Dexrazoxane Pregnancy and Breastfeeding Warnings
Dexrazoxane Pregnancy Warnings
Dexrazoxane has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of maternotoxicity, embryotoxicity, and teratogenicity. There are no well controlled data in human pregnancy; however, use of dexrazoxane during pregnancy has been associated with fetal harm. Dexrazoxane should only be given during pregnancy when there are no alternatives and the potential benefits outweigh the potential risks to the developing fetus. If dexrazoxane is used during pregnancy or if the patient becomes pregnant during treatment, the patient should be advised of the potential hazard to the developing fetus.
Dexrazoxane Breastfeeding Warnings
There are no data on the excretion of dexrazoxane into human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants exposed to dexrazoxane, one manufacturer of dexrazoxane recommends that "mothers should be advised to discontinue nursing during dexrazoxane therapy" while the other manufacturer recommends that a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.
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