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Actifed Plus

Generic Name: acetaminophen/pseudoephedrine/triprolidine (a-seet-a-MIN-oh-fen/soo-doe-e-FED-rin/try-PRO-li-deen)
Brand Name: Actifed Plus

Actifed Plus is used for:

Temporarily relieving symptoms of hay fever, allergies, or the common cold, including pain, fever, nasal congestion, runny nose, sneezing, itching of the nose and throat, and itchy/watery eyes. It may also be used for other conditions as determined by your doctor.

Actifed Plus is an analgesic, antihistamine, and decongestant combination. The antihistamine works by blocking the action of histamine, which helps reduce symptoms such as watery eyes and sneezing. The decongestant promotes sinus and nasal drainage, relieving congestion and pressure. The analgesic works in the brain to reduce pain and fever.

Do NOT use Actifed Plus if:

  • you are allergic to any ingredient in Actifed Plus
  • you are taking droxidopa or sodium oxybate (GHB), or you have taken furazolidone or a monoamine oxidase (MAO) inhibitor (eg, phenelzine) within the past 14 days
  • you have severe high blood pressure or severe heart disease (eg, coronary artery disease, ischemic heart disease)

Contact your doctor or health care provider right away if any of these apply to you.

Video: Asthma

How to prevent and treat an asthma attack.

Before using Actifed Plus:

Some medical conditions may interact with Actifed Plus. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have glaucoma or increased pressure in the eyes; high blood pressure; diabetes; heart or blood vessel disease; overactive thyroid; seizures; blockage of the stomach, bowel, or bladder; trouble breathing when you sleep; trouble sleeping; a breathing problem (eg, asthma, emphysema, chronic bronchitis); the blood disease porphyria; or an enlarged prostate or prostate disease; or if you have difficulty urinating
  • if you have a history of liver problems (eg, hepatitis) or severe kidney problems

Some MEDICINES MAY INTERACT with Actifed Plus. Tell your health care provider if you are taking any other medicines, especially if any of the following apply to you:

  • Furazolidone or MAO inhibitors (eg, phenelzine) because side effects such as severe headache, high blood pressure, or high fever may occur
  • Bromocriptine or sodium oxybate (GHB) because the risk of side effects or toxic effects may be increased by Actifed Plus
  • Guanethidine, guanadrel, mecamylamine, methyldopa, or reserpine because their effectiveness may be decreased by Actifed Plus.
  • Droxidopa because side effects such as irregular heartbeat or heart attack may occur
  • Urinary alkalinizers (eg, sodium bicarbonate) because the side effects of Actifed Plus may be increased
  • Anticoagulants (eg, warfarin) or isoniazid because the risk of bleeding or liver problems may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if Actifed Plus may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use Actifed Plus:

Use Actifed Plus as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Actifed Plus may be taken with or without food. If stomach upset occurs, take with food to reduce stomach irritation.
  • If you miss a dose of Actifed Plus and are using it regularly, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use Actifed Plus.

Important safety information:

  • Actifed Plus may cause dizziness or drowsiness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to Actifed Plus. Using Actifed Plus alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Avoid drinking alcohol or taking other medications that cause drowsiness (eg, sedatives, tranquilizers) while taking Actifed Plus. Actifed Plus will add to the effects of alcohol and other depressants. Ask your pharmacist if you have questions about which medicines are depressants.
  • Contact your health care provider if symptoms last for more than 7 days or are accompanied by a fever.
  • Diabetes patients - Actifed Plus may affect your blood sugar. Check blood sugar levels closely and ask your doctor before adjusting the dose of your diabetes medicine.
  • Actifed Plus contains pseudoephedrine and acetaminophen. Before you begin taking any new prescription or nonprescription medicine, including medicine used on the skin, read the ingredients to see if it also contains pseudoephedrine or acetaminophen. If it does, or if you are uncertain if it does, contact your doctor or pharmacist.
  • Do not take diet or appetite control medicines while you are taking Actifed Plus without checking with your doctor.
  • Do not exceed the recommended dose or take Actifed Plus for longer than prescribed without checking with your doctor.
  • If you have trouble sleeping, ask your pharmacist or doctor about the best time of day to take Actifed Plus.
  • Use Actifed Plus with caution in the ELDERLY because they may be more sensitive to its effects.
  • Caution is advised when using Actifed Plus in CHILDREN because they may be more sensitive to its effects, especially excitability.
  • PREGNANCY AND BREAST-FEEDING: If you become pregnant while taking Actifed Plus, discuss with your doctor the benefits and risks of using Actifed Plus during pregnancy. If you are or will be breast-feeding while you are using Actifed Plus, check with your doctor or pharmacist to discuss the risks to your baby.

Possible side effects of Actifed Plus:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Constipation; diarrhea; dizziness; drowsiness; dry mouth, nose, or throat; excitability (especially in children); headache; loss of appetite; nausea; nervousness; restlessness; trouble sleeping; vomiting.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); blurred vision; chest pain; decreased coordination; difficulty urinating; fast or irregular heartbeat; fever; hallucinations; seizure; severe dizziness and drowsiness; severe nervousness, anxiety, or restlessness; stomach pain; tremors; unusual weakness; yellowing of the skin or eyes.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include bluish-colored skin; difficulty breathing; dilated pupils; fast or irregular heartbeat; fever; flushing; hallucinations; mental or mood changes; seizures; severe drowsiness or dizziness; severe excitability; severe nausea or vomiting; sweating; tremors.

Proper storage of Actifed Plus:

Store Actifed Plus at room temperature, between 59 and 77 degrees F (15 and 25 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep Actifed Plus out of the reach of children and away from pets.

General information:

  • If you have any questions about Actifed Plus, please talk with your doctor, pharmacist, or other health care provider.
  • Actifed Plus is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information is a summary only. It does not contain all information about Actifed Plus. If you have questions about the medicine you are taking or would like more information, check with your doctor, pharmacist, or other health care provider.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

More about Actifed Cold and Sinus (acetaminophen / pseudoephedrine / triprolidine)

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