levels, low white blood cell levels), or kidney or liver problems

Some MEDICINES MAY INTERACT with dexrazoxane. Tell your health care provider if you are taking any other medicines.

Ask your health care provider if dexrazoxane may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use dexrazoxane:

Use dexrazoxane as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • An extra patient leaflet may be available with dexrazoxane. Talk to your pharmacist if you have questions about this information.
  • Dexrazoxane is usually given as an injection at your doctor's office, hospital, or clinic. Contact your health care provider if you have any questions.
  • Do not use dexrazoxane if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • If dexrazoxane comes into contact with the skin, wash it off right away with soap and water.
  • If you miss a dose of dexrazoxane, call your doctor to find out what to do.

Ask your health care provider any questions you may have about how to use dexrazoxane.

Important safety information:

  • Chemotherapy medicines may reduce the number of clot-forming cells (platelets) in your blood. Dexrazoxane may add to this effect. Avoid activities that may cause bruising or injury. Tell your doctor if you have unusual bruising or bleeding. Tell your doctor if you have dark, tarry, or bloody stools.
  • Chemotherapy medicines may lower the ability of your body to fight infection. Dexrazoxane may add to this effect. Avoid contact with people who have colds or infections. Tell your doctor if you notice signs of infection like fever, sore throat, rash, or chills.
  • The use of dexrazoxane along with certain other chemotherapy medicines may increase the risk of developing a second cancer. Discuss any questions or concerns with your doctor.
  • Women who may become pregnant must use an effective form of birth control while taking dexrazoxane. If you have questions about effective birth control, talk with your doctor.
  • Lab tests, including heart function and complete blood cell counts, may be performed while you use dexrazoxane. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Dexrazoxane is not approved for use in CHILDREN. An increased risk of developing a second cancer has been reported in children taking some brands of dexrazoxane along with cancer medicines. Discuss any questions with your doctor.
  • PREGNANCY and BREAST-FEEDING: Dexrazoxane may cause harm to the fetus. Do not become pregnant while you are using it. If you think you may be pregnant, contact your doctor. You will need to discuss the benefits and risks of using dexrazoxane while you are pregnant. It is not known if dexrazoxane is found in breast milk. Do not breast-feed while taking dexrazoxane.

Possible side effects of dexrazoxane:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; hair loss; loss of appetite; mild pain at the injection site; nausea; tiredness; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); burning, numbness, or tingling; pain, redness, or swelling at the injection site; swelling or soreness of the mouth or tongue; symptoms of infection (eg, fever; chills; persistent sore throat or cough; increased, difficult, or painful urination; warm, red, or swollen skin) signs of bleeding (eg, throwing up blood or throw up that looks like coffee grounds; coughing up blood; blood in the urine; black, red, or tarry stools; bleeding from the gums; vaginal bleeding that is not normal; bruises without a reason or that get bigger; or any bleeding that is very bad or that you cannot stop); unusual tiredness or weakness.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of dexrazoxane:

Dexrazoxane is handled and stored by a health care provider. Keep dexrazoxane out of the reach of children and away from pets.

General information:

  • If you have any questions about dexrazoxane, please talk with your doctor, pharmacist, or other health care provider.
  • Dexrazoxane is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take dexrazoxane or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about dexrazoxane. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to dexrazoxane. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using dexrazoxane.

Issue Date: July 2, 2014
Database Edition 14.3.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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