Dexrazoxane Side Effects

Some side effects of dexrazoxane may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

For the Consumer

Applies to dexrazoxane: intravenous powder for injection

Get emergency medical help if you have any of these signs of an allergic reaction while taking dexrazoxane: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor at once if you have any of these serious side effects:

• fever, chills, body aches, flu symptoms, sores in your mouth and throat;

• easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), purple or red pinpoint spots under your skin; or

• bruising, swelling, warmth, redness, oozing, or bleeding of any surgical incision.

Less serious side effects of dexrazoxane may include:

• swelling in your hands or feet;

• hair loss;

• nausea, vomiting, diarrhea, loss of appetite;

• sore throat, trouble swallowing;

• dizziness, tired feeling; or

• pain, swelling, or redness where the medicine was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

For Healthcare Professionals

Applies to dexrazoxane: intravenous powder for injection

Gastrointestinal

Gastrointestinal side effects including nausea (43%), vomiting (19%), diarrhea (11%), abdominal pain (6%), and constipation (6%) have been reported.

General

General side effects including pyrexia (21%), postoperative infection (16%), fatigue (13%), peripheral edema (10%), chest pain, chest discomfort, decreased drug effect, hyperpyrexia, and decreased therapeutic response have been reported.

Local

Local side effects including injection site pain (16%) and injection site phlebitis (6%) have been reported.

Cardiovascular

Cardiovascular side effects including vascular disorders (15%) and cardiac disorders (5%) have been reported.

Dermatologic

Dermatologic side effects including alopecia (14%) have been reported.

Musculoskeletal

Musculoskeletal side effects including "musculoskeletal and connective tissue disorders" (13%) have been reported.

Nervous system

Nervous system side effects including dizziness (11%) and headache (6%) have been reported.

Respiratory

Respiratory side effects including dyspnea (8%), pneumonia (6%), and cough (5%) have been reported.

Psychiatric

Psychiatric side effects including depression (8%), anorexia (5%), and insomnia (5%) have been reported.

Hematologic

Hematologic side effects including anemia (6%), decreased WBC, decreased neutrophils, and decreased platelets have been reported.

Hepatic

Hepatic side effects including increased bilirubin, increased AST, increased ALT, increased alkaline phosphatase, and increased LDH have been reported

Metabolic

Metabolic side effects including increased creatinine, decreased sodium, and increased total calcium have been reported.

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